1.SYNTHESIS AND ACTIVITIES OF 4-DEOXY-4β-ARYLMEHTYLENE SULFONYLAMIDO-4′-DEMETHYLPODOPHYLLOTOXINS
Yong HE ; Weiyong MA ; Xiuhua CHEN ; Chunnian ZHANG
Acta Pharmaceutica Sinica 2001;36(2):105-107
AIM To find new anticancer drug based on the structure of podophyllotoxin. METHODS AND RESULTS 4-Deoxy-4β-arylmethylenesulfonylamido-4′-demethylpodophyllotoxins were (1-15) synthesized and their antitumour activities against KB cells and L1210 leukemia cells were tested. CONCLUSION These compounds are new compounds. Among them, compounds 2, 3, 8, 9, 11 and 12 showed antitumour activities. When halides exist on the aryl ring of substituted sulfonyl group, the corresponding compound has relatively higher activities. The stereo factor is important for the activities.
2.Comprehensive Evaluation on Pilot's Situation Cognition
Wei LIU ; Xiugan YUAN ; Lijuan LV ; Zhongqi LIU ; Weiyong KANG ; Rui MA
Space Medicine & Medical Engineering 2008;21(5):377-381
Objective To resolve the problems of comprehensive evaluation on pilot's situation cognition basing on studying the mission situation. Methods The model of fuzzy comprehensive evaluation on pilots' situation cognitive was established on the basis of researches on concepts and methods of environmental quality evaluation in environment science.Results On the basis of theoretical consideration and analysis of experiments, the state of pilot's situation cognition was revealed preliminarily.Conclusion It is showed that the fuzzy comprehensive evaluation method on pilot's situation cognition can provide real and complete flight cognitive information. It is reliable basis for pilot's efficacy of training and flight safety.
3.Factors affecting HIV testing among male college students with sexual behaviors
Hui WANG ; Xiaohong PAN ; Qiaoqin MA ; Weiyong CHEN ; Lin HE ; Jinlei ZHENG ; Wanjun CHEN ; Tingting JIANG
Journal of Preventive Medicine 2022;34(11):1081-1085
Objective:
To investigate the factors affecting HIV testing among male college students with sexual behaviors, so as to provide the evidence for improving the detection of HIV testing among young college students.
Methods:
Four undergraduate universities and one junior college were randomly sampled from Hangzhou City using a purposive sampling method during the period between September and November, 2021, and male students with self-reported sexual behaviors were recruited as study students. Participants' demographics, AIDS-related knowledge, sexual behaviors and HIV testing were collected using questionnaires, and factors affecting HIV testing using a multivariable logistic regression model.
Results:
A total of 720 male college students with sexual behaviors were enrolled, including 180 freshmen (25.00%), 178 sophomores (24.72%), 163 juniors (22.64%), 50 seniors (6.94%) and 149 postgraduates (20.69%), and 94 students received HIV testing (13.06%), including 57.45% receiving self-testing. Multivariable logistic regression analysis identified postgraduates (OR=0.302, 95%CI: 0.127-0.719), sexual orientation (homosexual, OR=0.090, 95%CI: 0.028-0.294; bisexual/uncertain, OR=0.181, 95%CI: 0.066-0.495), awareness of HIV testing (low awareness, OR=0.411, 95%CI: 0.176-0.957; moderate awareness, OR=0.305, 95%CI: 0.123-0.757; high awareness, OR=0.087, 95%CI: 0.032-0.235) as factors affecting HIV testing among male college students with sexual behaviors.
Conclusions
The prevalence of HIV testing correlates with awareness of HIV testing among male college students with sexual behaviors. Improvements in health education of HIV testing and accessibility of HIV testing services are recommended.
4.Factors affecting multiple sexual partner behaviors among men who have sex with men at ages of 16 to 24 years in Zhejiang Province
Tingting JIANG ; Qiaoqin MA ; Lin CHEN ; Lin HE ; Wanjun CHEN ; Weiyong CHEN ; Hui WANG ; Jinlei ZHENG
Journal of Preventive Medicine 2022;34(11):1091-1095
Objective :
To investigate the factors affecting multiple sexual partner behaviors among men who have sex with men (MSM) at ages of 16 to 24 years in Zhejiang Province, so as to provide the evidence for formulating the integrated interventions for HIV/AIDS among adolescents.
Methods :
The demographic features, sexual behaviors and HIV testing were collected from MSM at ages of 16 to 24 years in Zhejiang Province through the Management Information System of China AIDS Fund for Non-governmental Organizations (CAFNGO) in 2021. The factors affecting multiple sexual partner behaviors were identified among MSM at ages of 16 to 24 years using a multivariable logistic regression model.
