0.05).The major toxicity and side effects were bone marrow inhibition,gastrointestinal reaction and mucosal reaction.The difference of hematologic toxicity and gastrointestinal between the two groups was statistically significant(P0.05).The GEM group could be well tolerated for the concurrent chemoradiotherap of patients with stage Ⅲ～Ⅳa nasopharyngeal carcinoma(NPC).

This article was aimed to study the therapeutic effect of Chinese medicine Kun-Bao-W an (KBW) on sleep disorders among ovariectomized mice. A total of 60 female KM of adult mice were randomly divided into four groups, which were the sham-operated group, model group, diazepam group, and KBW group, with 15 rats in each group. Rats in the sham-operated group were only removed small amount of fatty tissue around the ovaries. Bilateral oophorectomy was given on mice in other groups. In the KBW group, 28 days after the operation, KBW was intragastrically administered (1.667 g·kg-1) every day for 28 days. Mice in the diazepam group were intragas-trically administered (1.25 g·kg-1) 1 h before testing. The observation was made on effects of KBW on locomotor activity, sleeping time of mice induced by pentobarbital sodium and the organ coefficients of uterus. The results showed that compared with sham-operated group, locomotor activity and rearing behavior increased obviously in the model group (P < 0.01). The diazepam group can significantly reduce locomotor activity in ovariectomized mice (P < 0.01), and decrease the number of rearing behavior mildly with no statistical difference. KBW can reduce lo-comotor activity mildly but without effect on rearing behavior in ovariectomized mice. Diazepam can markedly pro-long the pentobarbital sleep time in ovariectomized mice (P < 0.01). KBW can prolong the pentobarbital sleep time and shorten the process of falling into sleep mildly with no statistical difference. There was no significant ef-fect on organ coefficients of uterus in ovariectomized mice by KBW or diazepam. It was concluded that KBW had mild effect on improving sleep disorders in ovariectomized mice.

This article was aimed to study the sedative and hypnotic effects of different eluents of Shuangxiatang (SXT). The effects of SXT water decoction, water eluent, 20%, 70% and 95% alcohol eluent on spontaneous ac-tivity and the sleeping induced by subthreshold dose of pentobarbital sodium were measured. The results showed that the SXT decoction, 20% and 95% alcohol eluent can significantly decrease the number of rearing in mice with the percentage of 78.5%, 78.3% and 62.5%, respectively. SXT water eluent and 70% alcohol eluent can significantly decrease the spontaneous activity of mice (P < 0.01), the number of rearing (P < 0.01) and grooming time (P < 0.05). SXT water decoction can significantly shorten sleep latency (P < 0.05), prolong sleep time (P <0.05), and increase rates of sleeping in mice. SXT water eluent can significantly shorten sleep latency in mice (P< 0.05), increase rates of sleeping in mice. SXT water decoction and water eluent have the sedative and hypnotic effects. And the effects are more than alcohol eluents.

Objective To explore the relationship between MspⅠpolymorphism of CYP1A1 gene and susceptibility to breast cancer in Yi nationality in Yunnan province. Methods The gene polymorphism of restriction enzyme of 3′-terminal of CYP1A1 was detected by PCR-RFLP in 60 healthy Yi women , 51 Yi women with breast cancer, 235 healthy Han women, and 250 Han women with breast cancer. Results The distribution frequency of CYP1A1-MspⅠgenotypes was significantly higher in Yi women with breast cancer (51.0%) than in the healthy Yi women (33.3%) (P < 0.05), an the allele C had a higher frequency in women with breast cancer than in healthy controls (P < 0.05). Significant differences of frequencies were found in genotypes TT, TC and CC between women with breast cancer and healthy controls (P < 0.05). The risks of TC and CC for breast cancer were 1.19 and 1.95 folds respectively to TT genotype. But as compared with Yi women , the distribution frequency of CYP1A1-MspⅠ genotypes did not differ between Han women with breast cancer and in the healthy control (P > 0.05), and there were no differences in three genotype frequencies (P > 0.05). Conclusions Gene polymorphism of CYP1A1 genotypes may be associated with the risk of breast cancer in Yi nationality but not in Han nationality in Yunnan. The mutation of CYP1A1 gene may increase the incidence of breast cancer in Yi nationality.

Objective To learn 2009~2014 Shaanxi Province sentinel surveillance six classes of HIV infection focus groups, and estimates of HIV-1 new infection.Methods Used enzyme-linked immunosorbent assay (ELISA)and Western blot (WB)experiments for the 2009~2014 HIV sentinel surveillance Shaanxi Province Category 6 focus groups conducted a total of 77 778 HIV antibody screening and confirmatory testing estimates of HIV-1 new infection.Results 2009~2014 men who had sex with men and people with HIV infection rate were 3.75%,8.77%,3.50%,5.00%,6.20% and 5.75%,and a slow upward trend;HIV-1 new infection were 5.04%,8.96%,5.01%,5.95%,4.68% and 6.39%,the overall downward trend. Young students,drug addicts,sex workers,pregnant women,and male STD clinic attenders five people with HIV infection and HIV-1 new infection were emerging to remain low.But male STD clinic attenders of HIV infection and HIV-1 new in-fection was emerging slowly rising trend.Conclusion Shaanxi MSM HIV infection and HIV-1 new infection were high,but HIV-1 new infection had decreased slowly.Emerging trend should continue to increase the population of the intervention ef-forts.The infection rate in other monitoring population was relatively low but a few people on the rise,the need to take the necessary coping methods.

