Objective To observe the clinical effects of levocarnitine combined with sucrose iron injection for treatment of maintenance hemodialysis patients with renal anemia.Methods Forty-four cases of patients with maintenance hemodialysis merged renal anemia were randomly divided into control group (n =22) and treatment group(n=22).All patients were administrated conventional therapy.The sucrose iron injection was administrated with control group at hemodialysis, while treatment group administrated levocamitine after hemodialysis on this basis.The hemoglobin (Hb) and erythrocyte specific volume (Hct) were compared after treatment for 8 weeks,and the clinical effects were evaluated.Results After treatment for 8 weeks, the Hb and Hct(treatment group: (105.69±11.94) g/L, (0.31±0.04);control group: (86.31±11.39) g/L,0.27±0.05) had increased significantly compared with prior treatment(treatment group:(62.65± 12.74) g/L, (0.19±0.04;control group: (63.33 ± 13.23) g/L, 0.20± 0.06) in two groups, and the treatment group increased more significant than control group accompanied with significant statistically difference (t =3.197,2.978;P ＜0.05).Also,the total effective rate of treatment group was 86.4％(19/22) ,which higher than control group(50.0％ (11/22)) accompanied with significant statistically difference (x2 =6.705, P＜0.05).Conclusion The therapy of levocarnitine combined with sucrose iron injection can obviously improve anemia symptoms in patients with maintenance hemodialysis and worthy of popularization and application.

Objective To observe the changes of carbohydrate antigen 19-9 (CA19-9) in type 2 diabetes mellitus (T2DM) patients,and determine the positive boundary value of CA19-9 for differentiating digestive tract malignant tumor and T2DM.Methods The clinical data of 300 cases were retrospectively analyzed.The patients were divided into 3 groups:group A with 100 T2DM patients,group B with 80 tumor patients and group C with 120 non-tumor and non-diabetic mellitus normal people.Chemiluminescence was used to determine the serum CA19-9 level,and the results of the 3 groups were analyzed.Results The serum CA 19-9 levels in group A and group B were significantly higher than that in group C [(21.38 ± 18.23),(32.21 ± 19.00) kU/L vs.(11.21 ± 10.08) kU/L],and there were statistical differences (P ＜0.05).Furthermore the serum CA 19-9 level in group B was significantly higher than that in group A,and there was statistical difference (P ＜ 0.05).The serum CA19-9 level was associated with fasting plasma glucose (r =0.527,u =5.144,P ＜ 0.01),2 h postprandial blood glucose (r =0.617,u =6.044,P ＜ 0.01),fasting insulin (r =0.427,u =4.144,P ＜ 0.01),and glycosylated hemoglobin (r =0.507,u =4.881,P ＜ 0.01),while the serum CA19-9 level was not associated with serum creatinine and courses of T2DM.CA19-9 ROC curve was used to determine 45.0 kU/L as the positive boundary value between the group A and group B.Conclusions The serum CA 19-9 level of T2DM patients is higher than that of normal people,but lower than that of patients with digestive tract malignant tumor.The serum CA 19-9 level is associated with blood glucose and glycosylated hemoglobin.The 45.0 kU/L as serum CA19-9 level positive boundary value can significantly improve the diagnosis value of digestive tract malignant tumor.

OBJECTIVE:To evaluate the physiochemical characteristics of resin restorative material and its clinical application in repairing dental caries.METHODS:Related papers published between January 1995 and January 2010 were searched using key words of "dental caries,resin,restoration,dental pulp,wear resistance and hardness" both in English and Chinese from databases of Medline and Chinese Journal Full-text Database.RESULTS:As a kind of cosmetology repair material,the color of resin restorative material is similar to the natural teeth,and exhibits strong bonding force to enamel.But,the mechanical features of which is smaller than dental amalgam.The composite resin commonly comprised crystalline quartz and fumed silica,which had advantages of insufficient mechanical strength,poor wear resistance and great polymerization shrinkage.Recently,the research of resin gained breakthrough and newly typed composite resin was developed.Though the mechanical strength has been notably improved,it is still far from the requirement.The polymer-metal nano-resins,such as tantalum oxide nanoparticles and zirconia-based resin,can not only enhance the strength,decrease polymerization shrinkage,but also exhibit good appearance and surface properties,therefore are themost promising materials.CONCLUSION:At present,plenty of resin restorative materials were used in caries fillings with own advantages and disadvantages.Novel composite resin would be widely used in future due to its unique superiority.

OBJECTIVE: Dental implantation is one of effective method to repair defect and dentition. Therefore, it has wide perspective for clinical application. This study was designed to evaluate physicochemical property and clinical application of dental implant materials.METHODS: A computer-based online search was conducted in Medline for English language publications containing the key words of "dental implant, biocompatibility" from January 1999 to November 2009. Relevant data were also searched from CNKI with the same key words in Chinese from January 1999 to November 2009.RESULTS: With the development of medical materials, metal, ceramics, high polymer, composite materials, and nano-materials played important roles in dental implantation. Biochemical function, including biological morphology and correlation with adjacent soft and sclerous tissues, of the implanted teeth becomes a hot topic in modern tooth implantation. Nanometer technique, as a novel technique of living and life materials, becomes a hot research in oral implantology.CONCLUSION: Varying materials have been applied for tooth implantation, while nano-materials are developing for replacing traditional implant materials.

