1.Influence of different dose α-lipoic acid on blood glucose and C-reaction protein in type 2 diabetic patients with macroangiopathy
Clinical Medicine of China 2016;32(6):533-536
Objective To discuss the influence of different dose α-lipoic acid on blood glucose and C-reaction protein(CRP) in type 2 diabetic patients with macroangiopathy.Methods Seventy-two cases type 2 diabetic patients with macroangiopathy were divided randomly and voluntarily into the conventional dose group(n=36) and high dose group(n=36).The patients of conventional dose group were given conventional dose α-lipoic acid(300 mg/d) based on glucose treatment while high dose group were given high dose α-lipoic acid (600 mg/d) based on glucose treatment,the courses were all 15 d.The fasting blood glucose(FBG),2 h postprandial blood glucose(2 hBG),serum CRP of before and after treatment of between the two groups and safety during the treatment were compared.Results The FBG,2 hBG and CRP of before and after treatment were respcetively (9.24±2.18) mmol/L and (8.18±1.38) mmol/L,(13.26±3.17) mmol/L and (11.26±1.63) mmol/L,(21.52±4.17) mg/L and (14.72±3.73) mg/L;(9.26±2.04) mmol/L and (5.82±1.27)mmol/L,(13.52±2.45) mmoL/L and (8.92±1.04) mmol/L,(22.65±4.67) mg/L and (8.61±1.52) mg/L,all groups decreased obviously,the differences were statistically significant compared to that of before treatment(t=4.265,4.654,4.956 and 5.562,6.254,7.654,P<0.05),and the high dose group showed more lower (t=5.353,5.783,6.257,P<0.05).After treatment,ALT ((37.26±9.64) U/L),AST ((38.22±7.04) U/L),BUN((7.25±1.52) mmol/L) and Scr((55.25±11.25) mmol/L) of all groups increased obviously than pretreatment((33.53±6.37) U/L,(33.15±7.16) U/L,(5.43±4.67) mmol/L,(53.15±13.65) mmol/L),but the differences were no statistically significant compared to that of before treatment (t=-2.061,-2.165,-1.455,-0.689,P<0.05),and there were also no statistical significance between the two groups(t =2.125,3.026,1.235,1.035,P<0.05).Conclusion α-lipoic acid can obviously decrease the blood glucose and CRP in type 2 diabetic patients with macroangiopathy,which has a significant dose effect relationship,and is safe and worthy of clinical application.
2.Relevance research between blood inflammatory factor and urinary microalbumine in type 2 diabetic patients
Clinical Medicine of China 2012;28(10):1019-1021
Objective To investigate the significance of changes of serum high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-alpha (TNF-α),interleukin 6 (IL-6) and urinary microalbumine levels in patients with diabetic kidney disease.Methods Serum hs-CRP,TNF-α,IL-6 and urinary microalbumine levels were measured with RIA in 60 type 2 diabetic patients and 20 controls.The 60 diabetic patients were divided into three groups based on urine albumin excretion rate.Group A:without alblminuria ( UAER < 20 μg/ min,n =20 ) ; Group B:micro-albuminuria ( UAER < 200 μg/min,n =20 ) ; Group C:macro-albuminuria ( UAER > 200 μg/min,n =20 ).The serum levels of hs-CRP,TNF-α,IL-6 of patients in the four groups were measured.Results The serum levels of hs-CRP,TNF-α,IL-6 of patients in the healthy group were ( 1.21 ± 0.87 ) mg/L,( 1.27 ± 0.93 ) ng/L and ( 4.31 ± 1.72 ) ng/L,in the nonalbuminuria group were ( 2.31 ± 1.07 ) mg/L,( 1.95 ± 1.34 ) ng/L and ( 5.79 ± 1.68 ) ng/L,in the microalbuminuria group were ( 3.47 ± 1.25 ) mg/L,(2.86 ± 1.26) ng/L,(7.13 ± 1.57 ) ng/L,in the macroalbuminuria group were (4.83 ± 1.47 ) mg/L,(4.03 ±1.43)ng/L,(9.14 ±2.43)ng/L Serum levels of hs-CRP,TNF-α and IL-6 were significantly higher in all the patients with type 2 diabetes than those in the control group (P < 0.01 ).Serum levels of hs-CRP,TNF-α and IL-6 were significantly higher in type 2 diabetic patients with microalbuminuria than those in patients without albuminuria (P <0.05).Serum levels of hs-CRP,TNF-α and IL-6 were significantly higher in diabetic patients with macroalbuminuria than those in patients with micrealbuminuria (P < 0.01 ).The levels of hs-CRP,TNF-αand IL-6 were positively related to the urinary microalbumine levels ( rs =0.67,0.64,0.75,P < 0.01 ).Conclusion Determination of serum hs-CRP,TNF-α and IL-6 levels might be helpful for early detection of diabetic kidney disease and monitoring the progress of the disease process.
