Objective To explore MR features of periventricular leukomalacia(PVL) in premature infants. Methods The clinical and MR data of 30 cases with premature infant PVL were analyzed retrospectively.Results In 30 cases with PVL,the gestational age was 28~31 weeks in 18 cases,32~35 weeks in 9 cases and 36~38 weeks in 3 cases.Clinical presentations included limbs palsy in 30 cases,cortex blind in 6 cases mental retard in 14 cases and epilepsy in 8 cases.At early and medial phase,the white matter lesions at periventricular appeared as long T1 and T2 signal with blured borderline,the boundary of white-gray was blured.According to the criterion,the mild,moderate and severe cases was 11,18 and 1 respectively.Conclusion PVL is a main factor of cerebral palsy, MRI has a characteristic manifestations of PVL.

Objective To investigate the effect of perioperative fluid therapy on blood glucose in the neonates undergoing gastrointestinal operation. Methods Sixty-four ASA Ⅰ or Ⅱ neonates undergoing gastrointestinal operation were randomly divided into 4 groups ( n = 16 each). Group Ⅰ received water orally 2 h before operation and iv infusion of acetated Ringer's solution during operation. Group Ⅱ received water orally 2 h before operation and iv infusion of 2% glucose (in normal saline) during operation. Group Ⅲ received 10% glucose 5 ml/kg orally 2 h before operation and iv infusion of acetated Ringer's solution during operation. Group Ⅳ received 10% glucose 5 ml/kg orally 2 h before operation and iv infusion of 2 % glucose (in normal saline) during operation. Blood sam ples were collected from radial artery for determination of blood glucose concentrations at the beginning of fluid therapy (T0), immediately after induction of anesthesia (T1), at the beginning of operation (T2), and at 20,40and 60 min (T3-5) and 2 h after operation ( T6 ). MAP and HR were also recorded simultaneously. The blood lactic acid concentration was determined at T0 . Results There was no significant difference in MAP and HR among the 4 groups. Compared with group Ⅰ , blood glucose concentrations were significantly increased at T4-6 in group Ⅱand Ⅳ, but no significant change was found in blood glucose concentrations at each time point in group Ⅲ. There was no significant difference in blood glucose concentrations between group Ⅱ and Ⅳ. The blood lactic acid concentration was significantly higher in group Ⅲ than in group Ⅰ , and in group Ⅳ than in group Ⅱ . Conclusion Oral 10% glucose 5 ml/kg before operation and iv infusion of 2% glucose (in normal saline) during operation is beneficial for the stabilization of blood glucose levels in neonates undergoing gastrointestinal operation.

Objective: To study the effects of ulinastatin (UTI) on lung function after cardiopulmonary bypass. Methods: 60 patients, ASA score II～III, scheduled for elective cardiac valvular replacement, were randomly allocated into three groups. Study group (group I, n=20), UTI 10?000 U/kg group (group II, n=20), and UTI 20?000 U/kg group (group III, n=20). OI, V_D/V_T, P(A-a)O_2, CaO_2 , SaO_2 and PaO_2 were studied respectively. Ventilation time, simultaneous breath frequency within 24 hours after extubation and respiratory changes were also observed. Results: Compared with pre-CPB, in group I, postoperative OI, V_D/V_T, P_ (A-a) O_2 increased and CaO_2, SaO_2, PaO_2 decreased, respectively (P

Objective To investigate short-term effects of laparoscopic liver lobectomy for the treatment of hepatocellular carcinoma. Methods A comparison was made between 17 cases of laparoscopic liver lobectomy (segmentectomy) (Laparoscopic Group) and 22 cases of open hepatectomy (Open Group) from January 2001 to June 2004. The operative time, blood loss, blood transfusion amount, liver functions and blood picture before and after the surgery, and complications between the two groups were compared respectively. Results The operative time was longer in the Laparoscopic Group (median, 300 min) than in the Open Group (median, 145 min) ( u =107.05, P =0.023). Both groups presented a similar appearance in the blood loss and the blood transfusion amount. Serum levels of bilirubin and ALT varied within narrower limits in the Laparoscopic Group than in the Open Group. No significant difference was seen in blood pictures before and after the surgery in both groups. No complications happened in the Laparoscopic Group, whereas 4 cases of complications were observed in the Open Group (1 case of incision infection, 1 case of hydrothorax, 1 case of subphrenic dropsy, and 1 case of postoperative bleeding). Conclusions Laparoscopic liver lobectomy (segmentectomy) for hepatocellular carcinoma is minimally invasive, safe and effective.

