Cellular autophagy is a major degradative pathway for clearance of aggregate-prone proteins and damaged organelles. It plays an important role in regulating cellular homeostasis, cell growth and development, and disease development. Dysfunctional autophagy contributes to the pathology of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, in which specific pathological protein accumulation occurs. A growing body of evidence suggests that resveratrol plays a significantly role in the regulation of autophagy and clearance of pathological proteins. Resveratrol is a potential drug for neurodegenerative diseases therapy. This review focuses on the effects of resveratrol on cellular autophagy and clinical application in the control of neurodegenerative diseases.
Alzheimer Disease ; Autophagy ; Humans ; Huntington Disease ; Neurodegenerative Diseases ; drug therapy ; Parkinson Disease ; Stilbenes ; pharmacology

Cellular autophagy is a major degradative pathway for clearance of aggregate-prone proteins and damaged organelles. It plays an important role in regulating cellular homeostasis, cell growth and development, and disease development. Dysfunctional autophagy contributes to the pathology of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, in which specific pathological protein accumulation occurs. A growing body of evidence suggests that resveratrol plays a significantly role in the regulation of autophagy and clearance of pathological proteins. Resveratrol is a potential drug for neurodegenerative diseases therapy. This review focuses on the effects of resveratrol on cellular autophagy and clinical application in the control of neurodegenerative diseases.

Objective To evaluate the imaging features of CT and MR in patients with intraductal papillary mucinous tumor of the pancreas (IPMT).Methods Imaging findings of 10 patients with histopathologically proved IPMT were retrospectively analyzed.Of 10 cases,CT was performed in 8 patients,and MR in 6 patients.Results Eight lesions were in pancreatic head and neck,and 2 lesions were in pancreatic body and tail.The images showed the dilated pancreatic duct in all the patients,and the diameter was (0.8 ± 0.2) cm.Three patients had the dilation of branch duct,and 4 patients showed atrophy of pancreatic body and tail.The CT showed 6 cases had cystic masses with septa and mural nodules;and 2 cases had the dilation of the main pancreatic duct with intraductal mural nodules.Lesions showed low signal intensities on T1WI and high signal intensities on T2WI with septa and mural nodules,which showed moderate hypointensity on T1WI and T2WI and heterogeneous enhancement on enhanced T1WI.Conclusions There are some characteristics in CT and MR manifestation of IPMT:common in pancreatic head and neck,dilated pancreatic duct,cystic tumors with septa and mural nodules,and the enhancement of cystic wall,septa and mural nodules.The disease might be correctly diagnosed with these characteristic imaging features.

Objective To investigate the value of the combination of hs-CRP and WBC in infectious high risk infants. Methods 68 infants with infectious high risk factor were divided into high risk group,while 32 normal infants were in control group.Serum hs-CRP level and WBC were measured in the two groups. Results There were 54(79.4%)infants with serum hs-CRP level higher than 3 mg/L in high risk group,while just 8 infants in control group.Significant difference were found between the two groups(x2=27.344,P＜0.01).There were 21(30.9%)infants with WBC higher than 20 × 109/L.No significant difference was found between the two groups(P＞0.05).Serum hs-CRP and WBC were both abnormal in 21 infants with infectious experience,9 infants were diagnosed with neonatal infection. Conclusion Combination measurement of serum hs-CRP level and WBC were useful in early diagnosis of neonatal infection.

OBJECTIVE: To study the effects of total saponin of Rhizoma Dioscreae Nipponicae (TSRDN) on the expression of vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) and receptor Tie-2 in synovial tissue of collagen-induced arthritis (CIA) rats, and to investigate the antiangiogenesis mechanism of TSRDN in treating rheumatoid arthritis. METHODS: After the CIA rat model was successfully established, the rats were randomly divided into 5 groups: normal control group, CIA model group, TSRDN group, tripterygium group, and diosgenin group. Real-time PCR was used to detect VEGF mRNA expression in synovial tissue of CIA rats, and immunohistochemical staining was used to observe angiopoietin-2 and receptor Tie-2. RESULTS: VEGF mRNA, Ang-2 and Tie-2 expressions in synovial tissue of CIA rats were obviously higher than normal control group (P < 0.01). After treatment with TSRDN, tripterygium, and diosgenin, the expressions of VEGF mRNA and Ang-2 were obviously lower than those in CIA model group (P < 0.01). But Tie-2 expression showed decreasing trend, and there was no obvious differences between each treatment group. VEGF mRNA expression in TSRDN group was much lower than that in tripterygium group and diosgenin group. CONCLUSION: TSRDN can inhibit angiogenesis in synovial tissue by down regulating expressions of VEGF, Ang-2 and receptor Tie-2.

