Objective To investigate the relationship between essential hypertension and serum C-reactive protein and plasma lipids.Methods Detecting fasting serum CRP and plasma lipid in each group of hypertensive patients to investigate the relationship between hypertension and fasting serum CRP and plasma lipids.Results CRP,TC,TG,HDL-C and LDL-C level of A,B and C group had significant differences with that of D group(t =4.03, 4.23, 4.61, 3.12, 3.41, 2.76,2.98,2.56,2.64,2.57,3.05,3.68,2.54,3.16,4.28,all P＜0.05).CRP,TC,TG,HDL-C and LDL-C levels between A,B and C group had significant differences(F = 4.68,4.05,3.29,3.59,4.11,all P＜0.05).There was significant correlation between serum CRP level and TC,TG,HDL-C,LDL-C level in 186 hypertension patients(r =0.274,0.356,0.327,0.302,all P＜0.05).Conclusion CRP,TC,TG and LDL-C levels showed significant linear correlation in patients with hypertension.

Objective To assess the clinical value of multi-slice helical CT perfusion on the post-operative follow-up of glioma.Methods CT perfusion image was applied to 32 patients with glioma after operation.Various perfusion parameters,include cerebral blood volume(CBV),permeability surface(PS),relative cerebral blood volume(rCBV)and relative permeability surface(rPS)were measured on recurrent area,nonrecurrent area and normal cerebral area respectively.SPSS 12.0 statistical software was used.Independent t test was used to compare the differences.Results In the recurrent group(16 cases),the value of CBV in creased in 12 cases and was normal in the other 4 cases.The value of PS increased in all the cases of recurrent group.The value of rCBV exceeded 2.6 in 10 cases,among which the biggest value of rCBV was 4.01.The mean value of rCBV was 2.67 and the mean value of rPS was 6.32;In the non-recurrent group(16 cases),the value of CBV was nearly normal in 7 cases,increased in 2 cases and decreased in the remaining 7 cases.The value of PS was nearly normal in 11 case,decreased in 3 cases and increased in the remaining 2 cases.The values of rCBV were all less than 2.6 and the biggest value of rCBV was 2.14.The mean value of rCBV was 0.99 and the mean value of rPS was 1.42.The statistic significance was obtained for all the parameters when compared the recurrent group with the non-recurrent group(P＜0.01)and with the normal cerebral area(P＜0.01).When compared the non-recurrent group with the normal cerebral area,none of the parameters had statistic significance(P＞0.05);The statistic significance was obtained for rCBV and rPS when compared the recurrent group with the non-recurrent group(P＜0.01).Conclusion CT perfusion image is valuable in determining glioma recurrence after operation.

Chemotherapy completion rate can reflect the tolerance and compliance of patients to chemotherapy. Poor tolerance may result in delay or suspension of the comprehensive treatment plan, thus affect the efficacy of cancer treatment. Evaluating methods to improve the completion rate of chemotherapy and reduce the occurrence of delayed chemotherapy has gained increasing attention and is the significant area of study in the field of cancer treatment. Studies have shown that Chinese medicine combined with chemotherapy could improve the quality of life in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC).

Objective To compare the procotol of EGDT +Pt (cv-a ) CO2 with EGDT in fluid resuscitation and management after evaluate fluid responsiveness in shock patients by Vigileo and passive leg raising test.Metheds Prospectively collect patients who meet the criteria between 2013.5.1-2013.1 1.30 in our ICU.Randomly (random number)divided into Vigileo group (first evaluate the fluid responsiveness then give EGDT +Pt (cv-a) CO2 ) and CVP group (give EGDT).Compare the hospital mortality and morbility of MODS,the volume given in the first 6 hours and the first 7 days,consume of blood products , the ICU and hospital stay.Results Collected 46 patients,Vigileo group (21 )and CVP group (25 ). There’s no significant difference between groups at baseline.In the first 6 hours the CVP group had received more fluids (3656.281678.57 vs. 2639.141326.59 ) mL, P =0.03;and more blood products (573.00172.57 vs. 190.4770.82)mL,P=0.04,respictivily.Vigileo group significantly short the ICU stay ,(6.384.34 vs. 12.165.77)d,P=0.04.But there’s no significant difference in hospital motality and the morbility of MODS.The ROC of Age ,the accumulative volume of balance in 7 days,APACHEⅡscore in the first day to predict death is 0.84 (0.68-0.99)、0.82 (0.69-0.95)、0.80 (0.66-0.94),all P>0.05,respectively.By 7 days the accumulative volume of balance 3454.51mL as cutoff to predict death with the sensitivity of 0.67,specificity of 0.84.Conclusions 1.Given EGDT +Pt (cv-a) CO2 after evaluate the fluid responsiveness can reduce fluid and blood products given in the first 6 hours,significantly short the ICU stay,without worsen the tissue flow or increase the morbility of MODS;2.Consecutive positive fluid balance is a risk factor about poor prognosis,and also a sensitive indicator to predict death.

