1.Association between Higher Blood Pressure and Risk of Diabetes Mellitus in Middle-Aged and Elderly Chinese Adults
Xue YANG ; Jian CHEN ; An PAN ; Jason H.Y. WU ; Fei ZHAO ; Yue XIE ; Yi WANG ; Yi YE ; Xiong-Fei PAN ; Chun-Xia YANG
Diabetes & Metabolism Journal 2020;44(3):436-445
To examine the prospective association between higher blood pressure (BP) and risk of type 2 diabetes mellitus (T2DM) in middle-aged and elderly Chinese adults. A total of 9,642 middle-aged and elderly Chinese adults (≥45 years old; 47.30% men) without diabetes from the China Health and Retirement Longitudinal Study were included for analyses. Participants were categorized into three groups: normal BP, prehypertension, and hypertension, according to the 2010 Chinese Guidelines for the Management of Hypertension. The incidence of T2DM was determined by self-reported physician diagnosis during two follow-up surveys conducted in 2013 to 2014 and 2015 to 2016. During the 4-year follow-up, 429 participants (4.45%) developed T2DM, including 3.51% of the men and 5.29% of the women. The incidence rates of T2DM were 2.57%, 3.75%, and 6.71% in the normal BP, prehypertension, and hypertension groups, respectively. After adjustment for age, sex, education level, residence, smoking status, alcohol consumption, body mass index, waist circumference, and dyslipidemia, both prehypertension (odds ratio [OR], 1.32; 95% confidence interval [CI], 0.98 to 1.77) and hypertension (OR, 2.02; 95% CI, 1.54 to 2.64) were associated with increased risk of T2DM, compared to those with a normal BP. The ORs associated with T2DM were 1.08 (95% CI, 1.03 to 1.13) for an increase of 10 mm Hg in systolic BP and 1.06 (95% CI, 1.01 to 1.10) for an increase of 5 mm Hg in diastolic BP. Higher BP is a risk factor for T2DM in middle-aged and elderly Chines. It may be a potential target for diabetes prevention.
2.Investigations of clinical characteristics and inflammatory markers of febrile seizures induced by coronavirus infection
Zhao, L. ; Wu, H.Y. ; Xie, D. ; Mo, L.M. ; Yang, F.F. ; Gao, Y. ; Zhao, X.L. ; He, Y.Z.
Tropical Biomedicine 2023;40(No.4):439-443
The study of children who experienced with febrile seizures(FS) as a result of COVID-19 infection to gain
insight into the clinical characteristics and prognosis of neurological damage, with the aim of improving
prevention, diagnosis, and the treatment of neurological complications. This study investigated the
clinical features of 53 children with FS who were admitted to Sanya Women and Children’s Hospital
from December 1, 2022, to January 31, 2023. The results indicated that the duration of convulsion in
the case and control group was 7.90±8.91 and 2.67±1.23 (minutes) respectively. The analysis reveals
that convulsions occurred within 24 hours in 39 cases (95.12%) of the case group, and in 8 cases
(66.7%) of the control group. The difference was statistically significant (P<0.05). Additionally, the case
group presented lower counts of WBC and NEU compared to the control group (p<0.05). The findings
indicate that convulsions manifest at earlier stages of COVID-19 in children and the last longer than
in the control group. It is therefore crucial for healthcare workers to remain attentive to patients with
COVID-19 who report fever within 24 hours, and act promptly to implement preventive measures,
particularly in cases of prolonged fever. It is essential to integrate the clinical manifestation, particularly
convulsions, and the continuous numerical changes of inflammatory factors to assess COVID-19 linked
with febrile seizures. In addition, larger-scale multi-center and systematic research are necessary to
aid clinicians in monitoring neuropathological signals and biological targets, enabling more equitable
diagnosis and treatment plans.
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