OBJECTIVE:To establish a method for determination of the dissolution of cibenzoline succinate tablets. METHODS: The content of cibenzoline succinate was determined by HPLC and computed based on the peak area in the external reference method. The chromatographic column was Diamonsil C18. The mobile phase consisted of acetonitrile-phosphoric acid(40∶60). The detective wavelength was set at 230 nm. The dissolution was determined by paddle method. RESULTS: The linear range of cibenzoline succinate was 1～40 ?g?mL-1(r=0.999 9) and the average recovery rate was 97.70%(RSD=0.14%).The dissolution rates of 3 batches of samples at 15 min were all above 80%.CONCLUSION: The established method is simple,rapid and accurate,and it is applicable for the determination of the dissolution of cibenzoline succinate tablets.

Objective To study the 5 years contraceptive efficacy of levonorgestrel intrauterine system (LNG-IUS) and the ovarian functions in amenorrhea women. Methods LNG-IUS and TCu 380A IUD were randomly inserted in 2 groups of women, 50 each. Women were followed annually for 5 years. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E 2), and T levels in 14 women with amenorrhea, and endometrial biopsies were obtained in 9 cases. Results By the end of 5 years, there were 2 pregnancies in TCu 380A group, but none in LNG-IUS group; and 24 amenorrhea cases in LNG-IUS. The 5 year cumulative continuation rates were 24% for LNG-IUS and 78% for TCu 380A ( P

Whole-body vibration (WBV) training is a kind of new technology on the practice of rehabilitation medicine and is used to improve muscle strength, mobility, balance, osteoporosis, sarcopenia, metabolic syndrome and osteoarthritis in aging adults. The definition, safety, effectiveness, and biomechanics of WBV training were reviewed in this paper.

Whole-body vibration therapy (WBVT), in which energy produced by a forced oscillation is transferred to the muscle and bone of an individual from a mechanical vibration platform, has been proposed as an alternative or adjunctive intervention for osteoporosis. In this review, the safety, effectiveness and the biomechanics of WBVT for the prevention and treatment of osteoporosis were discussed.

Virtual reality (VR) offers the possibility of creating an interactive, motivating environment in which training intensity and feedback can be manipulated to provide individualized treatments or motor rehabilitation under a range of stimulus conditions that are not easily controllable and quantifiable in the real world, especially in elderly. This paper reviewed the studies illustrating the application, development and effectiveness of VR on rehabilitation in the elderly, that suggested VR may be useful to augment rehabilitation of a range of disabilities in elderly patients. The prospect of VR is discussed as well.

BACKGROUND:Previous studies show that the fracture resistant force of endodonticaly treated teeth can be improved by post. But this idea has been controversial in recent years. Many scholars believe that the root canal preparation might weaken dental root the post increases the risk of tooth fracture. OBJECTIVE: To evaluate the fracture resistance ability of severe wedge-shaped-defect premolar to oblique loading, which was restored with fiber reinforced composite posts by different therapy methods. METHODS:A total of 50 human maxilary premolars were randomly divided into five groups, with ten teeth in each group. They were given folowing treatments: Group A: 10 untreated premolars; Rest 40 premolars of Groups B, C, D and E were prepared 1/3 bucco-lingual distance for artificial severe wedge-shaped defects at the buccal cervix. Group B: untreated severe wedge-shaped defects premolars; Group C: severe wedge-shaped defects premolars were endodonticaly treated, remaining dentin over hang above the wedge shaped defect, LuxaPost posts reinforced in buccal canal and lingual canal, LuxaCore composite resin restored dentin defect; Group D: severe wedge-shaped defects premolars were endodonticaly treated, LuxaPost posts reinforced in buccal canal and lingual canal, LuxaCore composite resin restored dentin defect, and then covered with ful metal crown; Group E: severe wedge-shaped defects premolars were endodonticaly treated, removing dentin over hang above the wedge shaped defect, LuxaPost posts reinforced in buccal canal and lingual canal, restored with LuxaCore composite resin, and then covered with ful metal crown. Fracture resistance of each specimen was measured in each group. RESULTS AND CONCLUSION: The fracture strength of each group were Group A (1 002.69±147.62) N, Group B (439.28±66.34) N, Group C (958.30±101.23) N, Group D (1 207.09±143.48) N, and Group E (1 056.44±139.30) N. Group D had the highest fracture strength (P < 0.01), while Group B had the lowest fracture strength (P < 0.01). There were no significant difference among the fracture strength of Group A, Group C and Group E. Our findings indicated that the fracture resistance of the severe wedge-shaped defected premolar can be improved by fiber reinforced composite post and dentin above wedge shaped defect remained.

Carotid artery stenosis is one of the most important reasons for stroke. Carotid artery stenting possesses more advantages with less damage and pain for patients, which has becaome the most effective treatment for carotid artery stensis, and the use of review the issues related to te carotid artery stenting under cerebral protection. With the accomplishment of many successful large scale clinical trials carried out by multiple centers, it is believed that carotid artery stenting with cerebral protection plays important orle in the prevevtion and treatment of cerebral stroke initiated by carotid artery stenosis.

Objective To investigate the posterior condylar angle(PCA) of distal femur in normal adult, and provide reasonable referenced parameters of the rotational alignment for the total knee arthroplasty in Chinese. Methods This study concluded 118 volunteers(186 knees) in Suwan area (67 males 103 knees, and 51 females 83 knees), whose knees were healthy, without any malformation. The average age was 39.7 years(range, 18-69 years). All subjects were divided into three groups according to the ages: group A, 18-39 years (85 knees); group B, 40-59 years(73 knees); group C, more than 60 years(28 knees). The CT scan was employed to the mechanical axis which was perpendicular to the knee joint in the distal femur. The PCA was measured from the CT film across lateral and medial femoral epicondyle. The factorial design was used to compare the data among three groups. Results First, in the 103 knees of male, 57 in left side and 46 in right side. The PCA were 5.9??1.6? in left side, 5.6??2.6? in right side(mean, 5.8??2.2?). Then in the 83 knees of female, 38 in left side and 45 in right side, the PCA was 5.5??2.5? in left side, 5.2??1.5? in right side(mean, 5.3??1.9?). And the PCA was 5.5??1.9? in group A, 5.7??1.8? in group B, 5.5??2.7? in group C, respectively, and there is no statistical significant difference in either gender or side and age. Conclusion The normal adult PCA of distal femur is 5.6??2.1? in Suwan area, without difference in gender, which is beyond the Westerns obviously. So in the total knee arthroplasty of Chinese, the malalignment will likely occur if the rotational alignment is performed according to Western style, the eversion 3? to the posterior condylar line in distal femur.

0.05),but the benefit was significantly different (P