3.Expression of recombined human immunoglobulin ? light chain 022 and TOM1 mRNA in omental adipose tissues of patients with type 2 diabetes and insulin resistance
Academic Journal of Second Military Medical University 2001;0(09):-
Objective:To investigate the expression of recombined human immunoglobulin ? light chain 022 and TOM1 gene and to determine the protein expression of HSIGVL022 in omental adipose tissues of patients with type 2 diabetes and insulin resistance(T2DM-IR).Methods: Fat tissues from greater omentum of T2DM-IR patients and normal controls were obtained.The mRNA levels of recombined human immunoglobulin ? light chain 022 and TOM1 were measured by fluorescent quantitative RT-PCR;expression of HSIGVL022 protein was identified by immunohistochemistry.Results: The mRNA levels of HSIGVL022 and TOM1 in T2DM-IR patients were(34 140?6 160) copy/million house-keeping genes and(4 440?617) copy/million house-keeping genes,respectively;those in control group were(5 930?661) copy/million house-keeping genes and(1 360?82) copy/million house-keeping genes,respectively.There were significant difference between the 2 groups(P
4.Effect of Dexamethasone on Plasma Atrial Natriuretic Peptide Levels during Hemorrhagic Shock in Dogs
Academic Journal of Second Military Medical University 1985;0(05):-
Ten healthy mongrel dogs of either sex were divided into two groups: Dex-treated group (n=6) and NS-treated group (n=4). The dogs were attacked with hemorrhagic shock by bleeding via left femoral artery. Dex-treated group was given Dexamethasone (5mg/kg) at mean arterial pressure (MAP) of 13.3 kPa. NS-treated was given placebo of 0.9% Nad solution. The atrial natriuretic peptide (ANP) was determined by radioimmunoassay. Plasma level of ANP decreased progressively 5 h after shock. There was a significant positive correlation between the extent of reduction of MAP and that of plasma ANP (r=0.871203, n=16, P
5.Clinical analysis of pulmonary fungal infection in intensive care unit
Journal of Chongqing Medical University 2007;0(08):-
Objective:To investigate the risk factors of pulmonaryfungal infection in intensive care unit(ICU),and discuss the strategy of prevention and treatment.Methods:Thirty-four patients with pulmonary fungal infection in ICU of our Hospital from Jan.2004 to Jan. 2009 were analyzed retrospectively,including primarily diseases,application of antibiotics,adrenal cortical hormone and virulence opera-tion,therapy and turnover.Results:All patients were accepted the therapies of broad spectrum antibiotics and glucocorticoids for long time before definite diagnosis of pulmonary fungal infection.Theire average time that the patients staying in hospital was 45.6 d.The clinical symptoms and imaging examinations were untypica.l Blastomyces albicans was the main pathogen.After the antifungal agents and supportive treatment used in time,33cases(97%)were cured and 1cases(3%)died.Conclusion:The major risk factors of children pulmonary fungal infection are long-time use of broad spectrum antibiotics and glucocorticoids.The pulmonary fungal infection can decrease by rationaluse of broad spectrum antibiotics and glucocorticoids,decreasing the unnecessary invasive operations,strengthening the supportive therapies ofmicro-ecosystem,and applying the antifungal agents in time.
