1.Inflammatory Bowel Disease-related Colorectal Cancer in the Asia-Pacific Region: Past, Present, and Future.
Wong ZHIQIN ; Shanthi PALANIAPPAN ; Raja Affendi RAJA ALI
Intestinal Research 2014;12(3):194-204
Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and key contributing factors include chronic colonic inflammation and the extent and duration of disease. This increase in risk is more likely to result from chronic inflammation of the colonic mucosa than from any clearly defined genetic predisposition. However, globally, the true magnitude of this risk is debatable, since results from different studies are heterogeneous in terms of geographical and methodological variables. The prevalence of IBD-related CRC in the Asia-Pacific region ranges from 0.3% to 1.8% and a recent study found that the cumulative incidence of IBD-related CRC is comparable to that in Western countries. However, the CRC mortality rate in the Asia-Pacific region is on the rise compared with that in Western countries, and a few Asian countries show particularly rapid upward trends in CRC incidence. Although our understanding of the molecular and clinical basis for IBD-related CRC has improved substantially, our means of prevention, endoscopic surveillance, chemoprevention, and prophylactic surgery remain modest at best. Furthermore, published data on IBD-related CRC in the Asia-Pacific region is lacking, and this review addresses many aspects including epidemiology, natural history, etiopathogenesis, morphology, and biological behaviors of IBD-related CRC and sporadic CRC in the Asia-Pacific region. In this review, we will also discuss the risk factors for CRC in IBD patients, endoscopic technology screening, and surveillance programs and management strategies for IBD-related CRC.
Asian Continental Ancestry Group
;
Chemoprevention
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Colon
;
Colorectal Neoplasms*
;
Epidemiology
;
Genetic Predisposition to Disease
;
Humans
;
Incidence
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Inflammation
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Inflammatory Bowel Diseases
;
Mass Screening
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Mortality
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Mucous Membrane
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Natural History
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Prevalence
;
Risk Factors
2.Optimizing the multidimensional aspects of the patient-physician relationship in the management of inflammatory bowel disease.
Deborah CHEW ; Wong ZHIQIN ; Norhayati IBRAHIM ; Raja Affendi Raja ALI
Intestinal Research 2018;16(4):509-521
The patient-physician relationship has a pivotal impact on the inflammatory bowel disease (IBD) outcomes. However, there are many challenges in the patient-physician relationship; lag time in diagnosis which results in frustration and an anchoring bias against the treating gastroenterologist, the widespread availability of medical information on the internet has resulted in patients having their own ideas of treatment, which may be incongruent from the treating physicians’ goals resulting in patient physician discordance. Because IBD is an incurable disease, the goal of treatment is to sustain remission. To achieve this, patients may have to go through several lines of treatment. The period of receiving stepping up, top down or even accelerated stepping up medications may result in a lot of frustration and anxiety for the patient and may compromise the patient-physician relationship. IBD patients are also prone to psychological distress that further compromises the patient-physician relationship. Despite numerous published data regarding the medical and surgical treatment options available for IBD, there is a lack of data regarding methods to improve the therapeutic patient-physician relationship. In this review article, we aim to encapsulate the challenges faced in the patient-physician relationship and ways to overcome in for an improved outcome in IBD.
Anxiety
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Bias (Epidemiology)
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Communication Barriers
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Diagnosis
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Frustration
;
Humans
;
Inflammatory Bowel Diseases*
;
Internet
3.Colonoscopic Polypectomy Preferences of Asian Endoscopists:Results of a Survey-Based Study
Dong-Hoon YANG ; Bayasgalan LUVSANDAGVA ; Quang Trung TRAN ; Achmad FAUZI ; Panida PIYACHATURAWAT ; Thida SOE ; Zhiqin WONG ; Jeong-Sik BYEON
Gut and Liver 2021;15(3):391-400
Background/Aims:
The clinical practice pattern of polypectomy is not well-investigated in Asian countries. We aimed to survey Asian endoscopists about their preferred polypectomy techniques for given conditions and images of polyps.
