Objective To investigate the relationship between the severity of coronary artery disease and malignant arrhythmia in the acute ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), and guide clinical prevention and treatment .Methods By retrospective analysis method , 418 cases of hospitalized patients with a diagno-sis of STEMI undergoing direct PCI were continuously collected in the Department of Cardiology , the First Affiliated Hospital of China Medical University, from 2008 January to 2010 December.Electrocardiography (ECG) was given after admission.Those patients were divided into two groups according to whether the occurrence of malignant ventricular arrhythmias that was defined as sustained ventricu -lar tachycardia (sVT) or ventricular fibrillation (VF)].In sVT/VF patients, the preoperative and postoperative groups were divided according to sVT/VF time.The degree of coronary artery lesions was calculated in patients with STEMI .The incidence of sVT/VF was counted in each group with Gensini scores <60,≥60 and<120, and ≥120.The relationship between the severity of coronary le-sions and malignant arrhythmia was observed in STEMI undergoing direct PCI patients .Results ⑴In this study , a total of 47 cases ( 11.2%) occurred with sVT/VF in patients;Killip grade >I, fast heart rate , low blood pressure , and low ejection fraction were risk factors of sVT/VF( P <0.05).The occurrence of sVT/VF among the Gensini groups were significant difference (7.1%vs 10.8%vs 20.5%, P =0.012 ) .⑵The occurrence of sVT/VF was 44.8% ( 22 patients ) with direct PCI before operation; the preoperative sVT/VF rate among the Gensini groups had significant difference (2.1%vs 5.9%vs 9.6%, P =0.045).⑶The occurrence of sVT/VF is 53.3%(25 patients) with direct PCI after operation; the postoperative sVT/VF rate among Gensini groups had no significant difference(5.0%vs 4.9%vs 11.0%, P =0.142);⑷Paired with age ( x±2), gender, hypertension, and diabetes 1, Logistic re-gression analysis showed that the heart rate greater than 80 beats /min ( P =0.04 , OR:2.667 , 95%CI:1.043~6.815 ) was an independent risk factor of preoperative sVT/VF, that Gensini score was not an independent risk factor of preoperative malignant ar -rhythmia.Conclusions For STEMI PCI patients, the more serious the degree of coronary artery is , the higher may be preoperative malignant arrhythmia , while the postoperative malignant arrhythmia rate has no significant difference .

Objective:To observe the curative effect of traditional Chinese medicine on non-alcoholic fatty liver patients and CTN(computerized tomographynumber)of liver,than to appraise the role of assessment and diagnosis on non-alcoholic fatty liver for CT.Methods:60 patients with non-alcoholic fatty liver were divided into treatment group and contrast group in average,the patients in treatment group were treated by Xiaozhihugan capsule and Dangfeiliganning capsule,and those in contrast group were treated by Kezhi capsule and Shuifeijibin capsule.Changes of symptom,liver function,blood fat,ultrasonic report and liver CTN were observed.Results:In the treat group,the liver function,blood fat and liver CT value were improved obviously,which had superiority to that of contrast group.CT can diagnose the degree of fatty liver accurately and appraise curative effect,but ultrasonic report has no specific data and is inconvenient to statistics.Conclusions:Treatment group has notable curative effect on non-alcoholic fatty liver;CT is the important index of diagnosis and appraisement of curative effect on non-alcoholic fatty liver.

Objective:To evaluate the effect of milrinone in treating refractory heart failure.Methods:5mg of milrinone in 250ml of 5% Glucose or 0.9% NaCl Solution were given daily by intravenous drip to 56 cases of refractory heart failure for a period of consecutive 7 days.The symptoms and signs were observed before and after the treatment,heart rate,blood pressure and heart function examined by Doppler echocardiography.Results:a.The total effective rate was 85.7%.b.The left ventricular ejection fraction (LVEF) and fraction shortening (FS) were increased significantly (P＜0.01) after treatment.The rate of filling velocity in early diastole (E) over that in late diastole (A) was increased significantly (P＜0.05).Conclusion:Milrinone has good effect for treating refractory heart failure.It improves not only the cardiac systolic function but also the diastolic function.

Objective: To eliminate the noise of the plethysmography wave and obtain plethysmography wave signal without noise. Methods:Using sym4 and combining the improved wavelet threshold wavelet algorithm to remove high frequency white noise of plethysmography wave, and then using spline differential fitting method to remove baseline drift of pulse wave volume. Results:The experimental results show that the high frequency noise and baseline drift of plethysmography wave have been removed effectively processed by the sym4 wavelet and combining with improved threshold of wavelet algorithm and spline difference after fitting. Conclusion:The method can well remove the noise of the plethysmography wave and retains the effective information of plethysmography wave effectively.

