To study the clinico pathological characteristics of primary cardiac tumors, one hundred and fifty one primary cardiac tumors were studied pathologically. Immunohistochemical study was also performed in nineteen cases. The results showed that of all the tumors, five were malignant, and one hundred and forty six were benign, in which myxoma accounted for one hundred and fifty four. Epithelial cells forming glands were immunoreactive for keratin or epithelial membrane antigen (EMA) in two cases of myxoma, indicating epithelial differentiation. It is the authors′ opinion that clinical manifestations in combination with pathological features and immunochemical characteristics were helpful in differential diagnosis of malignant cardiac tumors