Objective To study the effects of different doses of atorvastatin on serum homocysteine (Hcy) and matrix metallopmteinase-9 (MMP-9) in patients with acute cerebral infarction.Methods Ninety-patients with acute cerebral infarction were randomly divided into two groups,the observation group (n =45 cases) and the control group(n =45 cases).The patients in the observation group were treated by the conventional therapy plus atorvastatin 40mg/d,while the patients in the control group were treated by the conventional therapy plus atorvastatin 20mg/d.Hcy and MMP-9 were detected before and after treatment for one month.Results The total effective rate was 95.6％in the observation group and 86.7％ in the control group.There was significant difference between two groups(x2 =2.1951,P ＜ 0.05).Hcy and MMP-9 were decreased after treatment in both groups and those in the observation group were lower than in the control group (all P ＜ 0.05).Conclusion High-dose atorvastatin can improve patients with acute cerebral infarction through decreasing Hcy and MMP-9.

Objective To discuss the effect of correct limb emplacement on the prevention of shoulder pain of patients with cerebral apoplexy. Methods Forty-one patients after cerebral apoplexy with motor dysfunction of upper limbs but with no sensory disability and shoulder pain were randomly divided into the control group (20 cases)and the observation group (21 cases).Both two groups received routine passive activity and massage of limbs.The observation group was given correct limb emplacement based on routine nursing. Then we evaluate the pain of ariticulus humeri when in the full range of anterior flexion movement after two months. Results The incidence of shoulder pain in the control group was 65.0%,which was statistically lower than that of the observation group (19.0%), χ2=8.91,P ＜ 0.01. Conclusion Correct limb emplacement had preventive effect on patients with cerebral apoplexy.

Objective To study the correlation between the polymorphism of Interferon γ( IFN-γ) ( + 874 T/A) gene and susceptibility to the development of lung cancer. Methods The polymorphism of IFN-7 gene( + 874 T/A) in 42 patients with lung cancer and 60 healthy control subjects was detected by using sequence-specific primers polymerase chain reaction( PCR-SSP) and their susceptibility to development of lung cancer was analyzed. Results The genotypic frequencies of AA of IFN -γ Gene( + 874 T/A) in the control group and the patient group were 0. 533, 0.786 .respectively and the genotypic frequency of AA in control group was significantly lower than that in the patient group ( P < 0. 01) , in contrast with which the genotypic frequencies of AT and TT in the control group were significantly higher than those in the patient group (P < 0. 01 ,P < 0.05). The A allele frequency of IFN-γ gene in the patient group was statistically higher compared with that in the control group(0. 869 vs. 0.7 ,P <0.01 ) ,in which the relative riskrate(RR) was 2.84,95%CI 1. 31 ~6.15 ,P<0. 01. Conclusion The polymorphism of IFN-γ gene ( +874 T/ A) could be associated with susceptibility to the development of lung cancer,so it could be considered one of the genetic markers to be used to early identify individuals at high risk of lung cancer.

OBJECTIVE: Dental implantation is one of effective method to repair defect and dentition. Therefore, it has wide perspective for clinical application. This study was designed to evaluate physicochemical property and clinical application of dental implant materials.METHODS: A computer-based online search was conducted in Medline for English language publications containing the key words of "dental implant, biocompatibility" from January 1999 to November 2009. Relevant data were also searched from CNKI with the same key words in Chinese from January 1999 to November 2009.RESULTS: With the development of medical materials, metal, ceramics, high polymer, composite materials, and nano-materials played important roles in dental implantation. Biochemical function, including biological morphology and correlation with adjacent soft and sclerous tissues, of the implanted teeth becomes a hot topic in modern tooth implantation. Nanometer technique, as a novel technique of living and life materials, becomes a hot research in oral implantology.CONCLUSION: Varying materials have been applied for tooth implantation, while nano-materials are developing for replacing traditional implant materials.

OBJECTIVE:To evaluate the physiochemical characteristics of resin restorative material and its clinical application in repairing dental caries.METHODS:Related papers published between January 1995 and January 2010 were searched using key words of "dental caries,resin,restoration,dental pulp,wear resistance and hardness" both in English and Chinese from databases of Medline and Chinese Journal Full-text Database.RESULTS:As a kind of cosmetology repair material,the color of resin restorative material is similar to the natural teeth,and exhibits strong bonding force to enamel.But,the mechanical features of which is smaller than dental amalgam.The composite resin commonly comprised crystalline quartz and fumed silica,which had advantages of insufficient mechanical strength,poor wear resistance and great polymerization shrinkage.Recently,the research of resin gained breakthrough and newly typed composite resin was developed.Though the mechanical strength has been notably improved,it is still far from the requirement.The polymer-metal nano-resins,such as tantalum oxide nanoparticles and zirconia-based resin,can not only enhance the strength,decrease polymerization shrinkage,but also exhibit good appearance and surface properties,therefore are themost promising materials.CONCLUSION:At present,plenty of resin restorative materials were used in caries fillings with own advantages and disadvantages.Novel composite resin would be widely used in future due to its unique superiority.

