Objective To study the facial cosmetic zonation and its application of adipose injection for facial juvenescence.Methods According to standard of aesthetics,we divided total face into ten cosmetic units and 49 cosmetic sub-units.23 patients,injected adipose for facial juvenescence,were evaluated.Results 149 cosmetic units from 23 patients were injected with adipose granules,and involved 300 sub-units.Each unit was injected with adipose from 1 to 35 ml.After injection,the faces showed swelling in varying degrees,which resolved from ten to fourteen days.Local ecchymosis occurred in 11 cases,and resolved from five to twenty days.No any complication appeared,such as infection,scleroma and vascular embolism and so on.The follow-up results showed that one month later post-operation,swelling on injective sites resolved,and appearances were stable.3-6 months later post-operation,the injective sites were fuller.One year later,the good j uvenescence effect achieved,and the patients felt satisfactory.Conclusions On the basis of facial cosmetic zonation,the whole cosmetic evaluation combined with local cosmetic evaluation might be helpful to carry out adipose injection for facial juvenescence,and reach a satisfactory result.