OBJECTIVE To probe how to avoid the complication after intravenous infusion for the elders. METHODS The cause of the complication in infusion therapy for the elders with a total of 80 cases in the past three years was analyzed retrospectively. RESULTS Among the complications after intravenous infusion for 80 elders,leakage injury accounted for 47 cases(58.5%), and phlebitis accounted for 21 cases(26.8%),respectively. CONCLUSIONS As the elders′ blood vessel wall is very thin,the intravenous infusion often causes injury,the nurses should pay more attention to operating of intravenous infusion for the elders,observing regularly,and prolonging the time for pressing the pinprick after pulling out the dropper,in order to reduce the coming of injury.

Objective:The research investigated the characters of college students' autonomy and its relation to social adjustment.Methods:650 college students from Xi'an completed The Self-Regulatory Questionnaire and The Chinese College Student Adjustment Scale (CCSAS).Results:① Boys' autonomy level was higher than girls';There were no significant differences of autonomy level in the first three years of college,but the senior year appeared a slight reduction.②There were significant correlations between autonomy and social adjustment.③Students with higher autonomy had significant better social adjustment than lower autonomy students.④ Autonomy had direct effect on social adjustment.Conclusion:There are significant correlations between autonomy and social adjustment.

[Objective]To investigate Y-shaped osteotomy and the internal fixation with geese-head steel plates for treatment of congenital coxa vara.[Method]Lesser subtrochanteric and greater laterotrochanteric osteotomy were performed for 7 cases(9 hips)of congenital coxa vara with the Y-shaped osteotomy line.The distal femoral section met the lateral greater trochanteric section,fixed with geese-head steel plates.[Result]The cases were followed up for 1~5 years(averaged 3.6 years).According to Shi Yingqi's evaluation,4 hips were excellent,4 good and 1 fair.[Conclusion]The Y-shaped osteotomy and internal fixation with geese-head steel plates can improve the abnormal structure of upper femur,increase the real length of the affected limb.Therefore,it is an ideal effective method for treatment of congenital coxa vara.

ObjectiveTo observe the therapeutic effect of early comprehensive rehabilitation and the value of intensity time (I/t) curve examine for peripheral facial paralysis.Methods89 patients with peripheral facial paralysis were treated by early comprehensive rehabilitation program in 1 week and were examined by I/t curve in 10～20 days.ResultsThe rate of the cure and excellent was 93.26%.Normal nerve detected by I/t curve were 62.92% and partial denervation were 37.08%.ConclusionPatients with peripheral facial paralysis who were treated by early comprehensive rehabilitation will have good prognosis. As a kind of examine ways, I/t curve can be used in clinic.

Objective To study the expression and clinical significance of Survivin and PTEN in cervical carcinoma. Methods The expression of Survivin and PTEN in 60 cases of cervical carcinoma, 15 cases of CIN Ⅰ , 15 cases of CIN Ⅱ, 15 cases of CIN Ⅲ and 15 cases of normal cervical tissues were detected by immunohistochemical staining. Results The expression positive rates of Survivin were 86.67 %, 80.00 %,33.33 %, 20.00 % and 0, respectively, and those of PTEN were 21.67 %, 40.00 %, 80.00 %, 86.67 % and 100.00 % in cervical carcinoma, CIN Ⅲ, CIN Ⅱ, CIN Ⅰ and normal cervical tissues, respectively. The expression positive rates of Survivin were increased along with normal cervical epithelium, CIN Ⅰ, CIN Ⅱ,CIN Ⅲ and invasive carcinoma of cervix;while those of PTEN were inverse order.Compared with the expression positive rates of Survivin and PTEN protein in the CIN Ⅱ group, those in the CIN Ⅲ group had significant differences (P <0.01 and P <0.05, respectively). Expressions of Survivin and PTEN were correlated to the size of focus(P <0.05), the depth of tumor and pelvic lymphnode metastasis (P <0.05), but not to clinical staging, pathological types, pathological grading and age(P >0.05). There was a negative correlation between the expression of PTEN and Survivin in cervical carcinoma. Conclusion The expressions of Survivin and PTEN are correlated with invasion and metastasis of cervical carcinoma, and be related to clinical pathotology.Survivin and PTEN may play a important role in the formation, proliferation, differentuation and metastasis of cervical carcinoma. They may be used as markers of early diagnose, efficacy and prognosis evaluation.

Alzheimer′s disease(AD)is a degenerative metabolic disease,whose exact pathological mechanism still remains unknown. Currently,studies have found that patients in AD accompany with insulin signaling pathway impairment and cerebral glu?cose metabolism dysfunction. As insulin signaling pathway and cerebral glucose metabolism homeostasis play a key role in AD ,some researches consider AD as“typeⅢdiabetes”. This review aims to discuss the alteration of cerebral insulin signaling pathway and glu?cose metabolism in AD,as well as their relationship with AD. We will also elaborate the advance in anti-AD drugs based on cerebral insulin signaling pathway.