Malaria is a parasitic disease that is caused by the Plasmodium
parasite. Worldwide, it remains a significant public health
problem especially in the Africa region where it contributes to
more than 90% of cases and malaria death. However, zoonotic
(simian) Plasmodium knowlesi parasite is a widely prevalent
cause of malaria in the South East Asian countries. It is known
to cause severe human disease due to its 24hour erythrocytic
cycles. Thus far, cases of severe falciparum malaria have been
reported in asplenic patients. Here, we report a case of severe
P.knowlesi malaria in a 51-year-old man who is a postsplenectomy patient.