Arsenic exposure can cause health problems to our body but arsenic can also be used to treat some diseases through induction of cell apoptosis.These effects are due to arsenic toxicity,but the mechanism is still unclear.Recent studies have showed that cell apoptosis induced by endoplasmic reticulum stress is associated with the mechanism.Therefore,in this paper,the role of endoplasmic reticulum stress in arsenic toxicity has been reviewed and some problems in current studies are pointed out,so as to provide clues and basis for further scientific research.

Objective To establish the optimum preparation process for Yinxingye Dropping Pills. Methods The preparation conditions, such as different kinds of primary substance, cooling agent, the proportion between the extracts and primary substance, etc, were studied with L9 (34) orthogonal design. Results At the following conditions could the best was 30 d/min, dropping distance was 8cm, and cooling temperature was 10℃. Conclusion This preparation process was suitable for both laboratory test and industrial production for Yinxingye Dropping Pills.

Objective To establish the optimal extraction technology for Yishen Jiangu Granules.Methods The orthogonal test was employed for selecting the optimum of extraction technology. The investigation factors were the consumption of water, the times and time of extraction. The extraction technology of Yishen Jiangu Granules was screened by the transfer rate of icariin in herb epimedii and yield of extraction.Results The best extraction condition was as follows:10 times of water, extracted for 3 times , each time was 3 h,2 h and 2 h. Conclusion This extracting technology for Yishen Jiangu Granule was objective, feasible, stable,reasonable and with good reproducibility.

OBJECTIVE:To observe the therapeutic effect of IF ?-2b plus compound glycyrrhizin on chronic hepatitis C. METHODS:56cases of chronic hepatitis C were divided into trial group(30cases)and control group(26cases).Trial group received IF ?-2b +compound glycyrrhizin and control group received IF ?-2b alone.The therapeutic course was24weeks in both groups.RESULTS:There was significant difference in recoversion rate of ALT between two groups either at the end of ther?apeutic course or24weeks after treatment(P

OBJECTIVE:To put forward constructive suggestions about human resource management in Chinese pharma?ceutical enterprises in new century.METHODS:Based on relevant literature,the current situation of human resource manage?ment in state-own pharmaceutical enterprises was surveyed and analysed.RESULTS&CONCLUSION:Only by raising the level of human resource management and practicing new management modes,the pharmaceutical enterprises will get sustained benefit of the company and society.

Objective To study the half quantitative diagnostic method of the high-risk gastrointestinal stromal tumors (GISTs) with analyzing the characteristic of high-risk and lower risk GISTs with multi-slice spiral CT (MSCT). Methods CT findings of 46 patients with 51 GIST lesions were retrospectively analyzed. The location, size, shape, boundary, growth pattern and other specialties of the tumors in high-risk and lower risk GISTs were studied, moreover statistical analysis was conducted, logistic regression equation was obtained. Results Significant difference was found in tumors' location, size, shape, boundary and distant metastasis between the two types of GISTs. There were obvious correlation between the risk level and tumors' size and boundary which could be used to build the diagnostic equation of high-risk GISTs. Conclusion The equation ln [P/(1-P)]=-2.612X_3+0.371X_5 (X_3:tumors' boundary, X_5:tumors' size) is valuable in the diagnosis of high-risk GISTs.

Objective To evaluate the value of spiral CT in diagnosis and treatment of lung lesions in clini-cal work.Methods A retrospective analysis of 100 patients with pathological diagnosis of lung lesions patients were randomly divided into the control group (CT normal scan)and observation group (CT -D post -processing tech-niques).Lungs lesions,hilar and mediastinal lymph node metastasis sensitivity,specificity and accuracy of lymph node metastasis of both group were analyzed.Results In the control group,the diagnosis of lung lesions showed sensitivity of 75%,specificity of 50% and accuracy of 72%;while in the observation group the sensitivity was 80%,specificity was 65 % and accuracy rate was 85%.The differences between the two groups were statistically signficant(χ2 =3.854,4.604,5.007,all P <0.05).50 cases of pathologically verified as lung cancer patients with hilar lymph node metastasis in the control group showed diagnostic sensitivity of 60%,specificity of 72%,accuracy of 70%;while diag-nosed hilar lymph node metastasis in the observation group showed sensitivity of 76%,specificity of 84 percent and accuracy rate of 84%.The differences between the two groups were statistically signficant(χ2 =5.882,4.196,5.534, all P <0.05).50 cases of pathologically verified as lung cancer patients with mediastinal lymph node metastasis in the control group,showed diagnostic sensitivity of 62%,specificity of 57% and accuracy of 60%;in observation group the sensitivity was 72%,specificity was73% and accuracy was 72%.The differences between the two groups were statisti-cally signficant(χ2 =4.342,5.626,4.583,all P <0.05).Conclusion The spiral CT for diagnosis of lung lesions positioning has good effect,and can be widely used in the diagnosis of lung lesions.

Infection is one of the most serious diseases during the neonatal period and the leading cause of neonatal death.Early virus detection is particularly important in the vulnerable infants hospitalized in modern, family centered NICUs.These units bear increasing risks of virus transmission as they provide kangaroo care, 24 hour visiting policies, and are not only open to parents and siblings, but do also encourage their involvement.Due to the atypical clinical features, susceptibility to mixed viral-bacterial infection, lower positive rate of detection, non-specific treatment options, and causing short-term as well as long-term complications or even death if the infection is severe.Thus, it is very important to recognize respiratory virus infection early to prevent and control its spread in neonatal wards.This article aimed to elaborate the susceptibility factors, common pathogens, detection methods and the management of prevention, and control of neonatal respiratory virus infection.

Objective To investigate the curative effect of bicyclol in treatment of chronic type B hepatitis.Methods 60 cases of chronic type B hepatitis were treated with bicyclol and the changes of hepatic function,HBV-DNA and antigen-antibody of HBV were investigated between pretherapy and post-treatment.Results The ALT and AST decreased obviously after treatment of bicyclol for 3 months,there was significant difference compared with pretherapy(49.30?28.30) vs (139.05?37.31),P

OBJECTIVE:To observe the curative efficacy of compound glycyrrhizin in the treatment of chronic type B hepatitis.METHODS:102patients with type B hepatitis were randomly selected to receive compound glycyrrhizin60ml by in-travenous drip infusion once daily for30days.The clinical symptoms,signs,and indexes of hepatic function and hepatic fibrosis were observed before and after treatment.RESULTS:As compared with treatment before,patients’symptoms,signs,indexes of hepatic function and hepatic fibrosis all had obvious amelioration after treatment(P