Objective To study the correlation between the polymorphism of Interferon γ( IFN-γ) ( + 874 T/A) gene and susceptibility to the development of lung cancer. Methods The polymorphism of IFN-7 gene( + 874 T/A) in 42 patients with lung cancer and 60 healthy control subjects was detected by using sequence-specific primers polymerase chain reaction( PCR-SSP) and their susceptibility to development of lung cancer was analyzed. Results The genotypic frequencies of AA of IFN -γ Gene( + 874 T/A) in the control group and the patient group were 0. 533, 0.786 .respectively and the genotypic frequency of AA in control group was significantly lower than that in the patient group ( P < 0. 01) , in contrast with which the genotypic frequencies of AT and TT in the control group were significantly higher than those in the patient group (P < 0. 01 ,P < 0.05). The A allele frequency of IFN-γ gene in the patient group was statistically higher compared with that in the control group(0. 869 vs. 0.7 ,P <0.01 ) ,in which the relative riskrate(RR) was 2.84,95%CI 1. 31 ~6.15 ,P<0. 01. Conclusion The polymorphism of IFN-γ gene ( +874 T/ A) could be associated with susceptibility to the development of lung cancer,so it could be considered one of the genetic markers to be used to early identify individuals at high risk of lung cancer.

OBJECTIVE:To evaluate the economic effects of artesunate(ART)versus Quinine MAX(QUI)in treating malaria.METHODS:A total of 64 patients with malaria were randomly assigned to receive ART or QUI for 7 days,with cost-minimization analysis conducted on the 2 therapeutic scheme.RESULTS:The average cost for ART vs.QUI scheme was 341 yuan vs.485 yuan,showing significant differences between the 2 schemes(P0.05).CONCLUSION:The artesunate is preferable compared with QUI and could be popularized in poverty-striken area such as Africa.

Objective To discuss the effect of correct limb emplacement on the prevention of shoulder pain of patients with cerebral apoplexy. Methods Forty-one patients after cerebral apoplexy with motor dysfunction of upper limbs but with no sensory disability and shoulder pain were randomly divided into the control group (20 cases)and the observation group (21 cases).Both two groups received routine passive activity and massage of limbs.The observation group was given correct limb emplacement based on routine nursing. Then we evaluate the pain of ariticulus humeri when in the full range of anterior flexion movement after two months. Results The incidence of shoulder pain in the control group was 65.0%,which was statistically lower than that of the observation group (19.0%), χ2=8.91,P ＜ 0.01. Conclusion Correct limb emplacement had preventive effect on patients with cerebral apoplexy.

Fresh healthy human erythrocytes were treated by four kinds of bile acid solution (DOC, GDC, C-Na and GC-Na) at physiological and pathological concentrations of human serum level. The more hydrophobic bile acids (DOC and GDC) significantly affected lipid components of erythrocyte. membranes and morphology at concentration of 0.5 mmol/L and 1.0 mmol/L. To the extent of he-molysis DOC and GDC were more hemolytic than C-Na and GC-Na. Additionally the erthrocytes from patients with biliary obstruction were also studied. The results suggest that the more hydropho-bicity of bile acid, the more erythrocyte damage. The hydrophobicity was associated with the structure of bile acid molecules.

Objective: To explore the hemostasis mechanisms of Radix Rubiae and charred Radix Rubiae.Methods: The effects of Radix Rubiae and charred Radix Rubiae were compared in terms of the clotting time,bleeding time,blood platelets count and capillary permeability on mice,and the TT,PT and APTT on pathologicalbleeding models incurred by Heparin and Warfarin and rats.Results: Radix Rubiae and charred Radix Rubiaeall canrestrain the capillary permeability of abdominal cavity in mouse,and obviously shortenthe TT,PT and APTT of rat,but charred Radix Rubiae was more effective than Radix Rubiae.The large and small doses of Radix Rubiae and the large dose of charred Radix Rubiae can elevate the blood platelets count,and obviously antagonize Heparin and Warfarin,and Radix Rubiae was more effective than charred Radix Rubiae.Conclusion: Radix Rubiae has the hemostasis effect through elevating the blood platelets count and antagonizing Heparin and Warfarin,but charred Radix Rubiae through restraining the capillary permeability and shortening the TT,PT and APTT.They have different hemostasis mechanisms.

TCM treatment for cancer ous fever puts more emphasis on syndrome differentiation and treatment. This article recognized that the treatment for cancerous fever needs not only syndrome differentiation and treatment, but also the combination of disease differentiation and syndrome differentiation by reviewing the treatment of a case of cancerous fever. Combination of disease differentiation and syndrome differentiation will obtain good efficacy.