Analysis and determination of the content of four active factors of Vitamin E in Malva rotundifolia oilwere carried out by normal and reverse phase HPLC. The retention mechanism on the normal and reversephase columns of the four active factors was studied.

Stroke is a type of neurological disease with high morbidity,disability,and mortality.It has become a global public health problem.At present,the stroke burden in countries around the world has shown an upward trend.This article reviews the extent of population health hazards caused by stroke,as well as the evaluation of economic burden of the disease.

Objective To evaluate the applicability and effectiveness of the model for managing patients with convulsive epilepsy in rural China.Methods The model is under leadership of the government departments and medical institutions at all levels organized primary physicians for treatment and management.People with convulsive epilepsy in 24 rural areas were screened by local physicians and confirmed by neurologists.Patients diagnosed with convulsive epilepsy and agreed with managing were recruited into study.They were managed at primary care level and provided with phenobarbital monotherapy.Efficacy was assessed from the changes in seizure frequencies from baseline.Results There were 408 town hospitals and 979 trained primary care physicians participating in our study.Five thousand and thirty-eight patients were enrolled in 2 years,and 90％ patients with good compliance.Among the people who were treated with phenobarbital monotherapy,3 170 were managed for 12 months,and 2 005 (63.3％) of whom had a 50％ or greater reduction in seizure frequency and 1 246 (39.3％)patients remained seizure free;651 patients were managed for 24 months,and 491 (75.4％) of whom had a 50％ or greater reduction in seizure frequency and 202(31.0％)patients remained seizure free.Three hundred and forty-three (6.8％) patients withdrew from the study,and only 35 (0.7％) patients discontinued treatment because of side effects.Sixty-nine (1.4％) patients were dead and 8 (11.6％) of them were caused by status epilepticus.Conclusion This study confirms that this model is beneficial to patients with epilepsy and is suitable to the rural areas of China.

Global Campaign Against Epilepsy conducted the Demonstration Project to improve epilepsy care in rural China from 2000 to 2004. The project involved 5 provinces and 2,455 patients with convulsive epilepsy using phenobarbital monotherapy. Forty percent of the patients were seizure free in one year and another 30% had their seizures decreased by over half. With the support of the central government, the project has currently been extended to cover 12 provinces with 11,000 patients. The long-term plan is to integrate epilepsy management into the existing primary health delivery system of China.

It has recently been demonstrated that anti-angiogenesis drugs targeting every possible aspect of tumor angiogenesis effectively inhibit the growth, invasion and metastasis of breast cancer with low sideeffects and drug resistance. These types of anti-angiogenesis drugs have become a hotspot in the field of breast cancer research.

As a novel Golgi protein,GOLPH2 expression is associated with maintaining the structural integrity of the Golgi apparatus.As an oncoprotein,GOLPH2 expression is associated with malignant biological behavior of cancer cells.Important roles of GOLPH2 in the tumorigenesis and metastasis make it become a new target for tumor diagnosis and treatment.