Results :
A total of 1 253 participants were enrolled, with a mean age of (21.16±2.06) years. There were 1 219 unmarried respondents (97.29%), 807 (64.61%) with diploma and above, 250 (19.95%) with multiple sexual partners during the past 3 months, 344 (27.45%) with unprotected sexual behaviors in the past 3 months, 71 (5.67%) that had used rush or new drugs, 511 (40.78%) that were unaware of their sexual partners' HIV infections, 28 (2.23%) with symptoms or diagnosis of sexually transmitted diseases, and 35 (2.79%) with positive HIV testing. Multivariable logistic regression analysis identified age (19 years-, OR=2.563, 95%CI: 1.404-4.679; 22 to 24 years, OR=2.149, 95%CI: 1.180-3.913), having unprotected sexual behaviors in the past 3 months (OR=5.338, 95%CI: 3.938-7.237), having used rush or new drugs in the past 3 months (OR=3.669, 95%CI: 2.142-6.286), unaware of sexual partners' HIV infections(OR=1.402, 95%CI: 1.032-1.903), and positive HIV tests (OR=2.763, 95%CI: 1.298-5.880) as factors affecting multiple sexual behaviors among MSM at ages of 16 to 24 years.
Conclusions
The multiple sexual behaviors correlate with age, unprotected sexual behaviors, use of rush or new drugs and unawareness of sexual partners' HIV infections among MSM at ages of 16 to 24 years.
5.SWOT analysis of HIV control strategy in key areas of Zhejiang Province
CHEN Weiyong ; MA Qiaoqin ; CHENG Wei ; JIANG Jun ; HE Lin ; ZHENG Jinlei ; ZHOU Xin ; CHEN Lin ; CHAI Chengliang
Journal of Preventive Medicine 2022;34(1):78-82
Objective :
To analyze the problems in the AIDS control strategy in key areas of Zhejiang Province, so as to provide insights into the improvement of the control strategy.
Methods :
The AIDS control data were collected from 10 key counties (districts) in Zhejiang Province, and the AIDS control strategy was comprehensively evaluated using a SWOT analysis.
Results :
The strengths of the AIDS control strategy in key counties (districts) of Zhejiang Province included distinct working objectives, well-organized leadership, and effective control measures, the weaknesses included large number of HIV-infected cases, high burden of disease, difficulty in management of AIDS transmission and insufficient AIDS control capability, and the opportunities included the AIDS control in key counties (districts) conforming to the current status of AIDS control, strong support of innovative strategies and technical support from professional teams, while the threats included insufficient working mechanisms for AIDS control, the gap between the effectiveness of AIDS control and the target goal and unverified scientific evidence of the control strategy. Supported policies should be fully used, working mechanisms need to be improved, control strategies need to be innovated, and assessments need to be implemented for AIDS control in key counties (districts).
Conclusions
There are both opportunities and challenges for AIDS control in key counties (districts) of Zhejiang Province. Optimization of the working mechanisms, promotion of precision interventions, and search for repeatable control strategy in other disease-affected regions are required for AIDS control.
6.Characteristics of male college students with temporary heterosexual behaviors through Internet dating
Wanjun CHEN ; Lin CHEN ; Hui WANG ; Lin HE ; Weiyong CHEN ; Tingting JIANG ; Jinlei ZHENG ; Xiaohong PAN ; Qiaoqin MA
Journal of Preventive Medicine 2022;34(11):1086-1090
Objective:
To investigate the characteristics of temporary heterosexual behaviors among male college students through Internet dating, so as to provide insights into HIV/AIDS control among young college students.
Methods:
A total of 15 universities/colleges were sampled from Zhejiang Province using a stratified cluster sampling method, and 3 schools/departments were sampled from each university/college. Male college students with temporary heterosexual behaviors during the past year were recruited. Participants' demographics, AIDS-related knowledge, compliance to HIV/AIDS interventions, Internet dating and sexual behaviors were collected, and the characteristics of male college students with Internet dating were analyzed.
Results :
A total of 326 students were enrolled, including 202 participants from regular institutions of higher education (61.96%) and 124 students from higher vocational colleges (38.04%). There were 79 freshmen (24.23%), 99 sophomores (30.37%), 104 juniors (31.90%) and 44 seniors (13.50%), and there were 100 participants (30.67%) with temporary heterosexual behaviors through Internet dating during the past year. Among the 100 participants, there were 75.00% of participants knowing “man who have sex with man is the main transmission pattern of AIDS among young students in China”, 93.00% knowing “insisting on accurate use of condoms may reduce the risk of HIV infections and transmission” and 93.00% knowing “seeking HIV testing and counseling actively following high-risk behaviors”. There were 77 participants (77.00%) with students as their temporary heterosexual partners, 17 participants (17.00%) that had received HIV self-testing and 17 participants (17.00%) that had received HIV testing in medical institutions, 22 participants (22.00%) that had never used condoms during temporary heterosexual behaviors during the past year, and 29 participants (29.00%) with commercial sexual behaviors during the past year. In addition, male college students with temporary heterosexual behaviors through Internet dating were more unlikely to use condoms and more likely to have commercial sexual behaviors than those with dating through other ways (P<0.05).
