1.Observation on Therapeutic Effects of Chemotherapy Involving Oxaliplatin in Treatment of Advanced Na-sopharyngeal Carcinoma
Weijian SHI ; Qiaoyun ZHOU ; Wendong JU
China Pharmacy 2005;0(24):-
OBJECTIVE:To observe the effects as well as adverse durgs reactions of chemotherapy involving oxaliplatin in treatment of advanced nasopharyngeal carcinoma(NPC).METHODS:28patients with advanced NPC underwent chemotherapy with5-Fu,tetrahydrofolic acid calcium,and oxaliplatin for21days as one cycle,the therapeutic effects were evaluated after two cycles.Meanwhile the retrospective comparative study was made between the chemotherapy and the regular chemotherapy with5-Fu,tetrahydrofolic acid calcium,and platinum.RESULTS:Similar effects were observed in both regimens.How?ever,there were great differences in incidence ofⅢandⅣgrade nausea and vomiting,as well as renal function indices(P
2.A clinical study of low molecular weight heparin on the treatment of disseminated intravascular coagulation prophase state in pregnant woman
Wendong JU ; Bo WAN ; Donge WANG ; Jun HUANG ; Ling JIANG ; Yun YE ; Lihong FENG ; Qiaoyun ZHOU ; Jianhui WU ; Shuanwen LI
Journal of Chinese Physician 2001;0(08):-
5.0mg/L were randomly divided into LMWH treatment group and low molecular dextran treatment group with 20 patients in each group.The patients in LMWH group were treated with 0.3ml LMWH subcutaneous injection in abdominal wall in every 12h for 1-4 d.The patients in low molecular dextran group were treated with 500ml low molecular dextran plus 20ml danshen root,intervenous drop infusion for 1-7d.Results The D-Dimer blood serum level in the gestational late period was significantly higher than that of nongravida group(P
3.Primary breast lymphoma:A clinical analysis of 25 cases
Fenglian JIANG ; Weijian SHI ; Wendong JU ; Qiaoyun ZHOU ; Quanyong LI ; Li WANG ; Haojie SONG
China Modern Doctor 2014;(23):141-144
Objective To improve the recognition and management of primary breast lymphoma(PBL) by discussing the clinical pathological characteristics and the prognosis of PBL. Methods The clinical and treatment records of PBL pa-tients admitted in Boai hospital of zhongshan from January 2001 to December 2012 were analyzed. Results All cases were B-cell origin(25/25),61.5%(16/25)were diffuse large B-cell lymphoma origin,The 5-year overall survival was 44%. There were no significant difference in the 5-year overall survival rates, 5-year local control rates and 5-year distant control rates in patient treatment with any surgery compared with no-Surgery(P>0.05).There were no significant difference in the 5-year overall survival rates and 5-year distant control rates in patient treatment with any RT com-pared with no-RT(P>0.05),but the 5-year local control rates was significantly different(P<0.05);There were no sig-nificant difference in the 5-year overall survival rates and 5-year local control rates in patient treatment with any chemotherapy compared with no-chemotherapy (P>0.05). but the 5-year distant control rates was significant different(P<0.05). Conclusion The prognosis of PBL is related with the clinical stage and pathological type. Radiotherapy and chemotherapy respectively promote the local control and distant control. The optimal treatment is surgery combined with chemotherapy and/or radiotherapy.
4.Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice.
Lili DING ; Qiaoling YANG ; Eryun ZHANG ; Yangmeng WANG ; Siming SUN ; Yingbo YANG ; Tong TIAN ; Zhengcai JU ; Linshan JIANG ; Xunjiang WANG ; Zhengtao WANG ; Wendong HUANG ; Li YANG
Acta Pharmaceutica Sinica B 2021;11(6):1541-1554
Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders. We have identified notoginsenoside Ft1 (Ft1) from