Objective To study the relationship between survival rate and pathogen,subtype,stage,delivered methods of 55 patients with severe hepatitis during late period of pregnancy.Methods Clinical data of 55 cases with severe hepatitis during late period of pregnancy was analyzed retrospectively.Results The incidence of hepatitis B was highest in patients with severe hepatitis during late period of pregnancy (84.5%).In subtypes,the incidence rates of chronic severe hepatitis,acute severe hepatitis and subacute severe hepatitis were 83.6%,5.5%,10.9% respectively(P

Objective To investigate the infection type,clinical features and prognosis in the infections complication patients with severe hepatitis.Methods 72 severe hepatitis patients with infections complication were analyzed retrospectively.Results The infection occurrence rate was 62.5% in the 72 severe hepatitis patients.Mortality rate was 75.56% in the patients with infections complication,and it was significantly higher than those without infections complication(29.63%).The mortality rate was 72.5% in the patients with multiple organ infections.The different bacterium infection could lead to different mortality rate,K.peneumoniae(69.89%),E.coli(58.12%),Staphylococcus aureaus(55.56%),Staphylococcus epidermidis(59.90%).The mortality rate was higher in the patients with lower sera albumin and higher serum bilirubin level.Conclusions The patients with severe hepatitis have bad outcome with infections complication.The prognosis is correlated with the dysfunction severity of liver and pathogenic bacteria.

The traditional medical treasures of zhouyi and qianjin have much in common in the aspects of logic approach,recognition characteristics,values conception,theory construction,and category system,which demonstrate that the two doctrines are closely related both geographically and historically. Bearing the same cultural genes and value orientation,sharing similar constructions of logic approaches and recognition characteristics,the two doctrines contain a great deal of wisdom in recognition and practice.

Objective To study the role of cyclcoxygenase-2 in the growth and development of the endome-trial lesions. Methods The expression of cycloogxygenase-2 (COX-2) were tested by immunohistocbemistry. Compar-ison of endometrial cancer COX-2 expression was made within each group at different stages,for different pathological classification. Another groups comparison of COX-2 expression was made. Results ( 1 ) COX-2 in endometrial cancer in the different expression of other differences and differences were significant ( P<0.05 ). Ⅲ mainly for the period between the stage and the other had a significant difference( P<0.05 ). (2) COX-2 in endometrial cancer,hyperplasia and normal expression of the differences between endometriosis, the difference was significant ( P<0.05 ). (3)COX-2 in endometrium cancer different pathology graduation difference:G1(high idiophase) < G2(idiophase) < G3(low id-iophase), but does not have the difference after the comparison in statistics ( P>0.05 ). (4) The expression of COX-2 in simple hyperplasia and complex hyperplasia was statistically significant different ( P<0.05 ). Conclusion That COX-2 in the development of endometrial lesions play an important role, it could be inferred of COX-2 inhibitors for endometrial cancer treatment or treatment of postoperative the timing of the loss surgery patients is feasible.

Objective To investigate the role of TRAF2 in AP-1 signaling pathway of human B cells.Methods Human Ramos B cells were transfected with plasmids expressing YFP fusion wild type TRAF2(YFP-WT-TRAF2) or YFP fusion dominant-negative TRAF2(DN-TRAF2),or transfected with shRNA-TRAF2 and control shRNA plasmid.After incubation overnight,cells were either sorted with flowcytometry or screened by antibiotics G418.Activation of AP-1 pathway,including phosphorylation of ERK,JNK and P38,as well as nuclear translocation of AP-1 subunits were detected by western blot and ELISA.Results Overexpression of WT-TRAF2 selectively induced activition of MAPK by phosphorylation of ERK and P38,and further induced nuclear translocation of C-FOS.Moreover,both overexpression of DN-TRAF2 and transfection of shRNA-TRAF2 inhibited phosphorylation of ERK and P38,and nuclear translocation of C-FOS.Conclusion TRAF2 selectively activates some kinases in CD40 mediated AP-1 signaling pathway,and plays an important role in AP-1 activation.

Adult ; Bronchoalveolar Lavage ; Humans ; Male ; Middle Aged ; Pneumoconiosis ; complications ; therapy ; Pulmonary Disease, Chronic Obstructive ; etiology ; therapy ; Treatment Outcome

Cervical Intraepithelial Neoplasia ; diagnosis ; epidemiology ; prevention & control ; virology ; China ; epidemiology ; Female ; Humans ; Mass Screening ; Nucleic Acid Hybridization ; methods ; Papillomaviridae ; isolation & purification ; Papillomavirus Infections ; diagnosis ; prevention & control ; Papillomavirus Vaccines ; Uterine Cervical Neoplasms ; diagnosis ; epidemiology ; prevention & control ; virology ; Vaginal Smears

Gastrointestinal stromal tumor(GIST) is the most common mesenchymal malignancy of the GI tract. The mainstay of treatment is surgery. For patients in whom complete resection is not possible, or in patients with metastatic or recurrent disease, they are unresponsive to standard chemotherapy and to radiotherapy. There has been no effective systemic treatment for unresectable GIST or metastatic disease. Gain-of-function mutations of the KIT proto-oncogene occur in up to 90% of GIST, allowing constitutive activation of tyrosine kinase (i.e. auto-phosphorylation of tyrosine residues independent of ligand-receptor binding), leading to aberrant cell division and tumour growth. Imatinib selectively inhibits the tyrosine kinase activity associated with KIT, which forms the rationale for evaluating its effects in GIST. Herein, we review recent developments in treatment for GIST and implication for optimal treatment in these patients.

Tumor recurrence and metastasis are the major cause for cancer patient death. Aberrant glycosylation is one of the important mechanisms of malignant tumor metastasis. The glycoprotein CD24, which could be a ligand for P-selectin on the surface of activated endothelial cells and platelets, appears to be a new diagnostic marker of tumors and possibly participates in tumor metastasis with unknown pathway. ?1,3 Fucosyltransferase Ⅶ (FucT-Ⅶ) is one of the fucosyltransferases which catalyze the transfer of a fucosyl residue from GDP-?-L-fucose to a sugar acceptor, usually galactose in the sugar chains of glycoproteins or glycolipids. The elevated expression of sialyl Lewis (SLeX), the only carbohydrate product of ?1,3 FucT-Ⅶ , predicts an ominous prognosis and high risk of recurrence and regulates the function of CD24. It is possible that ?1,3 FucT-Ⅶ may enhance the glycosylation of CD24 and thus promote the tumor metastasis.

With chinese pharmaceutical companies in the rapid development, there are many factors restricting their development, this article through consulting relevant literature, data and investing, analyzing the shortage of the pharmaceutical enterprises at the present stage in China and the factors of restricting their development, so as to put forward the solution to the current situation of pharmaceutical enterprises in China and the related measures, make more long-term and healthy development of pharmaceutical enterprises in China.