Objective To assess the lung inflammatory response to cardiopulmonary bypass (CPB). Methods Twenty ASAⅡ-Ⅲ patients of either sex (9 male, 11 female) aged (43 ? 12)yr, undergoing elective cardiac valve replacement were studied. Patients with liver or kidney dysfunction and lung inflammatory diseases were excluded. Premedication included intramuscular morphine 5mg and atropine 0.1mg. Anesthesia was induced with propofol 1.5-2.0mg? kg-1, fentanyl 5?g?kg-1 and vecuronium 0. 1mg?kg-1 and maintained with isoflurane (

5000 copy/ml were both significantly higher than those in the controls.The levels of HBV-DNA positive in cultured supernatants of PBMC from suffering grave hepatitis B were higher than those in the sera by qualitative PCR of the same period.They were similar between the positive rate of quantitative PCR of HBV-DNA in sera and FQ-PCR in cultured supernatants of PBMC from hepatitis B types.They were not obviously related with the levels of ALT and TBiL.Conclusions The IL-12 and ? IFN secretion increased when the HBV-DNA of PBMC from carriers of HBeAg were at high-reproducing state.The HBV-DNA positive rate in cultured supernatants of PBMC of grave hepatitis detected by FQ-PCR was higher than that in sera by qualitative PCR.

Objective To investigate the relationship between perioperative allogeneic blood transfusion and postoperative infection. Methods The records of 213 consecutive patients undergoing elective radical resection of colorectal cancer at the first Affiliated Hospital of Zhongshan University from January 1st, 2001 to December 31st, 2001 were reviewed. The association of allogeneic blood transfusion with postoperative infection was analyzed by logistic regression. Correction for multiple analysis were made to eliminate the effects of confounding factors. Results Among the patients who received transfusion the incidence of postoperative infection was higher than that among those who received no allogeneic blood ( P

Objective: To observe two methods of cardioplegia under intrograde and retrograde, using mixed hypothemic blood in 59 patients receiving coronary artery bypass graft (CABG). Method:During perioperation and postoperation 24 hours,hemodynamie parameters were recorded. Myocardial enzyme level,the changes of ECG on 12 leads in postoperation,the frequency of using inotrope,time of staying in ICU and automatical reovery heart beat rate after openning aortic clamp were tested. Result: Cardioplegia by mixed hypothemie blood had better protective effects to the heart function, all patients could left the ICU safely,without significant differences between the two methods of cardioplegia,but in the retrograde group,there was obvious reduce in the change of myocardial enzyme level and less change of ECG in postoperation compared with those in the intrograde group. Conclusion:Both methods of mixed hypothemic blood for cardioplegia in CABG can protect effetively myocardium, but retrograde eardiaoplegia has better effect.

Objective To observe the changes of systemic and pulmonary hemodynamics during veno-venous bypass in liver transplantation Methods During the anhepatic phase, extracorporeal veno-venous bypass (EVVB) was utilized in 20 patients undergoing live transplantation Systemic and pulmonary hemodynamics were monitored through Swan-Ganz catheter during whole procedures Results As compared with the preoperative values , MAP remained unchanged in normal range during perioperative period;CO,CI,LVSW and RVSW decreased significantly during anhepatic phase and increased markedly 15 min after hepatic reperfusion (P

005) As compared with those before operation ERO_2, VO_2I, DO_2 and DO_2I increased significantly during early neohepatic stages (P