Objective To investigate the independent factors influencing the efficacy of pre-hospital CPR effect. Method The data base with 1376 cases was set up with EpiData software by means of questionnaires and the information was provided by the survivals from cardiopulmonary arrest( CA)saved with cardiopulmonary resuscitation(CPR), and the data were analyzed with SPSS 13.0 software to carry out binary logistic regression. Through single factor analysis, the factors with emerged statistical significance were chosen as variances. Results With regard to the restoration of spontaneous circulation(ROSC), the rescue did by the first witness was the protective factor(PF)( OR = 2.21, P = 0.001, 95.0% CI=1.356-3.602); the male was the risk factor(RF) contrasted with the female( OR = 0. 515, P =0. 006, 95.0%0 CI = 0.320 - 0. 26) ; ages between 20 and 29 years old had higher likelihood of ROSC than group ≥81 years old( OR = 3.241, P = 0.026, 95.0%CI = 1.146 -9.138); the length of CA time before CPR was RF(OR = 0.913, P = 0.000, 95.0%CI = 0.887-0.948);ventricular fibrillation(VF) was PF compared with asystole( OR = 5.092, P = 0.000, 95.0%CI=2.927 -8.861); electric shock was PF(OR = 3.384, P = 0.000, 95.0%CI = 2.033 - 5.635); epinephrine dosage 0 - 4 mg had higher likelihood of ROSC than > 5 nag dosage( OR = 3. 255, P = 0. 001, 95.0% CI = 1. 606 -6.597). In respect of probability about victims at the tittle reached hospital alive, ages of 2- 12 and 13 - 19 years old had higher rations than ≥81 years old( OR = 12.818, P = 0.029, 95.0% CI = 1.299 - 126.508)( OR = 10.505, P = 0.036, 95.0% CI = 1.161-95.058); the length of CA time before CPR was RF(OR =0.862, P = 0.000, 95.0%CI = 0.821-0.906); VF was PF compared with asystole(OR = 7.330, P =0.000, 95.0%CI = 3.962 - 13.560). Conclusions ECG change before CPR, rescue by the first witness,electric shock, the length of CA time before CPR, epinephrine dosage, gender and age were independent influencing factors of pre-hospital CPR for the emergency of ROSC. Age, the length of CA time before CPR and ECG before CPR were influencing factors of pre-hospital CPR for patients at the time transferred to hospital alive.

Recently the maintenance therapy of non-small-cell lung cancer (NSCLC) patients who completed required treatment cycles has caused widespread interests in the medical field. Traditional Chinese medicine may be a useful complement in maintenance treatment of mid-to-late stage NSCLC.

Objective To explore the effects of Xingnaojing injection on plasma MMP-9 and TIMP-1 levels for patients with cerebral hemorrhage. Methods A total of 60 patients with acute cerebral hemorrhage from February 2014 to May 2015 were selected as research subjects and randomly divided into the research group and the control group, with 30 patients in each group. The research group was given Xingnaojing injection on the basis of regular treatment, and the control group was given regular treatment. The plasma MMP-9 and TIMP-1 levels of the two groups of patients were compared, and the correlation between MMP-9 and TIMP-1 levels in the patients and their correlation with cere-bral edema were analyzed. Results On the fifth day of onset of the disease in the two groups of patients, MMP-9 and TIMP-1 levels were significantly increased, and the levels were reduced on the 14th day. On the fifth day and 14th day of onset of the disease in the research group, MMP-9 level was significantly lower than that in the control group, and TIMP-1 level was significantly higher than that in the control group. The differences were statistically significant (P<0.01). In 24 h, the volume of cerebral edema in the two groups was positively correlated to MMP-9 (r=0.682, P=0.761), and was significantly negatively correlated to TIMP-1(r=-0.489, P=-0.619); on the 14th day, the volume of cerebral edema was positively correlated to MMP-9 (r=0.516, P=0.835). Conclusion Xingnaojing is able to significantly reduce the increasing degree of MMP-1 in the patients with cerebral hemorrhage, enhance the increasing degree of TIMP-1, and improve patients' cerebral edema.

Objective The aim of this study was to retrospectively investigate the multi?detector computed tomography ( MDCT ) features of preinvasive lesions and minimally invasive adenocarcinoma (MIA) appearing as ground?glass nodules ( GGNs), and to analyze their significance in differential diagnosis. Methods The pathological data and MDCT images of 111 GGNs in 93 patients were reviewed and analyzed retrospectively, to identify the differentiating CT features between preinvasive lesions and MIA and to evaluate their differentiating accuracy. Results In the 93 patients included in the study, there were 27 cases with preinvasive lesions ( 38 GGNs) and 66 cases with MIA ( 73 GGNs) . No statistically significant difference was observed in terms of the gender, age and number of lesions between the two groups. There were significant differences (P<0.05) in the size of lesion, size of solid portion, content of solid portion, and morphological characteristics of the lesion edge between preinvasive lesions and MIA. ROC curve analysis showed that the optimal cut?off value of lesion size for differentiating preinvasive lesions from MIA was 13. 0 mm ( sensitivity, 83. 0%; specificity, 80. 0%) , and that of solid portion size was 2. 0 mm ( sensitivity, 90. 0%; specificity, 97. 0%) and that of solid proportion was 12. 0% ( sensitivity, 88. 0%;specificity, 97.0%) . The analysis of CT morphological features showed that there were significant differences in the terms of lesion nature (pGGO, mGGO), presence or absence of lobulated sign and spiculated sign ( P<0.05) between preinvasive lesions and MIA, but there were no significant differences in terms of the lesion edge, the presence or absence of vacuole sign, bubble lucency and pleural retraction ( P>0. 05 ) . Conclusions Preinvasive lesions can be accurately distinguished from MIA by the size of lesion, size of solid portion,solid proportion and morphological characteristics of the lesion edge. The size of lesion, size of solid portion, content of solid proportion and morphological characteristics of the lesion edge are of significance in the differential diagnosis of preinvasive lesions and minimally invasive adenocarcinoma of the lung.

