Child ; Evidence-Based Medicine ; Humans ; Lupus Nephritis ; diagnosis ; therapy ; Practice Guidelines as Topic

Objective To analyze the relationship between renal function impairement and obesity in patients with primary hypertension.Methods One hundred and twenty-eight primary hypertension patients with renal function impairement admitted to our hospital from January 2012 to December 2015 were divided into obesity group (n=68) and control group (n=60) according to the Asian obesity diagnosis criteria established by the International Diabetes Federation.Relationship of serum urea nitrogen (BUN),creatinine,cystatin C (Cys-C),urinary N-acetyl beta-D glucosaminidase (NAG),urinary micro albumin levels and BMI with renal function impairment in primary hypertension patients was analyzed by multivariate linear stepwise regression analysis.Results The BMI,serum levels of urinary NAG,Cys-C,BUN,and creatinine were significantly higher in obesity group than in control group (31.70±1.80 kg/m2 vs 23.95±2.00 kg/m2,19.34±1.40 U/L vs 14.92±1.31 U/L,0.69±0.06 mg/L vs 0.47±0.05 mg/L,11.50±2.90 mmol/L vs 8.60±1.90 mmol/L,159.50±10.40 μmol/L vs 148.90±10.70 μmol/L,P＜0.05).The incidence of urinary micro albumin was significantly higher in obesity group than in control group (79.4％ vs 46.7 ％,P＜ 0.01).Blood pressure,pulse pressure difference,BMI,fasting blood glucose,serum levels of ereatinine,urinary NAG,Cys-C,BUN and urinary micro albumin were the risk factors for renal function impairement in primary hypertension patients (P＜0.05,P＜0.01).Conclusion Renal function impairement is related with obesity in primary hypertension patients.

As a species of acute respiratory tract pathogen in mankind, Chlamydia pneumoniae can cause upper respiratory tract infection, pneumonia, it may also play an important role in bronchial asthma, chronic obstructive pulmonary diseases, sarcoid, lung cancer.

The organophosphorus insecticides including a large group of insecticides were widely used in the world in the agriculture and household. Over 80% of the pesticides used in China are organophosphorus pesticides. Workers and the general population may be exposed to insecticides mixtures through water,air and the residue of food. After entering into human body,the insecticide mixtures can cause a combined toxicity. In this paper,the effects and toxicity mechanisms of combined exposures on health were expounded.

The apprentice system is the principal succession method of ancient Chinese medicine. Masters pass down knowledge via verbal instructions as well as personal deeds, and apprentices are unconsciously influenced deeply within by what they see and hear from masters. That is where the strong point of the system. However, at the same time, apprentices are confined by their master’s instructions and learn only a part of the knowledge. It is the profound meaning rather than the form, that truly represents the modern value of the system. Traditional Chinese medicine stresses the cultivation of medical ethics, purification of learning motivation, study of classic works, solid foundation of basic skills and clinical practice. It also advocates that apprentices should be led and taught in accordance to his aptitude.

Objective To evaluate and compare the therapeutic effects of suprapubic transvesical prostatectomy (SPPC), Madigan prostatectomy (MPC) and transurethral electrovaporization ablation prostatectomy (TUVP) for the treatments of symptomatic BPH. Methods 216 symptomatic BPH patients randomly underwent SPPC(n=87), MPC(n=45) or TUVP(n=84) respectively and their therapeutic effects were evaluated. Results There are significant improvements in symptoms and physical signs in each group after operation. The morbidity rates of post-operative complications in SPPC,MPC and TUVP were 31 0%,11 1%,13 1% respectvely. SPPC group showed the longest average operative time and the most blood loss, both of which were the least in TUVP group. Conclusions SPPC was the most effective among the three procedures, but the trauma of SPPC to the patient was the most. Complication of MPC was the least. TUVP was the safest procedure with the least injury.

Objective:To compare the dissolution of domestic terazosin hydrochloride tablets and capsules to provide reference for clinical use. Methods:The dissolution of the products from different manufacturers was investigated respectively in 4 kinds of media:pH 1. 0 hydrochloric acid solution,pH 4. 5 phosphate buffer solution,pH 6. 8 phosphate buffer solution and water. The dissolution tests were carried out by a paddle method at the stirring speed of 50 r·min-1 and an HPLC method was used to determine the dissolution rate. The dissolution behavior of the samples from different manufacturers was compared by a similar factor method. Results:The do-mestic tablets showed higher similarity with the reference formula, and the dissolution behavior of the capsules had significant differ-ence. Conclusion:The calculation method for the specification in some manufacturers is different from that of the reference prepara-tion, which leads to the difference between the testing preparation and the reference preparation, and should be paid attention in clini-cal use.

Objective To evaluate the efficacy of combined general anesthesia with epidural block(CGEA) for choledocholithotomy in the elderly. Methods Sixty patients, ASA I-II, scheduled for elective choledocholithotomy were divided into single general anesthesia group(control group) and CGEA group(study group). Hemodynamics, general anesthesia dosage and awakening time were observed. Results In control group, patients had higher stress responses while intubated and their BP and HR were signifficantly increased after intubation(P

Objective To explore the influence of triepoxide (TPT) on the function of CD11clowCD45RBhigh dendritic cell (DC) subsets which produce IL-10. Methods Splenic CD11clowCD45RBhigh DCs and CD4+ T cells were harvested from C57BL/6 mice by magnetic bead sorting. CD11clowCD45RBhigh DCs were treated with various doses of TPT (0, 1, 10, 20ng/ml), and those without TPT as controls. Flow cytometry was used to determine the expression of CD11clowCD45RBhigh DC surface molecules including CD40, CD80, CD86, I-a/e, and IL-10 levels in CD11clowCD45RBhigh DC culture supernatants were determined by sandwich enzyme-linked immunosorbent assays (ELISA). The CD4+ T cells were divided into the following 5 groups: control group, untreated group (TPT-untreated CD11clowCD45RBhigh DC+CD4+ T cells), high-dose TPT-treated group (20ng/ml TPT-treated CD11clowCD45RBhigh DC+CD4+ T cells), high-dose TPT-treated + antibody I group (20ng/ml TPT-treated CD11clowCD45RBhigh DC+CD4+ T cells and IL-10 antibody) and high-dose TPT-treated + antibody II group (20ng/ml TPT-treated CD11clowCD45RBhigh DC+CD4+ T cells and IL-10 antibody isotype). Proliferative activity of CD4+ T lymphocytes was determined by MTT, whereas IL-4 and IFN-γ contents in CD4+ T cell culture supernatants were determined by flow cytometry. Results TPT markedly decreased the expression of CD40 and I-a/e while enhancing the expression of CD86 on CD11clowCD45RBhigh DC surface and IL-10 secretion. The enhancement of IL-10 secretion level hinged upon the rise of TPT concentration. The proliferative activity and IFN-γ secretion level in high-dose TPT-treated group and high-dose TPT-treated + antibody II group were markedly lower than those in the untreated group with significantly higher IL-4 secretion levels in TPT, whereas the proliferative activity and IFN-γ secretion level in high-dose TPT-treated group and high-dose TPT-treated + antibody I group were significantly higher than those in the untreated group with markedly lower IL-4 secretion level in TPT. Conclusions TPT could activate the secretion of IL-10 by CD11clowCD45RBhigh DCs, and further induce activation of immune function of T lymphocyte with shifting of Th1 to Th2 in vitro. TPT may down-regulate the immune response by promoting the phenotypic and functional maturation of CD11clowCD45RBhigh DC.