1.Erythropoietin therapy for anemic patients with non-small cell lung cancer in combination chemotherapy
Zhaoxia WANG ; Weijian SHI ; Keming WANG
China Oncology 1998;0(04):-
150 g/L, the dose of EPO was decreased by half. The control group consisted of 20 patients given Leucogenum, the dose was 20 mg every time, 3 times per day. Results: From the fourth week after therapy, the Hb, HCT, RBC of the EPO treatment group was significantly higher than prior to treatment( P
2.Variation of plaque pH values after chewing xylitol gum
Yan SI ; Weijian WANG ; Wenhui WANG
Journal of Practical Stomatology 1995;0(04):-
0.05). When comparing the pH value of xylitol gum with the pH value of 0.1 kg/L sucrose solution, and comparing that with the sucrose gum, significant difference could be found between the changes of pH values at different time points (P
3.Analysis of diagnostic and handling procedures of the first imported case of A/H1N1 influenza in mainland China
Weijian HU ; Jiayu WU ; Xiaomei WANG
Chinese Journal of Emergency Medicine 2009;18(6):576-579
Objective The patient started from St. Louis (U. S.), and reached Chengdu (China) after 3 days of flight(St. Louis- Tokyo- Beijing - Chengdu). The patient felt unwell, so he and the two relatives took a taxi to the Emergency Center of Sichuan Provincial People' s Hospital for treatment. The epidemiological survey showed that, the patient had been living in the University of Missouri in the United States, no pigs died locally, there were no markets for the living pigs, farmers markets, farms, and slaughterhouses, and he hadn't contact with pigs. But 4 days before the onset, he closely contacted with a schoolmate, who had cold symptoms. The pa-tient had never been to virus laboratory 7 days before the onset. Clinical examinations showed that, the patient had a fever (37.8 ~ 38.8℃), WBC 7.9×10-9 L-1, N 5.475 × 10-9 L-1, L 19.5% ;the chest X-ray shewed that texture increased and the heart shadow augmented on both lungs; the result of throat swab culture was negative. The result of virus nucleic aeid detected by Sichnan Provincial Center for Disease Control showed H1N1 influenza virus, suspected. Sichuan Province Health organization organized experts on the prevention and control of H1N1 influenza for consultation, and the patient was diagnosed as the first suspected H1N1 influenza case in mainland China based on the epidemiological investigation, symptoms and signs of the patient, the results of laboratory ex-amination, and the result of virus test. Confirmed by the experts from Chinese center for disease control and pre-vention and The Ministry of Health of the People's Republic of China, the patient was diagnosed as the first H1N1 influenza case in mainland China.
4.EFFECTS OF PHLOROGLUCINOLS FROM DRYOPTERIA CRASSIRHIZOMA NAKAI ON ULTRASTRUCTURE AND RESPIRATION IN LEUKEMIA P388 CELLS
Weijian XUE ; Shixian WANG ; Dehua LI
Chinese Pharmacological Bulletin 1986;0(05):-
Phloroglucinol is an antineoplastic effective compound from Dryopteria Crassirhizoma Nakai. In this study, mice implanted with leukemia P388 were examined under an electron microscope. It' was found that the leukemia bearing mice, which had been injected with phloroglucinol exhibited degeneration and swelling of mitochondria in the P38'8 cells. Measurement with an oxygen electrode showed that the drug treatment of P388 cells markedly lowered their oxygen consumption in comparison with the control cells .The results demonstrate that phloroglucinol inhibits respiration of tumor cells. Probably, the mitochondria of tumor cells is a target that the drug attacks.
5.Endovascular stenting of carotid stenosis in patients at high surgical risk
Bin DU ; Weijian JIANG ; Yongjun WANG
Journal of Interventional Radiology 1994;0(04):-
Objective To evaluated the safety and complications of endovasdcular stenting for symptomatic carotid stenosis with surgical high risk.Methods A series of 11 vessels in 9 patients at surgical high risk were treated by endovascular stenting. The complications during the procedures and postoperative periods were analyzed within one to five months. Results All of the operations were successfully performed without any serious complications. During the follow up period (averaging 6 months), there were no complications of TIAs, stokes and restenoses.Conclusions The study suggests that endovascular stenting may be safe and effective for patients at surgical high risk, but further more study is needed.