Objective The aim of this study was to retrospectively investigate the multi?detector computed tomography ( MDCT ) features of preinvasive lesions and minimally invasive adenocarcinoma (MIA) appearing as ground?glass nodules ( GGNs), and to analyze their significance in differential diagnosis. Methods The pathological data and MDCT images of 111 GGNs in 93 patients were reviewed and analyzed retrospectively, to identify the differentiating CT features between preinvasive lesions and MIA and to evaluate their differentiating accuracy. Results In the 93 patients included in the study, there were 27 cases with preinvasive lesions ( 38 GGNs) and 66 cases with MIA ( 73 GGNs) . No statistically significant difference was observed in terms of the gender, age and number of lesions between the two groups. There were significant differences (P<0.05) in the size of lesion, size of solid portion, content of solid portion, and morphological characteristics of the lesion edge between preinvasive lesions and MIA. ROC curve analysis showed that the optimal cut?off value of lesion size for differentiating preinvasive lesions from MIA was 13. 0 mm ( sensitivity, 83. 0%; specificity, 80. 0%) , and that of solid portion size was 2. 0 mm ( sensitivity, 90. 0%; specificity, 97. 0%) and that of solid proportion was 12. 0% ( sensitivity, 88. 0%;specificity, 97.0%) . The analysis of CT morphological features showed that there were significant differences in the terms of lesion nature (pGGO, mGGO), presence or absence of lobulated sign and spiculated sign ( P<0.05) between preinvasive lesions and MIA, but there were no significant differences in terms of the lesion edge, the presence or absence of vacuole sign, bubble lucency and pleural retraction ( P>0. 05 ) . Conclusions Preinvasive lesions can be accurately distinguished from MIA by the size of lesion, size of solid portion,solid proportion and morphological characteristics of the lesion edge. The size of lesion, size of solid portion, content of solid proportion and morphological characteristics of the lesion edge are of significance in the differential diagnosis of preinvasive lesions and minimally invasive adenocarcinoma of the lung.

OBJECTIVEThe aim of this study was to retrospectively investigate the multi-detector computed tomography (MDCT) features of preinvasive lesions and minimally invasive adenocarcinoma (MIA) appearing as ground-glass nodules (GGNs), and to analyze their significance in differential diagnosis.

METHODSThe pathological data and MDCT images of 111 GGNs in 93 patients were reviewed and analyzed retrospectively, to identify the differentiating CT features between preinvasive lesions and MIA and to evaluate their differentiating accuracy.

RESULTSIn the 93 patients included in the study, there were 27 cases with preinvasive lesions (38 GGNs) and 66 cases with MIA (73 GGNs). No statistically significant difference was observed in terms of the gender, age and number of lesions between the two groups. There were significant differences (P<0.05) in the size of lesion, size of solid portion, content of solid portion, and morphological characteristics of the lesion edge between preinvasive lesions and MIA. ROC curve analysis showed that the optimal cut-off value of lesion size for differentiating preinvasive lesions from MIA was 13.0 mm (sensitivity, 83.0%; specificity, 80.0%), and that of solid portion size was 2.0 mm (sensitivity, 90.0%; specificity, 97.0%) and that of solid proportion was 12.0% (sensitivity, 88.0%; specificity, 97.0%). The analysis of CT morphological features showed that there were significant differences in the terms of lesion nature (pGGO, mGGO), presence or absence of lobulated sign and spiculated sign (P<0.05) between preinvasive lesions and MIA, but there were no significant differences in terms of the lesion edge, the presence or absence of vacuole sign, bubble lucency and pleural retraction (P>0.05).

CONCLUSIONSPreinvasive lesions can be accurately distinguished from MIA by the size of lesion, size of solid portion,solid proportion and morphological characteristics of the lesion edge. The size of lesion, size of solid portion, content of solid proportion and morphological characteristics of the lesion edge are of significance in the differential diagnosis of preinvasive lesions and minimally invasive adenocarcinoma of the lung.

Adenocarcinoma ; diagnostic imaging ; pathology ; Diagnosis, Differential ; Humans ; Lung Neoplasms ; diagnostic imaging ; pathology ; Multidetector Computed Tomography ; Neoplasm Invasiveness ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity