1.Study on cisplatin combination with pemetrexed disodium in the therapy for malignant pleural mesothelioma
Cancer Research and Clinic 2011;23(11):736-738
Objective To explore the clinical efficacy of ALIMTA (pemetrexed disodium) plus cisplatin.Methods Patients with malignant mesothelioma were allocated to two treatment groups envelope:pemetrexed plus cisplatin (PEM-group) or cisplatin alone (DDP-group).Results A total of 64 patients were randomly assigned and evaluated.The number of patients in PEM- and DDP-group had a significant pathologic complete response were (56.25 % vs 21.88 %,x2 =7.943,P <0.05).Progression-free survival was significantly higher in PEM-group (P <0.05),and 2-year survival rate was lower in DDP-group (P <0.05).Conclusion Pemetrexed elicit significant tumor response and delays disease progression compared with DDP alone in patients with advanced MPM.Improvement in OS is seen in this study.
2.Updates of radical antegrade modular pancreatosplenectomy applied to the surgical treatment for pancreatic carcinoma of body and tail
Chinese Journal of Digestive Surgery 2016;15(6):641-644
The traditional distal pancreatosplenectomy (DPS) has been the standard surgical procedure for the treatment of resectable pancreatic carcinoma of body and tail.With the development of medical technology,however,the results including the rate of R0 resection,number of lymph nodes dissected and postoperative 5-year survival rate were not significantly improved after DPS.According to pancreatic anatomy and phylembryogenesis,combined with renewed tumor treatment concept,the radical antegrade modular pancreatosplenectomy (RAMPS) was put forward after continuous exploration of pancreatic surgeons to improve prognosis of patients with pancreatic carcinoma of body and tail.Compared with DPS,RAMPS has advantages of R0 resection rate and regional lymphadenectomy and might become the standard surgical procedure.
3.Research on tumor suppressor mechanisms of maternally expressed gene 3
International Journal of Surgery 2016;43(7):495-498
As long non-coding RNA (LncRNA) research boom,Maternally Expressed Gene 3(MEG3) as LncRNA family is also a widespread concern.MEG3 not been studied in benign disease,and malignant disease more and more in-depth research.MEG3 because of the uniqueness of the tumor suppressor much attention in cancer research,but its specific mechanism of action of tumor suppressor and associated pathways have not been yet entirely clear,remains to be further research and clarify.This article will be now anticancer activity MEG3 and related Pathway summarized.
6.Study and biomechanical evaluation of the device of gear-distraction plate for spine reduction and fixation
Xuewen CUI ; Lianshun JIA ; Wen YUAN
Orthopedic Journal of China 2006;0(20):-
[Objective]A new device of gear-distraction plate (GDP) for spine reduction and fixation was designed and its biomechanical characteristics was evaluated.[Method]The GDP implants were made of titanium alloy (TC4,Ti6AL4V) and the instruments were made of stainless steel after design.Eighteen fresh calf lumbar specimens were randomly divided into three groups, the GDP group had a biomechanical test contrast to control group(CD, Steffee) in load-responsive change, load-displacement, strength, stiffness, torsion intensity and ultimate strength.[Result]Results It is better than control group in load-responsive change, load-displacement, strength, stiffness, torsion intensity and ultimate strength, there was a significant difference between them (P
7.Electrochemical Properties of Sodium Selenite on a Bionic Membrane of Gold Electrode Modified by L-Cysteine Self-assembled Monolayer
Jinfeng WEN ; Aihua ZHU ; Shengyun CUI
Chinese Journal of Analytical Chemistry 2009;37(12):1771-1775
The cyclic voltammetric behaviors of sodium selenite on the gold electrode modified by L-cysteine self-assembled monolayer (L-Syc,Au/SAMs) has been investigated in 0.05 mol/L H_2SO_4 solutions with sodium selenite. Sensitive anodic stripping current of selenium (Se) with the peak potential at 0.99 V (vs. SCE) has been observed. In comparison with the electrochemical properties of sodium selenite on the modified electrode with those on the naked gold electrode, it was found that selenite was reduced to selenium by the redox interaction with sulfur on the monolayer and the monolayer catalytically oxidizes Se as the electrode was positively scanned. According to the electrochemical properties of sodium selenite both on the naked and modified gold electrode, the Se deposition mechanism and catalytic mechanism as well as bionic membrane model were proposed for the bio-utilization of selenite through nano scale selenium.
