OBJECTIVE: To discuss the countermeasures in enforcing medical intellectual property rights strategy in China. METHODS: The urgency and status quo of enforcing medical intellectual property rights strategy in China were analyzed, and the corresponding countermeasures were put forward. RESULTS & CONCLUSION: Speed up the enforcement of medical intellectual property rights strategy is the only way toward developing medicine economy and improving our international competition edge.

OBJECTIVE: To provide references for promoting the development of Chinese bio-pharmaceutical industry. METHODS: The development of American bio-pharmaceutical industry was analyzed, and their advanced experiences on bio-pharmaceutical industry policy were investigated and drawn. RESULTS & CONCLUSION: Bio-pharmaceutical industry policy is essential in ensuring fast development of bio-pharmaceutical industry. Based on the advanced experiences drawn from American, together with the practicality, we should formulate bio-pharmaceutical industry development policy that tailored to our own specific condition.

The effects of interferon-? (IFN-?) on chronic myelogenous leukemia cells were studied in vitro by long-term bone marrow culture(LTBMC). There were no inhibition of cellularity from non-adherent layers and formation of adherent layers, however, CFU-GM from non-adherent layers was inhibited at IFN-? 103U/ml and 104 U/ml groups, when IFN-?was added only at initiation of culture. If IFN-? was continuously added weekly, the cellularity and CFU-GM of non-adherent layers were significantly inhibited, and the formation of adherent layers was inversely associated with the increasing concentration of IFN-?. in addition, Ph(+) cells in non-adherent layers were disappeared early and the percentage of Ph(-) population was increased with the combination of IFN-? and LTBMC. It is concluded that IFN-?selectively inhibits the later CFU-GM of CML cells and the development of stromal cells, the combination of IFN-?and LTBMC might exert a synergically purging effect on Ph(+) CML cells

Objective To explore the expression and significance of adhesion molecules ?2 integrin CD11c, CD18 in the polymorphonuclear neutrophils (PMN) and mononuclear leukocytes (MNL) of peripheral blood in patients with acute ischemic stroke (AIS).Methods Using indirect immunofluorescence and adopting a flow cytometry, the expressions of CD11c, CD18 in PMN and MNL in peripheral blood were measured within 72 h and 7 d after onset in 28 patients and 28 healthy controls.Results In AIS group, the expressions of CD11c, CD18 in PMN and MNL within 72 h ( 20.82?5.88, 218.25?89.00, 34.78?14.56 and 286.75?95.50, respectively) and at 7 d ( 18.60?5.52, 185.52?68.44, 31.97?14.47and 247.00?88.06, respectively) were significantly higher than those of normal control group ( 15.63?3.01, 150.76?41.20, 20.20?8.50 and 186.38?52.97, respectively)(all P

Hormone ingredient in the egg oil, egg and Oviductus Ranae of Rana temporaria chensinensl is David were studied as well as the effect of egg-oil on platelet aggregation and blood lipid.Results proved that the estradiol content in the egg-oil is very high.The egg-oil can obviously inhibit blood platelet aggregation and showed an hypolipemia activity. It is expeetedthat the egg-oil of R. temporaria chensinensis can be developed as an efficient medicine for the prevention and cure of atherosclerosis and hyperlipemia in elderly.

Humans ; Phosphorus Compounds ; toxicity ; Poisoning ; therapy

0 05). The forelimb functional tests demonstrated that, the number of food pellets eaten by PD rats with the contralateral side of 6 OHDA lesion (17 71?4 82) was significantly reduced compared with the controls (34 43?3 55)( P

Background Orbital tumor has complex histological types and it is difficult for clinical differential diagnosis.Therefore, it is badly in need of a new diagnostic technology to distinguish its benign and malignancy.Objective This study aimed to analyze and compare the characteristics of contrast ultrasound image between benign and malignant orbital neoplasms and evaluate the diagnostic value of contrast ultrasound to orbital tumor.Methods The clinical data of 24 patients with malignant orbital neoplasms and 51 patients with benign orbital neoplasms were retrospectively analyzed in Taihe Hospital of Hubei University of Medicine from September 2010 to September 2013.Contrast ultrasound examination was carried out on all the patients using MyLab Twice color ultrasonic device under the informed consent.SonoVue solution of 2.0 ml was intravenously injected and then the state and dynamic graphs of orbital tumors were collected.According to the classification of enhanced levels and patterns,the imaging features of orbital neoplasms were evaluated, and time-intensity curve (TIC) and dynamic vascular pattern (DVP) curve were obtained with SonoLiver software.The general ultrasonic signs and contrast ultrasonic characteristics between benign and malignant neoplasms were compared.Results Hyper-enhanced lesions were found in 62.5％ (15/24) and 27.5％ (14/51) ,and iso-intensity lesions were found in 20.8％ (5/24) and 49.0％(25/51) in the malignant orbital neoplasm patients and benign ones, respectively, with a significant difference in enhanced types between them (x2 =26.40,P＜0.01).Based on the enhanced mode, heterogeneity enhancement lesions were found in 75.0％ (18/24) and 25.5％ (13/51), and hemogeneity enhancement lesions were seen in 25.0％(6/24) and 47.1％ (24/51) in the malignant orbital neoplasm patients and benign ones, respectively, showing a significant differnee between them (x2 =30.40, P ＜ 0.01).The 58.3％ patients showed rapid rising and sharp descending TIC curves,and 75.0％ patients showed the biphasic wave DVP curves in the malignant lesions;while in the benign lesions,the TIC curves of 78.7％ patients were quick lift and slow dessend, and the DVP curves of 74.5 ％patients appeared to be positive phasic wave.These curve features were significantly different between the malignant lesions and benign ones (TIC:Z=-3.130,P=0.002;DVP:Z =-4.730,P =0.000).Conclusions Contrastultrasound examination shows that different tissue-derived orbital neoplasms have varied enhanced modes and types.Contrast-ultrasound examination is helpful for the differential diagnosis of orbital neoplasms.

Objective To evaluate the ability of contrast-enhanced ultrasonography (CEUS ) compared to enhanced MRI scan in differential diagnosis of benign and malign tumor of orbit.Methods CEUS and enhanced MRI was performed in 74 patients with tumor of orbit.These patients were divided into two groups:benign and malignant tumor depended on histological diagnosis.The results were analysed with SonoLiver software.The coincidence rate of diagnosis and enhancement intensity among CEUS,MRI and CEUS+ MRI were compared and the quantitative parameters of CEUS were analysed.Results (1 )The diagnostic accordance rate of benign group by three methods were 90.0%,80.0% and 96.0% respectively, there was statistical difference for diagnostic coincidence rate between the MRI and CEUS+ MRI(P <0.05).The diagnostic accordance rate of malignant group by the above three methods were 75.0%,79.2%and 95.8% respectively,there was no statistical difference for diagnostic coincidence rate between the three methods(all P > 0.05 ).(2 )The enhancement intensity of CEUS was different between benign and malignant groups (P <0.05).There was no statistical difference between benign and malignant groups by MRI method (P >0.05).(3)The parameters of tumor imaging obtained time intensity curve(TIC):rise time (RT),half elution time and time to peaking (TTP)were significantly different between benign and malignant groups(P <0.05).While there was no significant difference of parameters as mean transit time (mTT)and arrived time (AT)(P >0.05).Conclusions CEUS had higher diagnostic accuracy than MRI in benign orbital tumor.The contrast enhancement intensity and time-intensity curves provide valuable diagnostic information for differential diagnosis of benign and malignant orbital tumor.