Methods:
A survey was performed using questionnaires composed of two parts: a scenariobased questionnaire using scenarios of polyps, which were adopted from the European Society of Gastrointestinal Endoscopy guidelines, and an image-based questionnaire using provided endoscopic images of polyps.
Results:
A total of 154 endoscopists participated in this survey. The most preferred resection techniques for diminutive (≤5 mm), small (6–9 mm), and benign-looking intermediate (10–19 mm) nonpedunculated polyps were cold forceps polypectomy, hot snare polypectomy, and endoscop-ic mucosal resection (EMR), respectively, in both the scenario- and image-based questionnaires. For benign-looking large (≥20 mm) nonpedunculated polyps, EMR and endoscopic submucosal dissection (ESD) were preferred in the scenario- and image-based surveys, respectively. In case of malignant nonpedunculated polyps, EMR and ESD were preferred for intermediate-sized and large lesions, respectively, according to the scenario-based survey. However, ESD was preferred in both intermediate-sized and large malignant nonpedunculated polyps according to the imagebased survey. Trainee endoscopists, endoscopists working in referral centers, and endoscopistsin the colorectal cancer–prevalent countries were independently associated with preference of cold snare polypectomy for removing small polyps.
Conclusions
The polypectomy practice patterns of Asian endoscopists vary, and cold snare polypectomy was not the most preferred resection method for polyps <10 mm in size, in contrast to recent guidelines.
4.Adherence to Surveillance Guidelines after the Removal of Colorectal Polyps: A Multinational, Multicenter, Prospective Survey
Chang Kyo OH ; Satimai ANIWAN ; Panida PIYACHATURAWAT ; Zhiqin WONG ; Thida SOE ; Bayasgalan LUVSANDAGVA ; Quang Trung TRAN ; Achmad FAUZI ; Jeong-Sik BYEON ; Young-Seok CHO
Gut and Liver 2021;15(6):878-886
Background/Aims:
As the number of colonoscopies and polypectomies performed continues to increase in many Asian countries, there is a great demand for surveillance colonoscopy. The aim of this study was to investigate the adherence to postpolypectomy surveillance guidelines among physicians in Asia.
Methods:
A survey study was performed in seven Asian countries. An email invitation with a link to the survey was sent to participants who were asked to complete the questionnaire consisting of eight clinical scenarios.
Results:
Of the 137 doctors invited, 123 (89.8%) provided valid responses. Approximately 50% of the participants adhered to the guidelines regardless of the risk of adenoma, except in the case of tubulovillous adenoma ≥10 mm combined with high-grade dysplasia, in which 35% of the participants adhered to the guidelines. The participants were stratified according to the number of colonoscopies performed: ≥20 colonoscopies per month (high volume group) and <20 colo-noscopies per month (low volume group). Higher adherence to the postpolypectomy surveillance guidelines was evident in the high volume group (60%) than in the low volume group (25%). The reasons for nonadherence included concern of missed polyps (59%), the low cost of colonoscopy (26%), concern of incomplete resection (25%), and concern of medical liability (15%).
Conclusions
A discrepancy between clinical practice and surveillance guidelines among physicians in Asia was found. Physicians in the low volume group frequently did not adhere to the guidelines, suggesting a need for continuing education and appropriate control. Concerns regarding the quality of colonoscopy and complete polypectomy were the main reasons for nonadherence.
5.Colonoscopic Polypectomy Preferences of Asian Endoscopists:Results of a Survey-Based Study
Dong-Hoon YANG ; Bayasgalan LUVSANDAGVA ; Quang Trung TRAN ; Achmad FAUZI ; Panida PIYACHATURAWAT ; Thida SOE ; Zhiqin WONG ; Jeong-Sik BYEON
Gut and Liver 2021;15(3):391-400
Background/Aims:
The clinical practice pattern of polypectomy is not well-investigated in Asian countries. We aimed to survey Asian endoscopists about their preferred polypectomy techniques for given conditions and images of polyps.