6.Analysis on YE Tian-shi's academic thinking about'applying diaphoresis to treat syndrome of defensive phase'
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(06):-
The therapeutic method of defensive,qi,nutrient and blood phases in Treatise on Epidemic Febrile Diseases is the signif icant achievement of YE Tian-shi in the process of studying febrile disease.Among the total,the syndrome of defensive phase should be treated on basis of syndrome differentiation,if only using diaphoresis without syndrome differentiation will result in damaged yin and replenished pathogen and deteriorated syndrome.It has important theoretical and clinical meaning to know law and characteristics of febrile disease in lung-wei phase by understanding'applying diaphoresis to treat syndrome of defensive phase'.
7.Pathogenic Bacteria in Plateau Hospital-Acquired Pulmonary Infection and Antimicrobial Susceptibility
China Pharmacy 2001;0(11):-
OBJECTIVE: To clarify the pathogens in plateau hospital-acquired pulmonary infection and their antimicrobial susceptibility so as to provide scientific basis for clinical first-line treatment in the rational use of antibacterial drugs. METHODS: The bacteriological culture and drug susceptibility experiment on sputum and bronchial douche fluid collected from 1 396 patients with hospital-acquired pulmonary infection in our hospital from 2004 to 2006 as well as the filed medical records were analyzed retrospectively. RESULTS: 789 positive bacteria were isolated, of which, 77.82% (614/789) were gram-negative bacilli (GNB), with Klebsiella spp showing the highest percentage, accounting for 53.91% (331/614); 21.04% (166/789) were gram-positive bacteria, with staph showing the highest percentage, accounting for 46.99% (78/789).Most of the GNB were sensitive to imipenem, sulbactam/cefoperazone, then to aminoglycosides. The susceptibility rate of Gram-positive bacteria to vancomycin was 90.36%. CONCLUSION: Gram-negative bacilli were the main hospital infection pathogens, which were sensitive to imipenem, sulbactam/cefoperazone but highly resistant to ceftazidime, which calls for attention in the clinic.
8.The Clinical Observation on the Treatment of Stroke Sequela by Traditional Chinese Syndrome Differentiation
International Journal of Traditional Chinese Medicine 2009;31(5):421-422
To study the clinical effect of treating the sequela of wind stroke by the traditional Chinese medicine integrated with western medicine. 80 patients were randomly recruited into a treatment group (50 cases) and a control group (30 cases). In the control group, conventional western medicines were applied, while in the treatment group traditional Chinese medicine based on syndrome differentiation was applied on the basis of the control group. The total effective rate of the treatment group and the control group was 73.58% and 54.6% respectively, demonstrating a statistically difference (X2= 6.66, P<0.01).
9.Development of ECG Holter Based on SD Card
Chinese Medical Equipment Journal 1989;0(04):-
Objective To design a holter, which can record ECG for long time. Methods SD(secure digital) card was adopted as mass storage medium. The preprocessed ECG signals were converted into digital data which were stored temporarily into SD card by the USB-2.0-spicified microcontroller CY7C68013A. Results SPI bus was introduced for data communication between the host and SD card. The LCD module was utilized to display the menu and states of the system. The data stored in SD card were transmitted to a PC via the USB, or read by a specified card reader.1 GB SD card could record for about one month. Conclusion The portable design of this device is convenient for outgoing.
10.Advances in the diagnosis and treatment of acute heart failure
Chinese Journal of Practical Internal Medicine 2001;0(03):-
Acute heart failure is defined as a rapid onset or change in the signs and symptoms of heart failure,resulting in the need for urgent therapy.This article reviews new information relating to the diagnosis and treatment of AHF.