1.Clinical Observation of Acupuncture plus Auricular Point Sticking for Polycystic Ovary Syndrome
Qianqian LI ; Weiquan ZHONG ; Jian ZHANG ; Rongyan ZENG ; Shulan FENG
Shanghai Journal of Acupuncture and Moxibustion 2017;36(8):895-899
Objective To observe the clinical efficacy of acupuncture plus auricular point sticking in treating polycystic ovary syndrome (PCOS). Method A total of 80 PCOS patients were randomly divided into a treatment group of 40 cases and a control group of 40 cases. The treatment group was intervened by acupuncture plus auricular point sticking, while the control group was intervened by acupuncture only. The clinical efficacy was observed in the two groups after 3 treatment courses. Result The menstrual condition and basal body temperature (BBT) were compared in the two groups before and after the treatment. The menstrual condition and BBT in the treatment group were significantly improved (P<0.01); the menstrual condition was improved (P<0.05) and the BBT condition was significantly improved in the control group (P<0.01). The total effective rate was 82.5% in the treatment group, significantly different from that in the control group (P<0.05). Conclusion Acupuncture plus auricular point sticking can produce a satisfactory efficacy in treating PCOS.
2.Compression-screw Fixation in Treating Carpal Navicular Fractures——A Report of 9 Cases
Fangrui MEI ; Weiquan ZENG ; Cheng GU ; Donghai LIU
Journal of Third Military Medical University 1983;0(04):-
This paper is to report our experience of using the internal fixation with compression-screw to treat 9 fractures of carpal navicular bone including two fresh) two old and 5 non- union cases.The mean follow-up time of the 9 cases was one year. Two fresh and 2 old fractures healed uneventfully and so did the 2 cases out of the 5 non-unions. The symptoms, however, disappeared in all the cases and the function of the wrist was or nearly was normal. All the patients resumed their original work.It is believed that this method of internal fixation with compression-screw is simple and easy to perform. Its effect is reliable. No external fixation is needed after the operation. And the function of the wrist can be restored after a short period of treatment.It is suggested that the indications of this operative treatment are non-union cases without ischemic necrosis, unstable fresh fractures with displacement and fractures in the proximal third or half of the navicular bone.
3.Exploring the effect of Tuina on the dendritic structure of spinal cord dorsal horn in rats with lumbar disc herniation based on NR2B/PSD-95 pathway
Huanzhen ZHANG ; Bingqian WANG ; Shuijin CHEN ; Lechun CHEN ; Jingjing JIANG ; Yu JIANG ; Jincheng CHEN ; Hongye HUANG ; Jiayu FANG ; Weiquan ZENG ; Zhigang LIN
Journal of Acupuncture and Tuina Science 2023;21(2):129-136
Objective: To investigate the analgesic mechanism of Tuina (Chinese therapeutic massage) by observing the effect of the N-methyl-D-aspartate receptor subunit 2B (NR2B)/postsynaptic density-95 (PSD-95) pathway on the dendritic structure of spinal cord dorsal horn in rats with lumbar disc herniation. Methods: Fifty Sprague-Dawley rats were randomly divided into a blank group, a model group, a Tuina group, a blocker agent group, and a blocker agent + Tuina group. The sciatic nerve chronic constriction injury (CCI) model was prepared by the sciatic nerve ligation method. From the 4th day after modeling, rats in the Tuina group and the blocker agent + Tuina group were subject to daily Tuina intervention, and those in the blocker agent group and the blocker agent + Tuina group were daily intrathecally injected with NR2B blocker agent (MK-801). The spontaneous pain score was used to observe the pain behavior of all rats. The expression levels of NR2B and downstream PSD-95 were measured by immunohistochemistry, and the dendritic structure changes were observed by Golgi staining for rat spinal cord dorsal horn after 14 d of continuous intervention. Results: Compared with the blank group, the degree of rat spontaneous pain after CCI was elevated in both the model and the Tuina groups (P<0.01) and was reduced in the Tuina group after the Tuina intervention compared with the model group (P<0.05). Compared with the model group, the rat spontaneous pain level after blocking NR2B was reduced in both the blocker agent group and the blocker agent + Tuina group (P<0.05). The NR2B and PSD-95 protein levels were significantly higher in the model group compared with the blank group (P<0.01); the total number of dendritic branches was increased (P<0.01), and the total dendritic length became longer (P<0.01) in the spinal cord dorsal horn. The rat NR2B and PSD-95 protein levels were significantly decreased in the Tuina group compared with the model group (P<0.01); the total dendritic branch number was reduced (P<0.01) and the total length was shortened (P<0.01) in the spinal cord dorsal horn. After blocking NR2B, the expression levels of NR2B and downstream PSD-95 protein were significantly lower in both the blocker agent group and the blocker agent + Tuina group compared to the model group (P<0.01). The total branch number was significantly reduced (P<0.01), and the total length was significantly shortened (P<0.01) of the dendrites in the spinal cord dorsal horn. Conclusion: Tuina may exert an analgesic effect by remodeling the dendritic structure in the spinal cord dorsal horn in rats with lumbar disc herniation, and its mechanism may be related to the inhibition of NR2B/PSD-95 signaling pathway.