Objective To investigate the irbesartan combined with metoprolol in the treatment of congestive heart failure and effects on serum Brainnatriuretic peptide.Methods 187 patients with chronic congestive heart failure(CHF),were randomly divided into the observation group 94 cases,93 cases of the control group.The control group was given the strong heart,diuresis therapy.The treatment group on the basis of combined with irbesartan,metoprolol.The content of BNP was detected before and after treatment.Results After treatment,the observation group total efficiency is higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the observation group and the control group of BNP were significantly lower,the difference was statistically significant(P＜0.05).Before and after treatment with BNP reduced value comparison between groups,the observation group than in the control group,the difference was statistically significant(P＜0.05).Conclusion The patients with CHF on the basis of routine treatment,combined with irbesartan and metoprolol,can effectively improve the curative effect,decrease the serum level of BNP,improve heart function.

Fresh healthy human erythrocytes were treated by four kinds of bile acid solution (DOC, GDC, C-Na and GC-Na) at physiological and pathological concentrations of human serum level. The more hydrophobic bile acids (DOC and GDC) significantly affected lipid components of erythrocyte. membranes and morphology at concentration of 0.5 mmol/L and 1.0 mmol/L. To the extent of he-molysis DOC and GDC were more hemolytic than C-Na and GC-Na. Additionally the erthrocytes from patients with biliary obstruction were also studied. The results suggest that the more hydropho-bicity of bile acid, the more erythrocyte damage. The hydrophobicity was associated with the structure of bile acid molecules.

Objective To observe the changes of carbohydrate antigen 19-9 (CA19-9) in type 2 diabetes mellitus (T2DM) patients,and determine the positive boundary value of CA19-9 for differentiating digestive tract malignant tumor and T2DM.Methods The clinical data of 300 cases were retrospectively analyzed.The patients were divided into 3 groups:group A with 100 T2DM patients,group B with 80 tumor patients and group C with 120 non-tumor and non-diabetic mellitus normal people.Chemiluminescence was used to determine the serum CA19-9 level,and the results of the 3 groups were analyzed.Results The serum CA 19-9 levels in group A and group B were significantly higher than that in group C [(21.38 ± 18.23),(32.21 ± 19.00) kU/L vs.(11.21 ± 10.08) kU/L],and there were statistical differences (P ＜0.05).Furthermore the serum CA 19-9 level in group B was significantly higher than that in group A,and there was statistical difference (P ＜ 0.05).The serum CA19-9 level was associated with fasting plasma glucose (r =0.527,u =5.144,P ＜ 0.01),2 h postprandial blood glucose (r =0.617,u =6.044,P ＜ 0.01),fasting insulin (r =0.427,u =4.144,P ＜ 0.01),and glycosylated hemoglobin (r =0.507,u =4.881,P ＜ 0.01),while the serum CA19-9 level was not associated with serum creatinine and courses of T2DM.CA19-9 ROC curve was used to determine 45.0 kU/L as the positive boundary value between the group A and group B.Conclusions The serum CA 19-9 level of T2DM patients is higher than that of normal people,but lower than that of patients with digestive tract malignant tumor.The serum CA 19-9 level is associated with blood glucose and glycosylated hemoglobin.The 45.0 kU/L as serum CA19-9 level positive boundary value can significantly improve the diagnosis value of digestive tract malignant tumor.

TCM treatment for cancer ous fever puts more emphasis on syndrome differentiation and treatment. This article recognized that the treatment for cancerous fever needs not only syndrome differentiation and treatment, but also the combination of disease differentiation and syndrome differentiation by reviewing the treatment of a case of cancerous fever. Combination of disease differentiation and syndrome differentiation will obtain good efficacy.

Objective To test the relationship between interleukin-1 receptor antagonist(IL-1Ra)gene polymorphisms and the incidence of coronary artery disease and the effect of IL-1Ra gene polymorphisms in prediction cardiovascular events.Methods Polymerase chain reaction was used in a series of 220 patients of coronary arterial disease(CAD)and a control group of 100 cases.A prospective 12 months follow-up was conducted in the CAD patients and cardiovascular events were recorded.Serum levels of total cholesterol,triglyceride,low density lipoprotein cholesterol,fibrinogen,hsCRP,and body mass index were measured.Results There was no significant difference between CAD patients and the control subjects in IL-1Ra gene polymorphisms.However,the IL-1Ra gene polymorphism was significantly higher among subjects in CAD patients without cardiovascular events than those with cardiovascular events.Conclusion It suggests that IL-1Ra gene polymorphisms can not predict the incident of coronary heart disease but might possess some protection for the patients of coronary arterial disease from cardiovascular events.