Conclusions
Male college students with temporary heterosexual behaviors through Internet dating are more likely to have high-risk sexual behaviors than those with dating through other ways. Internet-based mobile sexual education and HIV/AIDS health education are recommended.
7. Analysis of oral sexual behavior and related factors among male students from college graduation in Hangzhou
Weiyong CHEN ; Xiaohong PAN ; Zhihong GUO ; Xin ZHOU ; Hui WANG ; Qiaoqin MA
Chinese Journal of Preventive Medicine 2019;53(3):289-292
Objective:
To study oral sexual behavior and related factors among male students.
Methods:
The male students from college graduation in Hangzhou were selected as the study objects, and the inclusion criteria were having had sex and informed the type of behavior. A total of 490 subjects were finally included.
Results:
Among 490 male students, the 20-22 years old, 23 years old and 24-27 years old age groups accounted for 38.8% (
8.Assessment on the third round of Zhejiang Comprehensive AIDS Response program
CHEN Weiyong ; PAN Xiaohong ; YANG Jiezhe ; JIANG Jun ; JIANG Tingting ; CHEN Lin ; CHEN Wanjun ; WANG Hui ; ZHOU Xin ; MA Qiaoqi
Journal of Preventive Medicine 2020;32(3):240-244
Objective:
To evaluate the third round of Zhejiang Comprehensive AIDS Response (CARES) program (nine national areas and three provincial areas) and the control effect of AIDS, so as to provide reference for AIDS prevention and control.
Methods:
According to the final assessment protocol of the third round of China CARES, the data of 23 assessment items which were collected from online database and field investigation for 12 response areas of Zhejiang in 2014 and 2018 were evaluated. The endemic situation and detection of AIDS in CARES areas was compared with those in non-CARES areas, in order to evaluate the achievement of Zhejiang CARES areas.
Results:
The rates of reaching the standard ranged from 91.30% to 100.00% in 12 CARES areas. Six indexes in leadership and innovation, fifteen (seventeen in total) indexes in HIV/AIDS control and prevention reached the standard. The items that failed included the awareness rates of AIDS and indicators in “prevention and intervention”. The rates of of reaching the standard in “publicity and education”, “monitoring and testing”, “prevention and intervention”, and “treatment and follow-up” increased from 55.56%, 79.17%, 79.76% and 65.00% in 2014 to 91.67%, 100.00%, 90.48% and 100.00% in 2018, respectively. The proportion of HIV testing people in permanent residents was 30.94% in CARES areas in 2018, which was significantly higher than 20.70% in non-CARES areas (P<0.05). The proportion of new reported HIV/AIDS in CARES areas was 50.87%, and the average increase was 4.48%, which was lower than 9.95% in non-CARES areas.
Conclusion
The third round of Zhejiang CARES program has remarkable achievement and plays a positive role in the prevention and control of AIDS.
9. Evaluation on the confidence of refusing unprotected sex behavior and related factors among college students in Zhejiang province
Tingting JIANG ; Lin CHEN ; Xin ZHOU ; Hui WANG ; Wanjun CHEN ; Weiyong CHEN ; Xia WU ; Luobin JIN ; Hongwei ZHU ; Qiaoqin MA
Chinese Journal of Epidemiology 2019;40(12):1601-1605
Objective:
To understand the confidence-related factors of refusing unprotected sex behavior among college students in Zhejiang province.
Methods:
Stratified cluster random sampling method was conducted among college students from 13 colleges and universities in Zhejiang province, from October to November, 2018. A total of 3 718 students who self-reported "ever having had sexual contacts" were enrolled. Chi-square test was used to compare the confidence of rejecting unprotected sex under different demographic characteristics, sexual attitude/behaviors and different intervention approaches. Multivariate logistic regression model was used to analyze the related factors.
Results:
A total of 3 718 college students were involved in this study with average age as (20.17±1.38) years old and 70.5
10.Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques.
Dali TONG ; Mei ZHANG ; Yunru YANG ; Han XIA ; Haiyang TONG ; Huajun ZHANG ; Weihong ZENG ; Muziying LIU ; Yan WU ; Huan MA ; Xue HU ; Weiyong LIU ; Yuan CAI ; Yanfeng YAO ; Yichuan YAO ; Kunpeng LIU ; Shifang SHAN ; Yajuan LI ; Ge GAO ; Weiwei GUO ; Yun PENG ; Shaohong CHEN ; Juhong RAO ; Jiaxuan ZHAO ; Juan MIN ; Qingjun ZHU ; Yanmin ZHENG ; Lianxin LIU ; Chao SHAN ; Kai ZHONG ; Zilong QIU ; Tengchuan JIN ; Sandra CHIU ; Zhiming YUAN ; Tian XUE
Protein & Cell 2023;14(1):69-73