1.Effect of "Shen Yan Yi Qi Solution" on renal function and histopathology of rats suffering from an experimental nephrotoxic serum nephritis
Keling LI ; Qian WANG ; Yimin GENG ; Xiaohong LI ; Hongjian KANG ; Min WEI ; Qifu HUANG ; Jing YAN ; Wenron WANG
Chinese Journal of Pathophysiology 1986;0(02):-
AIM: To investigate the therapeutic effects of "Shen Yan Yi Qi Solution",a chinese Medicine,on nephrotoxic serum nephritis in the rat. METHODS: Nephrotoxic serum nephritis model of the rat was set up by the Clarke's method. RESULTS: Proteinuria and renal insufficiency occurred in all rats after nephrotoxic serum (NTS) injection,but symptoms in treatment group were reduced. At 2nd week,the typical linear deposition of IgG along the glomerular basement membrane (GBM) was observed by fluorescence microscopy. Mesangial hyperplasia and crescent formation in glomeruli were also observed by light microscopy. In treatment group,all the above lesions were alleviated. CONCLUSION: It demonstrated that "Shen Yan Yi Qi Solution" might alleviate the pathological change of glomeruli and improve renal function.
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