Objective To investigate the therapeutic effect of osteoporotic vertebral compression fractures treated by percutaneous kyphoplasty combined zoledronic acid.Methods Patients admitted to our hospital′s depart-ment of orthopedics from February 2010 to December 2013 were reviewed,and 67 patients underwent percutaneous ky-phoplasty were admitted.According to the application of zoledronic acid or not,they were divided into 2 groups,with 39 cases and 28 cases,respectively.On 67 patients before surgery,3 days after surgery,the end of follow -up surgery, VAS,ODI,vertebral height average recovery rate and Cobb angle were compared.The BMD was also compared before and after surgery.Results There was no difference between the two groups in all above indices before treatment(t =0.308,P =0.758;t =0.476,P =0.635;t =0.397,P =0.693;t =0.342,P =0.733).3 days after surgery,the levels of VAS,ODI and Cobb angle all decreased(t =25.820,P <0.001 vs.t =24.988,P <0.001;t =16.801,P <0.001 vs.t =17.008,P <0.001;t =9.717,P <0.001 vs.t =7.525,P <0.001),while vertebral height average recovery rate were increased in both groups(t =8.300,P <0.001 vs.t =6.363,P <0.001 ),but there was no difference between the two groups(t =0.177,P =0.861;t =0.568,P =0.572;t =0.453,P =0.652;t =0.508,P =0.613).In the end of follow -up surgery,there was a significant difference between the two groups(t =4.779,P <0.001;t =7.041,P <0.001;t =2.517,P =0.014;t =2.406,P =0.019).There was no difference between the two groups in BMD(t =0.479,P >0.05),but it came to be a difference between the two groups in the end(t =2.710,P =0.009), although there was no difference in secondary fracture(23.1% vs.7.1%,χ2 =3.016,P =0.082).Conclusion Per-cutaneous kyphoplasty combined zoledronic acid has an excellent effect on osteoporotic vertebral compression frac-tures,it is worthy promoting.

Head and neck cancer presents with complex anatomy and high intratumoralheterogeneity. Radiotherapy is one of the main treatments. The therapeutic strategy and prognostic evaluation in head and neck cancer patients traditionally depend on TNM stage, lacking of individual information. Radiomics can extracts high-throughput image features relevant to the biology of tumors, which provides a non-invasive and quantitative method to evaluate the overall tumor heterogeneity and also offers a novel perspective for precision radiotherapy. The research progresses on the application and chanllenges of radiomics in the radiotherapy for head and neck cancer were summarized in this review.

Recently the lysine succinylation was discovered in vivo, and it was demonstrated to be widely involved in cell dif-ferentiation, cell metabolism and other important physiological activities.Lysine succinylation has become the forefront of life science research.Scientists have provided a lot of evidences that proteins in prokaryotes and eukaryotes are widely succinylated, without which the central metabolism and intermediary metabolism of many metabolic enzymes are disrupted.To better understand the importance of Succinylation in vivo, protein-succinyl modification of the current research and the latest developments are reviewed, which summarize succinylated protein lysine sites in the center of important physiological metabolic pathways, diseases and other pathological conditions.

THe insulin-like growth factor(IGF) system,a very important polypeptide growth hormone,has been found to have some relation with primary adrenocortical tumorigenesis and modulates its growth.This article reviews the general biological characteristics of IGF and the relations of the IGF system with the normal adrenal cortex and primary adrenocortical tumor.It also and discuss the clinical meaning of its possible presence in the primary adrenocortical tumor.

Antimalarials ; therapeutic use ; Artemisinins ; therapeutic use ; Child ; Drug Therapy, Combination ; Humans ; Malaria, Falciparum ; drug therapy

Based on collecting data at home and abroad, we combined clinical practice of scientific researches. We also summarized key points for design and evaluation of clinical studies in treating children's attention deficit hyperactivity disorder by Chinese medical new drugs from objective and design, selection of diagnostic criteria, recruitment and dropping-out of subjects, effectiveness evaluation, safety evaluation, drug combination, and quality control, and so on. We hope to provide reference for design and evaluation of clinical studies by Chinese medical new drugs.
Attention Deficit Disorder with Hyperactivity ; drug therapy ; Biomedical Research ; Child ; Clinical Studies as Topic ; Data Collection ; Drugs, Chinese Herbal ; therapeutic use ; Humans

Breast Neoplasms ; metabolism ; pathology ; surgery ; Carcinoma, Intraductal, Noninfiltrating ; metabolism ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Mastectomy ; methods ; Neoplasm Invasiveness ; Sentinel Lymph Node Biopsy ; Survival Rate

Objective　To investigate the effect of amniotic membrane on the proliferation of YAC-1 in vitro. Methods　The YAC-1 cells were cultured with amniotic membrane and their proliferation were observed by MTT automated colorimetry on the lst day， the 3rd day and the 7th day respectively.Results　Amniotic membrane could significantly enhance the proliferation of YAC-1 on the lst day, the 3rd day and the 7th day respectively after having been seeded (P＜0.01).Conclusion　Amniotic membrane can enhance the proliferation of tumor cells (YAC-1), which should be paid attention to during amniotic membrane transplantation for treating ocular surface lesion caused by epibulbar tumors. ［Rec Adv Ophthalmol 2000;20(5)∶317-318］

Objective To investigate the effects of methylation of p73 gene on pathogenesis of acute lymphoblastic leukemia.Methods The restriction endonuclease enzyme digestion combined with PCR was used to detect p73 gene and methylation in 42 patients with acute lymphoblastic leukemia.Results Methylation of p73 gene was found in 28.6%(12/42).Patients without methylation of p73 gene had a higher complete remission rate of first chemotherapy and a longer survival time than those with methylation of p73 gene.Conclusion Methylation of p73 gene probably plays a role in the pathogenesis of acute lymphoblastic leukemia and may have clinical significance in predicting prognosis of ALL.

During the transferring period of education in military college, the teacher building was strengthened. A series of systems was established to enhance ability and passion of teaching and insure the teaching quality. The systems included the teaching certification system, the teacher training system and the evaluating system. This paper also discussed the pre-class training of teachers and human resources intercoursing between colleges and military units.