Methods:
A survey was performed using questionnaires composed of two parts: a scenariobased questionnaire using scenarios of polyps, which were adopted from the European Society of Gastrointestinal Endoscopy guidelines, and an image-based questionnaire using provided endoscopic images of polyps.
Results:
A total of 154 endoscopists participated in this survey. The most preferred resection techniques for diminutive (≤5 mm), small (6–9 mm), and benign-looking intermediate (10–19 mm) nonpedunculated polyps were cold forceps polypectomy, hot snare polypectomy, and endoscop-ic mucosal resection (EMR), respectively, in both the scenario- and image-based questionnaires. For benign-looking large (≥20 mm) nonpedunculated polyps, EMR and endoscopic submucosal dissection (ESD) were preferred in the scenario- and image-based surveys, respectively. In case of malignant nonpedunculated polyps, EMR and ESD were preferred for intermediate-sized and large lesions, respectively, according to the scenario-based survey. However, ESD was preferred in both intermediate-sized and large malignant nonpedunculated polyps according to the imagebased survey. Trainee endoscopists, endoscopists working in referral centers, and endoscopistsin the colorectal cancer–prevalent countries were independently associated with preference of cold snare polypectomy for removing small polyps.
Conclusions
The polypectomy practice patterns of Asian endoscopists vary, and cold snare polypectomy was not the most preferred resection method for polyps <10 mm in size, in contrast to recent guidelines.
6.Hepatocellular carcinoma: A local registry on risk factors, imaging patterns, treatment strategies and overall survival
Manju Tambe Raja ; Nur Yazmin Yaacob ; Wong Zhiqin ; Chik Ian
The Medical Journal of Malaysia 2021;76(2):151-156
Introduction: Hepatocellular carcinoma (HCC) is among the
common death-causing cancers worldwide. This liver
malignancy is primarily diagnosed using radiological
imaging techniques. Most of the patients in Malaysia present
late and were diagnosed at an intermediate or advanced
stage of Barcelona Clinic of Liver Cancer (BCLC). This
causes a limitation on the treatment options for the patients.
Materials and Methods: We performed a retrospective crosssectional study of HCC cases within a five-year period in our
center with data collected from Hospital Canselor Tunku
Mukhriz (HCTM). This study examines the HCC risk factors,
the pattern of diagnosis, treatment options and overall
survival.
Results: The findings from this study showed that viral
hepatitis was the highest risk factor in which most of the
patients were elderly males who presented with abdominal
distension. In addition, given the high prevalence of
metabolic diseases Malaysia, it is predicted that the number
of non-alcoholic steatohepatosis (NASH)-related HCC cases
might increase. Alpha-fetoprotein (AFP) proved to have no
significant role in the detection of the disease. The number
of patients detected at early BCLC was minimal, resulting in
limited options of treatment. Overall survival of our HCC
patients was poor at 17 months.
Conclusion: We conclude that HCC patients in HCTM mostly
presented at late stage to hospital, hence limiting the
treatment options and resulted in poor survival rate. Disease
awareness should be implemented at primary care level to
detect HCC at its early stage. Subsequently, a
multidisciplinary hospital team is required to manage the
disease at its different stages of presentation.
7.It’s not just a heartburn and reflux disease: a case report of distal oesophageal spasm and review of literature
Khairul Najmi Muhammad Nawawi ; Zhiqin Wong ; Chai Soon Ngiu ; Raja Affendi Raja Ali
The Medical Journal of Malaysia 2019;74(6):540-542
Distal oesophageal spasm is a rare condition that affects the
motility of the oesophagus. It can be diagnosed by highresolution oesophageal manometry and the diagnosis is
supported by other modalities such as barium swallow and
esophagogastroduodenoscopy examinations. Treatment
options include pharmacological therapy, endoscopy and
surgical interventions. We described a case of distal
oesophageal spasm in an elderly patient who presented with
chronic dyspepsia.