In the recent 2 decades,the clinical medical mode has been changed greatly.The experience-based medical mode is gradually replaced by evidence-based mode,ie,evidence-based medicine.Large scale clinical trials provide robust evidence for clinical practice and quality control is critical for the success of one trial.We discuss six facets on this subject,including protocol design,staff training,manual formulating,organization,data management and monitoring.The objective of quality control is to ensure the study conducted according to the protocol,the results are reliable and protect the human rights of participants.

OBJECTIVE:To study the pharmacokinetics of domestic zaleplon tablets in Chinese healthy volun?teers.METHODS:20male healthy subjects received a single oral dose of15mg zaleplon tablets.The plasma concentrations of zaleplon were determined by an improved HPLC method.RESULTS&CONCLUSION:The main pharmacokinetic parameters of zaleplon were as follow:C max was55.90?16.20ng/ml,T max was1.05?0.32h,Ke was0.74?0.18h -1 ,T 1/2Ke was1.00?0.29h,AUC 0～8 was123.70?25.64ng?h/ml,AUC 0～∞ was125.20?25.80ng?h/ml.The results are compara?ble to those reported in foreign literature.

OBJECTIVETo explore the optimal intervention time of acupuncture and moxibustion in the treatment of peripheral facial paralysis.

METHODSTwo hundred and four cases of peripheral facial paralysis were collected in clinic for retrospective analysis. According to the time between the disease onset and the intervention of acupuncture and moxibustion, 3 groups (groups A, B and C) were divided. In group A, the treatment was given in 1 to 3 days after onset; in group B, the treatment was given in 4 to 7 days after onset; in group C the treatment was given in 8 to 10 days after onset. The treatment with acupuncture and moxibustion was applied according to the regular stages of disease in the three groups. At the acute stage, the less points and shallow puncture therapy combined with distal acupoints at the limbs were adopted on the affected side. At the stable stage, the more points and shallow puncture therapy were used on the affected side. At the recovery stage, the deep puncture or penetrating punctures was applied on the affected side. The curative effects was given once every day and the treatment of 10 days made one session. The curative effects were analyzed statistically at the end of three sessions of treatments separately.

RESULTSAt the end of the 1st session of treatment, the total effective rate was 58.8% (40/68) in group A, 69.7% (53/76) in group B and 46.6% (28/60) in group C. At the end of the 2nd session of treatment, the total effective rate was 85.3% (58/68), 90.8% (69/76) and 71.6% (43/60) in group A, B and C separately. At the end of 3rd session of treatment, the total effective rates were 89.7% (61/68), 97.4% (74/76) and 83.3% (50/60) in the three groups separately. The differences were significant statistically at the same session of treatment among three groups (all P<0.05), in which, the results in group B was the best, followed by group A and C in sequence.

CONCLUSIONthe best intervention time of acupuncture and moxibustion is in 4 to 7 days after onset of facial paralysis.

Acupuncture Therapy ; Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Combined Modality Therapy ; Facial Paralysis ; therapy ; Female ; Humans ; Male ; Middle Aged ; Moxibustion ; Retrospective Studies ; Treatment Outcome ; Young Adult

Acupuncture Therapy ; Female ; Humans ; Middle Aged ; Syringomyelia ; therapy

Climate Change ; Health ; Humans ; Risk Adjustment

Adolescent ; Diagnosis, Differential ; Diverticulum, Stomach ; complications ; diagnosis ; pathology ; Gastrointestinal Hemorrhage ; diagnosis ; etiology ; pathology ; Gastroscopy ; Humans ; Male

The construction of single wireless web platform is an important condition for the development of clinical informa -tion technology .The aim of this study was to explore the construction of wireless web platform in hospital and innovative applications of medical internet based on this platform .The medical internet was applied innovatively through the construction of multi -service wireless web platform .Based on the innovative application of medical networks such as cold chain system and transfusion monitoring system , special clinical requirements were fulfilled so as to improve medical safety and medical quality .The multi-service wireless web platform can realize the integration of multi-networks and multi-systems to avoid overlapping investment and redundant construction in hospital .

After the concept of data curation and its application in foreign countries were described , the key points of data curation for data service in special libraries and related problems were analyzed according to the overall needs and changes of users in special libraries.

330 cases of impacted mandibular third molar were divided into 3 groups,A:younger than 18 years,B:18-25-year-old,C:ol-der than 25-year.Operation time(min)of group A,B and C was 21.95 ±5.86,6.45 ±4.92 and 18.77 ±9.64(B vs A or C,P <0.01), intraoperative complication rates were 2.73%,6.36% and 30.91%(P <0.01),postoperative complication rates were 51.82%,23.64%and 66.36%(P <0.05),respectively.18-25 year-old is the suitable age for removal of impacted mandibular third molars.