As an immune regulator, vitamin D plays a role in asthma. In the fetus, vitamin D participates in immune system and lung development. It has been reported that vitamin D deficiency may explain a portion of the asthma epidemic. Beneficial associations have been reported between vitamin D and asthma severity in children. Epidemiologic studies have also suggested that higher prenatal vitamin D intakes have a protective role against wheezing illnesses in young children. In addition, vitamin D may play a therapeutic role in steroid resistant asthmatics and there is interest in using vitamin D therapeutic-ally to complement conventional asthma therapy, such as specific immunotherapy.

This paper introduces the viewpointins from recent researches about carbohydrate ingestion and mobilization and oxidation of fat during exercise in sports nutrition and interactional influence of carbohydrate and fat metabolism during exercise. Keywords：exercise;carbohydrate;fat;metabolism

This article discussed the author applied the thought of treatment based on syndrome differentiation that acquisitioned from following the master for many years.The three cases of experience in treating insomnia,welling-abscess of the lung and minor chest bind disease applying classical formulae of Xiaochaihu decoction,Weijing decoction and Xiaoxianxiong decoction separately all get preferable clinical curative effect.

Objective To investigate the effects of lidocaine and methylene blue on the analgesia of the anal pain after hemorrhoids. Methods Using computer random way, to the hospital from January 2014 to October 2016 postoperative anal pain patients, 52 cases of hemorrhoids were randomLy divided into normal group and research group, 26 cases of each item, which the conventional pain processing, conventional group team to lidocaine and methylene blue, compared two groups of patients with analgesic effect and the incidence of adverse reactions. Results 1d, 3d, 5d and 7d were performed after surgery, and the VAS pain score of the study group was lower than that in the conventional group, and the results of the test were statistically significant (P<0.05). Statistical incidence of adverse reactions in both groups, found the team vomiting nausea, headache, dizziness and transient hypertension incidence of adverse reactions, significantly lower than the normal group, the difference between groups with the clinical inspection was statistically significant (P<0.05). Conclusion The postoperative anal pain, hemorrhoids application of lidocaine and methylene blue, can obtain satisfactory analgesia effect, operation method is simple, low incidence of adverse reactions, safe and reliable, and can use it as a clinical analgesic solution recommended applications.

Aiming at the characteristics of Chinese medical university,the paper discusses the teaching model of mathematics,including the setup as well as content of curriculum,course examination and teaching method.Under the new teaching pattern,the students not only have a good command of mathematics but also develop the ability of knowledge application.

ObjectiveObserving the distribution and the change of the quantity of SP,VIP in the colon tissue of 'cathartic colon'rats.MethodsWe divided the 32 wistar rats weighted (200 ±10)g into 2 groops randomly:the blank group( n =8) and model group( n =8).we induced the 'cathartic colon'rats with the suspension of dahuang.The blank group were given the distilled water for contrast.After one week during the time Dahuang was stopped.We killed them,measured the carbon powder propulsion rates in the intestine and then took Specimen after the 8 rats were fasted 24 hours as well as the blank group,but water were given.We compared the variation of SP,VIP distribution between two groups.ResultsThe carbon powder propulsion rates in the model group were slower than that in the saline control group.The distribution of SP,VIP are all more than that in the blank group.ConclusionThe distribution of SP,VIP are all more than that in the blank group.

Survivin is an apoptosis inhibitor and plays an important role in the development and progression of cancer.It is undetectable in normal adult tissues,but has been showed to be overexpressed in various cancers and has been regarded as a marker of malignancy.And the promoter polymorphism of Survivin gene is closely related to risk of cancer and gene susceptibility,this might provide clues for further elucidation of the correlation of risk of cancer and genetic polymorphism,and for diagnosis,prevention and screening of cancer gene.

Objective To observe the effect of rosiglitazone combined with ethinylestradiol cyproterone on treatment of polycystic ovary syndrome (PCOS).Methods Sixty-eight cases with PCOS combined with insulin resistance (experimental group) and 68 cases with PCOS combined without insulin resistance (control group) were selected.The patients in experimental group were given rosiglihtazone combined with ethinylestradiol cyproterone,the patients in control group were not given rosiglitazone.The level of seurm adiponectin and lepfin was measured before and after treatment in two groups,body mass index (BMI),Homeostasis model assessment of insulin resistance index (HOMA-IR) was calculated before and after treatment in two groups,and drug adverse reaction was observed.Results There was no significant difference in serum adiponeetin,leptin,BMI before treatment between two groups (P ＞ 0.05).HOMA-IR in experimental group was higher than that in control group (3.90 ± 0.87 vs.2.15 ± 0.62),and there was significant difference (P ＜ 0.05).BMI,leptin after treatment in experimental group and control group was decreased compared with that before treatment [experimental group:(25.41 ± 1.01) kg/m2 vs.(30.11 ± 1.51) kg/m2,(0.25 ± 0.08) μ g/L vs.(0.44 ± 0.11) p g/L; control group:(26.68 ± 1.12) kg/m2 vs.(30.55 ± 1.42) kg/m2,(0.23 ± 0.1 0) μ g/L vs.(0.39 ± 0.23) μ g/L],adponectin was increased compared with that before treatment [experimental group:(1.39 ± 1.10) μ g/L vs.(0.89 ± 0.15) μ g/L;control group:(1.42 ± 1.05) μ g/L vs.(0.91 ± 0.44) μ g/L],and HOMA-IR after treatment (2.09 ± 0.68) in experimental group was lower than that before treatment,and there was significant difference (P ＜ 0.05).There was no significant difference between two groups (P ＞0.05).Experimental group did not appear obvious drug adverse reaction in the process of treatment.Conclusion Ethinylestradiol cyproterone can improve metabolic disorders indicators,PCOS combined with insulin resistance should add rosiglitazone to improve insulin resistance.

The ketogenic diet has been used for the treatment of epilepsy for 90 years, it also has been introduced to our country for more than 10 years.Its clinical efficacy has been recognized,but its antiepilepsy mechanisms are still unclear.This paper reviews its possible antiepilepsy mechanisms from the ion channels, neurotransmitters, neuroprotection, adenosine, mTOR signaling pathway and immune factors.

Objective To observe the treatment effect of cetylpyridinium chloride gargle on the oral candidi-asis infection.Methods According to the selection of different drugs,88 cases with candidiasis infection were divided into the cetylpyridinium chloride gargle treatment group and the compound chlorhexidine gargle control (control group),44 cases in each group.The oral pain improvement,oral mucosal atrophy,swollen gums bleeding,microscopy positive rate,colony number and patients with oral erythema score,clinical efficacy and adverse reactions were observed and compared in the two groups.Results The total effective rate of the treatment group was 95.5%,which was significantly higher than 77.3% in the control group(χ2 =8.063,P =0.019),and the difference was statistically significant.After treatment,mucosal atrophy and erythema scores of the treatment group were significantly better than control group,and there were statistically significant differences (t =6.142,P =0.033;t =6.554,P =0.044).After treatment,the number of colonies and microscopic examination positive rate of the treatment group were better than those of the control group,and with statistical significance (χ2 =11.596,P =0.019;χ2 =6.994,P =0.031 ). Conclusion Cetylpyridinium chloride gargle in the treatment of oral candidiasis infection disease not only has signifi-cant effect and can effectively reduce the pain of patients with oral,reduce the incidence of adverse reaction,it is safe and reliable,it is worth popularization and application in oral candidiasis.