Objective To evaluate the values of continuous subcutaneous insulin/rapid insulin analoguc infusion in desensitization for allergy to recombinant human insulin. Methods Two patients allergic to recombinant human insulin received desensitization therapy by continuous subcutaneous insulin lispro infusion. The diluted insulin lispro solution was pumped with initial basal rate of O. O1 U/h, and the basal rate and insulin lispro concentration increased gradually until the insulin dosage for clinical treatment was reached. After that, continuous subcutaneous insulin lispro infusion was replaced by regimen of insulin lispro subcutaneous injection plus oral hypoglycemic agents. Results Local wheals were not observed in both two patients during continuous subcutaneous insulin lispro infusion or during bolus subcutaneous injection of insulin lispro after desensitization. Conclusion The desensitization therapy by continuous subcutaneous insulin/rapid insulin analogue infusion can be applied for allergy to recombinant human insulin.

Objective:Analyzing the core position of hospital in value-based healthcare practice and designing IT platform to support value medicine practice.Methods:Based on the orchestral model and the enterprise architecture theoiy,making the hospital as the leading part of the practice of value-based healthcare,taking value-based healthcare as the business strategy,standing on the advance of value-based healthcare in China,considering fully of the existing organizational inertia on business,IT foundation and IT implementation mode based on the software prototype development method in hospital,it manages to establish an IT architecture dominated by the business operations and supplemented by business strategies.Results:The hospital IT application architecture was built around the five themes of"one-stop integrating all service,four-stream integrating to promoting business operation,reducing the cost of major supplies,scientific management and cost controlling,and evaluating the healthcare value by the total data".Conclusion:A feasible and practical hospital IT application architecture oriented to value-based healthcare is designed,which provides an reliable guidance for the hospital to push forward the value-based healthcare.

Objective:Analyzing the core position of hospital in value-based healthcare practice and designing IT platform to support value medicine practice.Methods:Based on the orchestral model and the enterprise architecture theoiy,making the hospital as the leading part of the practice of value-based healthcare,taking value-based healthcare as the business strategy,standing on the advance of value-based healthcare in China,considering fully of the existing organizational inertia on business,IT foundation and IT implementation mode based on the software prototype development method in hospital,it manages to establish an IT architecture dominated by the business operations and supplemented by business strategies.Results:The hospital IT application architecture was built around the five themes of"one-stop integrating all service,four-stream integrating to promoting business operation,reducing the cost of major supplies,scientific management and cost controlling,and evaluating the healthcare value by the total data".Conclusion:A feasible and practical hospital IT application architecture oriented to value-based healthcare is designed,which provides an reliable guidance for the hospital to push forward the value-based healthcare.

Objective:Analyzing the core position of hospital in value-based healthcare practice and designing IT platform to support value medicine practice.Methods:Based on the orchestral model and the enterprise architecture theoiy,making the hospital as the leading part of the practice of value-based healthcare,taking value-based healthcare as the business strategy,standing on the advance of value-based healthcare in China,considering fully of the existing organizational inertia on business,IT foundation and IT implementation mode based on the software prototype development method in hospital,it manages to establish an IT architecture dominated by the business operations and supplemented by business strategies.Results:The hospital IT application architecture was built around the five themes of"one-stop integrating all service,four-stream integrating to promoting business operation,reducing the cost of major supplies,scientific management and cost controlling,and evaluating the healthcare value by the total data".Conclusion:A feasible and practical hospital IT application architecture oriented to value-based healthcare is designed,which provides an reliable guidance for the hospital to push forward the value-based healthcare.

Objective:Analyzing the core position of hospital in value-based healthcare practice and designing IT platform to support value medicine practice.Methods:Based on the orchestral model and the enterprise architecture theoiy,making the hospital as the leading part of the practice of value-based healthcare,taking value-based healthcare as the business strategy,standing on the advance of value-based healthcare in China,considering fully of the existing organizational inertia on business,IT foundation and IT implementation mode based on the software prototype development method in hospital,it manages to establish an IT architecture dominated by the business operations and supplemented by business strategies.Results:The hospital IT application architecture was built around the five themes of"one-stop integrating all service,four-stream integrating to promoting business operation,reducing the cost of major supplies,scientific management and cost controlling,and evaluating the healthcare value by the total data".Conclusion:A feasible and practical hospital IT application architecture oriented to value-based healthcare is designed,which provides an reliable guidance for the hospital to push forward the value-based healthcare.