In order to investigate the influence of recombinant human liver regeneration augmenter (hALR) on serum hyaluronic acid content in the process of experimental liver fibrosis, two kinds of animal models of rat experimental liver fibrosis induced by CCl 4 and albumin were established and different dosages of hALR were given during establishing the model. Serum specimens were obtained in different period of model establishment, and hyaluronic acid content was measured by radioimmunoassay (RIA). Results showed that in both rat models of experimental liver fibrosis, serum hyaluronic acid content in two hALR treatment group was significantly lower than that in different periods of model establishment. Serum concentration of hyaluronic acid in large dose of hALR treatment group was also significantly lower than that in low dose of hALR treatment group. These results indicate that recombinant human liver regeneration augmenter may decrease serum hyaluronic acid content in experimental liver fibrosis.

To investigate the sexual quality of life and its influencing factors in patients with cervical cancer undergoing radiotherapy. Methods Totally 205 patients with cervical cancer who received radiotherapy in Peking Union Medical College Hospital from December 2013 to December 2018 were enrolled in this study.The Female Sexual Function Index(FSFI)scale was used to assess the sexual quality of life of these patients.The demographic data(including age,education level,marital status,family status,and occupation)and clinical data(including tumor stage and treatment method)were collected.Mann-Whitney test and Kruskal-Wallis test were used to analyze the influence of various factors on the sexual quality of life. Results Female sexual dysfunction was common among patients with cervical cancer undergoing radiotherapy.The total FSFI score was 5.5(3.6,16.3),and the scores of subscales were as follows:desire,1.20(0,1.80);sexual arousal,0.90(0,1.80);vaginal lubrication,0.30(0,3.30);orgasm,0(0,2.80);satisfaction,2.40(1.60,3.60);and sexual pain,0(0,2.80).Age(=0.010),duration of radiotherapy(=0.008),marital status(=0.020),family status(=0.010),and occupation(=0.024)were influential factors of sexual quality of life in cervical cancer patients undergoing radiotherapy. Conclusions The sexual quality of life of patients with cervical cancer undergoing radiotherapy is affected by multiple factors.Instructions on treatment,mental status,and post-treatment sexual life should be offered in an individualized way to improve the sexual quality of life of these patients.
Female ; Humans ; Quality of Life ; Sexual Dysfunction, Physiological ; Surveys and Questionnaires ; Uterine Cervical Neoplasms ; radiotherapy