The Japanese Society of Gastroenterology revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2015. The revised guidelines consist of the following items:bleeding gastric and duodenal ulcers, Helicobacter pylori(Hp)eradication therapy and non-eradication therapy,drug-induced ulcer,non-Hp/ non-nonsteroidal anti-inflammatory drug( NSAID)-induced ulcer,and surgical treatment. This guideline describes the abovementioned content in detail and is a good reference for clinical practice. A full interpretation of this guideline was performed in this paper.

In patients with gastrointestinal bleeding,the elderly patients have the unique features in bleeding incidence,etiologic constitution,clinical manifestations,management and prognosis. The aging of population makes the evaluation and management of gastrointestinal bleeding in elderly a special and increasingly common clinical challenge. This paper reviewed this topic in detail.

A global consensus meeting on Helicobacter pylori(H. pylori)gastritis was held in Kyoto,Japan from January 31st to February 1st ,2014,which was convened to develop consensus on:(1)H. pylori gastritis is an infectious disease,(2)clinical distinction of dyspepsia caused by H. pylori from functional dyspepsia,(3)appropriate diagnostic assessment of gastritis and(4)when,whom and how to treat H. pylori gastritis. All 24 statements for 22 clinical questions achieved a consensus level of > 80% . In this paper,the statements were interpreted in detail.

Gastrointestinal(GI)bleeding is one of the commonly seen clinical problems in departments of emergency and gastroenterology. Acute massive bleeding may be life-threatening,and chronic blood loss can present symptoms of anemia. GI bleeding is the clinical manifestation of some serious diseases,including GI malignancies. Familiar with and mastering the clinical manifestations,classification and principles of management of GI bleeding will help to improve its prevention and treatment.

In order to observe the clinical effect of Tuina therapy for vertigo, 47 cases of the patients with vertigo were treated by massaging Triple Energizer Meridian and Gallbladder Meridian on the head, and the results showed cure in 36 cases, improvement in 11 cases and the total effective rate was 100%.

Having been given Phenformin (DBI) for up to 6 months, 40 cases of NIDDM with normal hepatic and renal functions showed various degrees of hyperlactacidemia. The mean value of hyperlactacidemia increased with ages, but had no relation to the course of disease. Since DBI is liable to cause hyperlactacidemic coma, it is suggested that DBI, if indicated,should be used with great prudence, especially for those senile diabetics with impaired hepatic and renal functions.

The chromosome automatic analysis system may help physicians diagnose cancers and other genetic disorders at an early stage. A computer-assisted system usually includes a series of processing steps,such as image enhancement,chromosome segmentation,feature extraction and chromosome classification. However,developing such an automated system is quite a challenging and difficult task. A number of different algorithms have been applied during the research of these systems,and encouraging results have been achieved. This paper introduced the development of the chromosome automatic analysis systems,and summarized various algorithms used in these systems. Due to limitation of some factors,further research is needed to improve the efficiency and the accuracy of these systems. The limited factors are analyzed in this paper and the development tendency is predicted.

The indication for eradication of Helicobacter pylori( Hp)has been gradually expanded from peptic ulcer to“confirmed Hp infection”. Kyoto global consensus report on Hp gastritis has defined Hp gastritis as an infectious disease, and proposed that eradication therapy should be given to Hp infected individuals unless there are competing considerations. Currently the issue of Hp infection is no longer whether it should be eradicated,but rather how it can be effectively eradicated. With the rise of antibiotic resistance,Hp eradication is much more difficult than beforehand. This series of lectures on how to improve the eradication rate of Hp has been elaborated in detail in following aspects:current status of Hp eradication therapy,how to improve the eradication rate of drug-resistant strains of Hp,and to explore suitable eradication regimens for Chinese patients in reference with international consensus.

“Management of Helicobacter pylori infection — the Maastricht Ⅴ Consensus Conference”held in Florence, Italy,October 8-9th,2015 was convened for developing a new consensus on the management of Helicobacter pylori infection in following aspects:1. Indication/ Associations,2. Diagnosis,3. Treatment,4. Prevention/ Public Health,5. Helicobacter pylori and the Gastric Microbiota. A detailed interpretation of these contents was made in this paper.

Peptic ulcer bleeding is a common emergency. Management of peptic ulcer bleeding needs prompt pre-endoscopy risk stratification,initiation of pharmacotherapy,endoscopic assessment and hemostasis if necessary. This article reviewed the proper management of patients with peptic ulcer bleeding based on the most recent relevant international guidelines and consensus.