Adult ; Ear Ossicles ; injuries ; Humans ; Joint Dislocations ; Male ; Wounds and Injuries

OBJECTIVETo evaluate the impacts on the short-term efficacy and the long-term prevention of recurrence of allergic rhinitis treated with the triple-strong stimulation at Dazhui (GV 14) so as to provide the convenient and long-term effective therapy of acupuncture and moxibustion for allergic rhinitis.

METHODSOne hundred and twenty cases of allergic rhinitis were randomized into an acupuncture group, an acupuncture + medication group and a triple-strong stimulation group, 40 cases in each one. In the acupuncture group, acupuncture was applied at Dazhui (GV 14), Fengchi (GB 20), Baihui (GV 20), Yintang (GV 29) and the others, stimulating with reinforcing manipulation for the deficiency and reducing manipulation for the excess, once every day. In the acupuncture + medication group, on the basis of acupuncture therapy, claritin (loratadine tablets) was supplemented for oral administration, 10 mg, once every two days, continuously for 30 days. In the triple-strong stimulation group, on the basis of acupuncture therapy, the strong needling, strong cupping and strong moxibustion were applied at Dazhui (GV 14). This combined therapy was given once every day in the first 3 days and once every two days afterwards. The 10 day treatment made one session, at the interval of 3 days between the sessions and totally 3 sessions were required in the three groups. Separately, before treatment, after treatment and in 6 months after treatment, the changes of symptom and physical sign score and value of single item symptom including nasal itching, nasal blockage, sneezing and rhinorrhea were observed in the patients of the three groups. And the long-term clinical efficacy was compared among the three groups.

RESULTSThe symptom and physical sign score and the value of single item symptom were all reduced in the three groups after treatment and in 6 months after treatment (P < 0.001, P < 0.01, P < 0.05). The results in the triple-strong stimulation group were superior to the other two groups (all P < 0.05). In the triple-strong stimulation group, the total effective rate was 92.5% (36/40) in the follow-up of 6 months after treatment, which was better than 60.5% (23/38) in the acupuncture group and 69.2% (27/39) in the acupuncture + medication group (both P < 0.01).

CONCLUSIONThe combined therapy of acupuncture and the triple-strong stimulation at Dazhui (GV 14) achieves the reliable and effective result in the clinical treatment of allergic rhinitis and displays the good role on the prevention from long-term recurrence.

Acupuncture Points ; Acupuncture Therapy ; Adolescent ; Adult ; Child ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Moxibustion ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; therapy ; Young Adult

Humans ; Vision Disorders/etiology* ; Visual Acuity

Biofilms

Objective To compare the diagnostic value of 64-slice helical CT cholangiography and MR cholangiopancreatography (MRCP) for pancreaticobiliary obstructive diseases. Methods Thirty-six patients with pathologically proved pancreaticobiliary obstruction or endoscopic retrograde cholangiopancreatography (ERCP) were examined with MRCP and routine enhanced CT scanning. CT row data of portal venous phase were reconstructed with 0.625 mm thickness and intervals. Then multiplanar reformation (MPR) of intra- and extrahepatic biliary duct, gallbladder and pancreas was generated, and curved planar reformation (CPR) was performed when necessary. The accuracy of MPR (and CPR) and MRCP in evaluating the site and nature of obstruction was compared. Results The accuracy of MPR and MRCP was 97.22% and 94.44% in evaluating the site of obstruction, respectively. In evaluating the nature of obstruction, the accuracy of MPR and MPCP was 83.33% and 80.56%, respectively, and the accuracy of MPR increased to 88.89% in combination with CPR in some patients. There was no statistical difference between the accuracy of MPR and MRCP in evaluating the site and nature of obstruction, while their diagnostic consistency was medium (Kappa=0.471). Conclusion Both MSCT cholangiography and MRCP have high diagnostic value in pancreaticobiliary obstruction, while the former gets some advantages in images review for clinicians.