The resource limitation, ineffective utilization and severe waste generated during processing restrict the sustainable development of the Chinese herbal medicine industry. The main reasons lie in insufficient utilization of medicinal components as well as few and outdated technologies. Integration and optimization of serial technologies including pretreatment, extraction, conversion and waste treatment are the keys to solve these issues. In this article, the updated research progress and technology development of biorefinery engineering for herbal medicines are reviewed. Guided by multi-products oriental fractionation refining, Chinese herbal medicine refinery technical system is constructed relied on advanced refinery technology platforms.
Bioengineering ; Chemical Fractionation ; Chemistry, Pharmaceutical ; Drugs, Chinese Herbal ; chemistry ; Medicine, Chinese Traditional ; Plants, Medicinal

Inspect the anchorage molars with band and the anchorage molars with buccal tube with dental plaque index and gum in- dex and then statistically process the objective data obtained.The results show that both wearing band and wearing buccal tube lead to dental plaque.The influence is less worse on the the anchorage molars with buccal tube.

Objective To evaluate the reason why patients can not continue or complete the periodontal treatment stage of maintenance.Methods To communicate well with 136 patients who were diagnosed periodontitis to know why they can not continue or complete the periodontal treatment stage of maintenance.Results How deep the patients know about the importance of the stage of maintenance is the main reason to stop them continue or complete the stage of maintenance therapy.Conclusions To communicate well with periodontal patients can make them know much about periodontitis and they can complete periodontal treatment plan better.

Objective To evaluate the result of appliance of Periocline treating acute topical type periocornitis of wisdom tooth with clinical observation examination. Methods 127 cases that were clinical diagnosed acute topical type periocornitis of wisdom tooth was randomly assigned of two groups, treatment group with Periocline after rising. The contrast group with iodoglycerin after rinsing.Results The curative effect with Periocline was obviously better than that in the contrast group. The efficacy was significantly(P

Obiective To study the value of procalcitonin (PCT) and C-reaction protein (CRP)in the diagnosis of bacterial infection.Methods PCT and CRP in 2120 patients were retrospectively analyzed.Receiver operating characteristic (ROC) curve was used to compare the diagnostic capacity between two indices.Correlation between PCT and CRP was analyzed among 178 patients with bacterial infection.Results Areas under ROC curve (AUC) were 0.957 ±0.016 for PCT and 0.712 ± 0.04 for CRP.There was statistical significance of the AUC for PCT and CRP.The optimum cutoff value for PCT was 0.4 μg/L,which had a sensitivity of 90.0％ and a specificity of 90.9％.The optimum cutoff value for CRP was 2.27mg/L,which had a sensitivity of 72.0％ and a specificity of 57.3％.In the 2120 patients,there was the situation which PCT was normal (＜0.1 μg/L) when CRP was normal (＜0.8 mg/L).Conclusions In prediction of bacterial infection,CRP was not good,but PCT had high clinical value because of rapid detection,less interference and high specificity.In suspected bacterial infection patients,PCT was considered not to be detected temporarily if CRP was normal.In this way,there was the economic value which the patient's medical costs may be Controlled and medical resources be saved.Combined with its half-life,monitoring and analyzing the PCT change is valuable for efficacy determination and assessment of the patients'conditions.

Melatonin holds a wide range of biological effects, its multi-channel and multi-target impacts on reproductive sys-tem are the basis of pregnancy related rhythm, including conception, the duration of pregnancy and delivery.This paper describes the synthesis of melatonin, the characteristics of melatonin receptors distribution and melatonin′s biological property.It also illuminates the influence of melatonin rhythm on the above-mentioned courses, hoping to provide theory basis for clinical suggestions to modulate rhythm around pregnancy.

Objective To observe the effect of application in canicular days on the quality of life and immune substances in patients with allergic rhinitis (AR), and its therapeutic efficacy for AR. Method Sixty-four AR patients were divided into a treatment group of 34 cases and a control group of 30 cases by using the random number table. The treatment group was intervened by acupoint application in canicular days, while the control group was by placebo adhered to the same points. The Short-Form (36) Health Survey (SF-36) and Self-rating Rhinitis Scale (RS) were evaluated before and after the intervention; the serum total immunoglobulin E (T-IgE) and eosinophil cationic protein (ECP) were detected before and after each treatment session, and the changes of the parameters were compared. Result The global scores of SF-36 and RS, and the level of serum ECP were significantly changed after intervention (P<0.05); there was no significant change in serum T-IgE after treatment (P>0.05). Conclusion Application in canicular days can promote the quality of life, improve rhinitis symptoms, and down-regulate the level of serum ECP, indicating that application in canicular days can produce a satisfactory efficacy in treating allergic rhinitis.

We used domestic perfluorotributylamine to treat 21 eyes with giant retinal tears, including 5 rhegmatogenous retinal detachment with folded and fixed flap and 16 giant retinal tears resulting from retinotomy and retinectomy due to complicated retinal detachment. The success rate of retinal reattachment was over 95%, with no serious side effects. The activities and complications of perfluorotributylamine in the mangement of giant retinal tears were discussed.

Objective To supply scientific basis for the reasonable development and utilization of Rubus multibracteatus Levl.et Vant.resources.Method The total flavonoids was extracted from Rubus multibracteatus Levl.et Vant.with 60% methanol and its content was determined by spectrophotometry.The reliability and repeatability of the method were tested through stability,repeatability,accuracy and recovery experiments.Result Both standard and tested solutions had the maximum absorbance at 510 nm.The RSD values of repeatability,accuracy and recovery experiments were 2.11%,0.97% and 2.4% respectively.The results of content determination showed that the total flavonoids in Rubus multibracteatus Levl.et Vant.was 3.8%.Conclusion Extracted with 60% methanol,colored with aluminiumnitrate and determined by spectrophotometry at 510 nm were suitable for the determination of total flavonoids in Rubus multibracteatus Levl.et Vant..

Objective To investigate factors influencing thyroid stimulating hormone (TSH) and phenylalanine (phe) assay in dry blood spots on filter paper. Methods The influence on enzyme linked immunoassays and bacterial inhibition assay were studied so as to control their changes. Results Many influencing factors were noted in newborn screening assay. TSH results were stable if specimens were collected form newborns 72 hours after delivery. Different results were obtained when TSH was tested in different seasons. Specimens were air dried at room temperature before transportation. To reduce false positive phe result, specimens were collected from newborns 72 hours after delivery. The phe result was very stable with a plating temperature of 55 60℃ and speradical distribution of blood spots . Conclusion To assure the quality of screening the time of specimens collecting, different cut off, blood spots disposition and best condition should be controlled.