Objective To evaluate the clinical value of combined treatment for spontaneous intraventricular hemorrhage. Methods 26 patients with spontaneous intraventricular hemorrhage were conducted on the whole turn of low lateral drainage of bilateral urokinase infusion therapy, supplemented by lumbar puncture cerebrospinal fluid replacement. Results The total effective rate was 84.62% ,mortality rate was 15. 38%. Conclusion Bilateral lateral drainage of alternating low urokinase infusion,supplemented by lumbar puncture cerebrospinal fluid replacement was effective in treatment of spontaneous intraventricular hemorrhage. It could reduce mortality in patients with intraventricular hemorrhage and increase the patients' prognosis.

Objective To investigate the potential mechanism of Jianpi Shenshi Formula for the treatment of hyperuricemia(HUA)by using network pharmacology and molecular docking techniques.Methods The active ingredients of Jianpi Shenshi Formula were searched and screened by combining TCMSP,BATMAN,and TCM-ID database with literature,and then SwissTargetPrediction was used to obtain the corresponding targets of the ingredients.Cytoscape 3.8.0 was used to construct a"drug-ingredients"network to analyze and obtain the main active ingredients of Jianpi Shenshi Formula.The GeneCards,OMIM,and disgenet databases were used to obtain the relevant targets of hyperuricemia.The intersection targets of Jianpi Shenshi Formula and hyperuricemia were imported into the STRING database for protein-protein interaction(PPI)network analysis,and hub targets for network were screened by CytoHubba plug-in.Meanwhile,the GO function and KEGG pathway enrichment analysis of the intersection targets were carried out using R4.2.2 software.Molecular docking of hub targets and key ingredients was performed using CB-DOCK 2.Results A total of 90 active ingredients of Jianpi Shenshi Formula were screened,among which quercetin,kaempferol,luteolin,stigmasterol,and ethyl linoleate were the main active ingredients,and 837 targets corresponding to the ingredients were obtained,with a total of 64 intersecting targets.CASP3,IL1B,IL6,PPARG,SIRT1,MAPK3,TNF,STAT3,TGFβ1,PTGS2,and XDH were the hub targets.The potential targets of action are mainly enriched in signaling pathways such as inflammation,metabolism,environment,cellular processes,biological systems,and hyperuricemia-related pathways.Conclusion Jianpi Shenshi Formula may exert effects on inhibition of uric acid production,and/or enhancement of uric acid excretion,anti-inflammation,and amelioration of related complications through the modulation of hyperuricemia-related signaling pathways(including neoplastic,infectious,metabolic,and cardiovascular diseases),as well as metabolic,immune,inflammatory,and other biological pathways by a variety of active ingredients such as quercetin,kaempferol,luteolin,stigmasterol,and ethyl linoleate.

OBJECTIVE: To investigate the body sweat,urine excretion and water intake of iron and steel production workers working under high temperature.METHODS: Two hundred and twenty-six workers working under high-temperature were selected as high-temperature group and 39 non-high-temperature workers as control group from an iron and steel production enterprise of Tangshan City by cluster sampling method.The workers working under high-temperature were divided into 4 subgroups(moderate physical labor 30-34 ℃ subgroup Ⅰ,heavy physical labor 30-34 ℃ subgroup Ⅱ,35-39 ℃subgroup and 40-43 ℃ subgroup) according to the labor intensity and the exposure temperature.The wet bulb globe temperature(WBGT) index in workplace was determined.The water intake survey was carried out.Water loss was estimated by body mass difference.The unit of body mass difference before and after work was conversed from kg into mL with formula“1 kg = 1 000 mL”.RESULTS: The water intake was 1 200-4 102(2 456 ± 612) mL in workers working under high-temperature,the drinking amount accounting for 74.5%-80.0% in the total water intake which were 2 004-5 749(3 810 ±672) mL.The difference of body mass before and after work was 1 513-4 932(3 078 ± 662) mL in the hightemperature operation group.The sweat excretion accounted for 86.5% of the total water excretion.In moderate physical labor 30-34 ℃ subgroup I,the total water intake,the body mass difference before and after work,the sweat and the total fluid excretion were higher and the urine excretion was lower than those of control group(P<0.05).The total water intake,the body mass difference before and after work,the sweat and the total fluid excretion in body of heavy physical labor 30-34 ℃ subgroup Ⅱ were higher than those of moderate physical labor 30-34 ℃ subgroup Ⅰ(P<0.05).With the increase of WBGT index,the total water intake,the body mass difference before and after work,the sweat and the total fluid excretion in body of 3 heavy physical labor subgroups increased and their urine excretion decreased which showed a dose-effect relationship(P<0.05).The D-value between the water intake and the sweat excretion of high-temperature operation group workers were-769--322 mL,those between the total water intake and losses were-598--96 mL.CONCLUSION: The fluid intake and excretion in workers working under high-temperature in iron and steel plant are in a negative balance.The water intake is lower than the recommended drinking amount under high-temperature environment.Sweating is the main way of water loss under high-temperature working condition.