8.Research about Prescription and Technology of Brucea javanica Oil Subnanoemulsion Injection
Wen PAN ; Haibo HU ; Mingchao CUI
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(01):-
Objective To optimize the prescription and technology of Brucea javanica oil subnanoemulsion injection. Methods Using superfine Brucea javanica oil as oil phase,yolk lecithin and poloxamer 188 as the complex emulsifying agents. The dosage of oil,emulsifier and stabilizer were optimized and the preparation was optimized by orthogonal experiments. Results The optimum precription was 10% oil phase,1.2% emulsifier and 0.1% stabilizer. The optimum technology was that aqueous phase and oil phase mixed at 70 ℃,sheared 20 min by high speed shearing machine and then passed the ultra-high pressure nano homogenizer 6 times under the pressure of 900 bar. Conclusion The physical stability of Brucea javanica oil subnanoemulsion injection is good.
9.Impact of Myocardial Infarction and Abnormalities of Cardiac Conduction System on Sudden Cardiac Death
Ruying SONG ; Runtao DING ; Wen CUI
Journal of Forensic Medicine 2017;33(2):171-174
Sudden cardiac death (SC D ),m ostcom m only seen in coronary heart disease, is a kind of sud-den death caused by series of cardiac param eters, w hich usually com bines w ith m yocardial infarction. H ow ever, som e SC D s (including early m yocardial infarction) happen suddenly and cause death in a very short tim e. In these circum stances, typical m orphological changes are lack in m acroscopic or m icroscopic fields, w hich m ake such SC D s becom e the em phasis and difficulty in the present research. SC D caused by m yocardial infarction and abnorm alities of cardiac conduction system (C C S ) is related to atheroscle-rosis of coronary artery closely. T his paper review s cardiac dysfunction caused by m yocardial infarction and diseases of C C S from m orphology and m olecular biology, and explores potential relationship be-tw een them . T his paper aim s to provide clues to the m echanism of m yocardial infarction related sudden death and possible assistance for forensic diagnosis of SC D .
10.Experimental study of mouse cytomegalovirus infected mice.
Wen, CUI ; Yongsui, DONG ; Feng, FANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2002;22(3):260-4
In order to investigate the human cytomegalovirus (HCMV) infection, the mouse cytomegalovirus (MCMV) infected mice were experimentally studied. 6 to 8 week old female BALB/C mice with immunosuppression were selected to undergo the MCMV inoculations: intracranial inoculation and peritoneal inoculation. MCMV of the infected mice in various organs and tissues were detected by using beta-gal staining and in situ nucleic acid hybridization assay. The pathological changes were observed in HE staining paraffin-embedded sections. It was found that all the MCMV infected mice showed the retardation of growth and development, and feather looseness. Both intracranial inoculation of 10(4) PFU viruses or peritoneal inoculation of 10(6) PFU viruses resulted in the pathological changes, to some extent, of various organs and tissues in the mice. The pathological changes in liver were consistent with the amount of beta-gal staining positive cells, indicating the liver lesions were mainly caused by viral proliferation. It was also found that the viruses in the immunosuppressed mice subjected to intracranial inoculation could spread to whole body organs, while the viruses in the immunosuppressed mice subjected to intrapeitoneal inoculation couldn't spread to the brain, suggesting blood-brain barrier could prevent the virus from spreading to the brain.
Blood-Brain Barrier
;
Brain/pathology
;
Brain/virology
;
Disease Models, Animal
;
*Herpesviridae Infections/pathology
;
*Herpesviridae Infections/virology
;
Immunocompromised Host
;
Liver/pathology
;
Liver/virology
;
Lung/pathology
;
Lung/virology
;
Mice, Inbred BALB C
;
*Muromegalovirus