6.The clinical evaluation of Nd:YAG laser in the treatment of dentine hypersensitivity
Hongqing WANG ; Weijian ZHONG ; Xiaofu QU
Journal of Practical Stomatology 1996;0(02):-
Objective: To investigate the effects of Nd:YAG laser in the treatment of dentine hypersensitivity. Methods:270 teeth in 153 patients were equally divided into two groups at random. The teeth in the experimental group were treated with Nd:YAG laser at 265.5 J/cm 2 (0.75 W and 10 Hz for 2 min) for 3 times with the interval of 1 week, those in the control group were treated with Gluma desensitizer for 3 times with the interval of 2 d. Results:The effective rate of the experimental and control groups was 92.59% and 49.62% respectively (P
7.Washed platelets at low concentration promote the proliferation of human dental pulp cells
Duan JIANMIN ; Wang WEIJIAN ; Kikuchi HIROTAKA
Journal of Practical Stomatology 2000;0(05):-
Objective:To investigate the effects of washed platelets at low concentration(WPLT)on the proliferation of human dental pulp cells(HDPCs).Methods:WPLT was prepared from a male venous blood,cultured HDPCs were exposed to the WPLT at 50 ml/L,100 ml/L and 200 ml/L for 0.5~24 h respectively.Cell proliferation and prostaglandin E_2 production were examined by cell counting and Prostaglandin E_2 EIA Kit-Monoclonal respectively.Cyclooxygenase-2(COX-2)mRNA expression was determined by real time RT-PCR.Results:WPLT at 50 ml/L promoted HDPC proliferation and increased COX-2 mRNA expression at 3-hour-exposure.That at 50~200 ml/L increased the production of PGE_2 dose-depandently.Indomethacin or dexamethasone reduced WPLT-induced HDPC proliferation,and this inhibitory effect was reversed by exogenous PGE_2.PGE_2 promoted HDPC proliferation at 5-100 ng/ml.Conclusion:WPLT may induce prostaglandin E_2 production,thereby promote HPDC proliferation.
8.Effects of diazoxide preconditioning on anosda-reoxygenation induced apoptosis in rat hippocampai neurons
Weijian WANG ; Rongguo LIU ; Chunxia SHI
Chinese Journal of Anesthesiology 1994;0(03):-
Objective To determine what effects diazoxide, a selective opener of mitochondrial ATP-sensitive potassium channel ( Mito-KATP ), exerts on apoptosis in hippocampal neurons caused by anoxia-reoxygenation.Methods Newborn SD rats (
9.Effect of multi-disciplinary team on management of multidrug-resistant organisms
Hong WANG ; Meiling YI ; Weijian DING ; Jun PENG ; Qiuhong TAN
Chinese Journal of Infection Control 2015;(12):846-848
Objective To investigate the detection of multidrug-resistant organisms (MDROs)in a hospital, evaluate the efficacy of multi-disciplinary team(MDT)on management of MDROs,and provide guidance for effective control on MDRO infection.Methods From October 2013 to September 2014,compliance to comprehensive inter-vention measures in clinical departments in different stages as well as detection of MDROs from patients were com-pared respectively.Results Compliance to comprehensive intervention measures showed an overall upward trend from the fourth quarter of 2013 to the first,second,and third quarters of 2014,difference was statistically signifi-cant (all P <0.001 ).From the fourth quarter of 2013 to the third quarter of 2014,the percentage of the major MDRO strains in the same species of bacteria were:methicillin-resistant Staphylococcus aureus (MRSA)52.34%, 45.45%,48.95%,and 26.25% respectively;carbapenem-resistant Acinetobacter baumannii (CRAB)64.42%, 63.07%,59.87%,and 43.09% respectively;multidrug-resistant Pseudomonas aeruginosa (MDRPA)42.11 %, 41 .82%,29.33%,and 17.52% respectively;the detection rate of MRSA,CRAB,and MDRPA showed an overall downward trend,difference among different stages were statistically significant (all P <0.001 ).Detection rates of carbapenem-resistant Enterobacteriaceae (CRE)and vancomycin-resistant Enterococcus (VRE)were both low (<5%),difference among different stages were not statistically significant (all P >0.05).Conclusion MDT on man-agement of MDROs is helpful for reducing the emergence and spread of MDROs.
10.The effect of the bedside protection against different operators in percutaneous coronary intervention
Zhiting WANG ; Guoquan CAO ; Miao MIAO ; Weijian HUANG ; Zhouqing HUANG
Chinese Journal of Radiological Medicine and Protection 2015;35(9):709-712
Objective To discuss the effect of the bedside shielding protection on the first and second operators against position radiation in percutaneous coronary intervention.Methods The surface entrance dosage rate for the first and second operators at 125 cm height with and without radiation protection shielding (provided separately) were measured.The t-test was used for statistical analysis of arithmetic mean values of dosage rates.And the effect of bedside shielding protection was calculated.Results The position radiation dosage rate at which the first operator exposed was significantly higher than that for the second in the case of no bedside protection (t =97.1-2 263.0,P < 0.05),whereas the dosage rate at which the first operator (except for the left foot position) exposed was significantly lower than that for the second in the case of no bedside protection (t =-80.9-275.1,P < 0.05).The shielding effect of bedside protection on the first and second operators was in the range of 92.26%-99.36% and 27.83%-97.90%,respectively.Conclusions The bedside protection may effectively reduce position radiation dose to patients and the use of bedside protection changed the trends in the dose distribution in operators' standing region.Attention should be focused on the radiation protection of the second operators in daily work by making full use of bedside protection.