Objective To evaluate the effects of prostaglandin E1 (PGE1 ) infused in the pulmonary artery of the ventilated lung on hemodynamics and pulmonary gas exchange during one-lung ventilation (OLV).Methods Experiments were performed on 12 healthy pigs of both sexes (6 males , 6 females) aged 3 months, weighing 14-17 kg. The animals were anesthetized with intramuscular ketamine 15-20 mg?kg-1 , diazepam 1.5-2.0 mg?kg-1 and atropine. The animals were mechanically ventilated after tracheal intubation (FiO2 = 0.7, VT = 12-15 ml?kg-1, RR=15bpm, I:E=l:2). PaCO2 was maintained at 35-45 mm Hg. Swan-Ganz catheter was positioned in the right pulmonary artery via the left femoral vein. The right femoral artery was cannulated for BP monitoring and blood sampling. Anesthesia was maintained with a mixture of ketamine 100 mg and succinylcholine 100 mg in 2% procaine 100 ml infused i.v. at a rate of 2-3 ml?kg-1?h-1. The animals were placed in right lateral position. The left chest was opened and OLV was established by clamping the left main bronchus. During OLV RR was increased from 15 to 20 bpm but the minute ventilation remained unchanged. The animals were randomly divided into 2 groups of six : group A and B. Group A received PGE1 infusion in the right pulmonary artery with an initial dose of 0.01 ?g?kg-1?min-1 which was gradually increased to 0.02, 0.04, 0.06, 0.08 and 0.1 ?g?kg-1?min-1 . Theinfusion of each dose was maintained for 20 min. In group B normal saline was infused instead of PGE1. MAP, HR, CVP, PCWP, CO, PaO2 PvO2 were recorded at each dose and at 20, 40, 60 min after PGE1 infusion was terminated. Qs/Qt, PVR and SVR were calculated.Results MPAP, PVR, SVR, peak inspiratory pressure (PIP) and Qs / Qt significantly increased while CO, Cdyn and PaO2 significantly decreased (P 0.05) and a significant decrease of MPAP and PVR ( P

Objective To find out exposure level and distributional characteristics of risk factors for stroke in sampling population among communities. Methods Target population aged≥40 years were selected from Beijing,Shanghai,Fuzhou and Tangshan by cluster sampling and grouped by area,age and gender. They were investigated face to face with a questionnaire which included general information and common risk factors of stroke. Body height,weight and levels of blood pressures were measured. Exposure rate of risk factors and its distributional characteristics of area and population were described. Results 23 471 individuals were enlisted into data analysis. Exposure rate of hypertension,heart disease,diabetes,family history of stroke,obesity,cigarette smoking and alcohol drinking were 27.73%,14.14%,5.19%,15.95%,11.28%,28.7% and 16.6%,respectively. There were significant differences between areas for all factors (P

Objective To look into the effects of community intervention measures on blood pressure and hypertension control of the population.Methods Two geographic separated urban communities with the population about 50 000 each were selected as either intervention or control communities in Beijing in 1996.In the intervention community,the primary and secondary prevention on high blood pressure were carried out.And the morbidity and mortality of stroke in both intervention and control populations were monitored.A baseline survey and evaluation re-survey were respectively conducted in 1997 and 2000 covering both intervention and control communities with a cluster random sample of about 800 persons each.Results In the baseline survey,there were no difference between intervention and control communities in six of seven variables including systolic blood pressure(SBP),diastolic blood pressure(DBP),prevalence of hypertension,rate of awareness,therapy,control with SBP 140 and DBP

Objective To evaluate effects of pulmonary surfactant (PS) containing ketamine on respiratory failure induced with lung-lavage in rats Methods Twenty Wistar rats were anesthetized with intraperitoneal pentobarbital sodium and were ventilated with the peak inspiratory pressure(PIP) being 1 47 kPa and E:I at 1:1 following intubation through tracheotomy In all rats whole double lung lavage were performed with normal saline (37℃, 40 ml?kg -1 ) 8 10 times after PIP and PEEP were adjusted to 1 96 kPa and 0 49 kPa respectively The rats were randomly divided into A and B groups after PaO 2 decreased to less than 12 kPa In group A (n=10): PS (25mg, 0 5ml) was injected intratracheally to lungs; in group B (n=10): PS (25mg, 0 5ml) containing ketamine 2 5 mg was injected At 120th min after PS injection, PIP and PEEP were gradually adjusted to 1 47 kPa and 0 kpa (ZPEEP), respectively Results PaO 2 in both groups decreased significantly from 59 3 kPa to 10 3 kPa after lung lavage(P0 05 vs pre-lavage) All rats in group B and 4 of 10 rats in group A survived at the end of experiment Conclusions Intratracheal administration with PS containing ketamine not only reverses hypoxemia , but also maintains the respiratory function under low airway pressure without PEEP after respiratory failure induced with lung lavage,