Objective To observe the clinical effects of levocarnitine combined with sucrose iron injection for treatment of maintenance hemodialysis patients with renal anemia.Methods Forty-four cases of patients with maintenance hemodialysis merged renal anemia were randomly divided into control group (n =22) and treatment group(n=22).All patients were administrated conventional therapy.The sucrose iron injection was administrated with control group at hemodialysis, while treatment group administrated levocamitine after hemodialysis on this basis.The hemoglobin (Hb) and erythrocyte specific volume (Hct) were compared after treatment for 8 weeks,and the clinical effects were evaluated.Results After treatment for 8 weeks, the Hb and Hct(treatment group: (105.69±11.94) g/L, (0.31±0.04);control group: (86.31±11.39) g/L,0.27±0.05) had increased significantly compared with prior treatment(treatment group:(62.65± 12.74) g/L, (0.19±0.04;control group: (63.33 ± 13.23) g/L, 0.20± 0.06) in two groups, and the treatment group increased more significant than control group accompanied with significant statistically difference (t =3.197,2.978;P ＜0.05).Also,the total effective rate of treatment group was 86.4％(19/22) ,which higher than control group(50.0％ (11/22)) accompanied with significant statistically difference (x2 =6.705, P＜0.05).Conclusion The therapy of levocarnitine combined with sucrose iron injection can obviously improve anemia symptoms in patients with maintenance hemodialysis and worthy of popularization and application.

Objective To observe the changes of carbohydrate antigen 19-9 (CA19-9) in type 2 diabetes mellitus (T2DM) patients,and determine the positive boundary value of CA19-9 for differentiating digestive tract malignant tumor and T2DM.Methods The clinical data of 300 cases were retrospectively analyzed.The patients were divided into 3 groups:group A with 100 T2DM patients,group B with 80 tumor patients and group C with 120 non-tumor and non-diabetic mellitus normal people.Chemiluminescence was used to determine the serum CA19-9 level,and the results of the 3 groups were analyzed.Results The serum CA 19-9 levels in group A and group B were significantly higher than that in group C [(21.38 ± 18.23),(32.21 ± 19.00) kU/L vs.(11.21 ± 10.08) kU/L],and there were statistical differences (P ＜0.05).Furthermore the serum CA 19-9 level in group B was significantly higher than that in group A,and there was statistical difference (P ＜ 0.05).The serum CA19-9 level was associated with fasting plasma glucose (r =0.527,u =5.144,P ＜ 0.01),2 h postprandial blood glucose (r =0.617,u =6.044,P ＜ 0.01),fasting insulin (r =0.427,u =4.144,P ＜ 0.01),and glycosylated hemoglobin (r =0.507,u =4.881,P ＜ 0.01),while the serum CA19-9 level was not associated with serum creatinine and courses of T2DM.CA19-9 ROC curve was used to determine 45.0 kU/L as the positive boundary value between the group A and group B.Conclusions The serum CA 19-9 level of T2DM patients is higher than that of normal people,but lower than that of patients with digestive tract malignant tumor.The serum CA 19-9 level is associated with blood glucose and glycosylated hemoglobin.The 45.0 kU/L as serum CA19-9 level positive boundary value can significantly improve the diagnosis value of digestive tract malignant tumor.

Objective: To explore the hemostasis mechanisms of Radix Rubiae and charred Radix Rubiae.Methods: The effects of Radix Rubiae and charred Radix Rubiae were compared in terms of the clotting time,bleeding time,blood platelets count and capillary permeability on mice,and the TT,PT and APTT on pathologicalbleeding models incurred by Heparin and Warfarin and rats.Results: Radix Rubiae and charred Radix Rubiaeall canrestrain the capillary permeability of abdominal cavity in mouse,and obviously shortenthe TT,PT and APTT of rat,but charred Radix Rubiae was more effective than Radix Rubiae.The large and small doses of Radix Rubiae and the large dose of charred Radix Rubiae can elevate the blood platelets count,and obviously antagonize Heparin and Warfarin,and Radix Rubiae was more effective than charred Radix Rubiae.Conclusion: Radix Rubiae has the hemostasis effect through elevating the blood platelets count and antagonizing Heparin and Warfarin,but charred Radix Rubiae through restraining the capillary permeability and shortening the TT,PT and APTT.They have different hemostasis mechanisms.

Fresh healthy human erythrocytes were treated by four kinds of bile acid solution (DOC, GDC, C-Na and GC-Na) at physiological and pathological concentrations of human serum level. The more hydrophobic bile acids (DOC and GDC) significantly affected lipid components of erythrocyte. membranes and morphology at concentration of 0.5 mmol/L and 1.0 mmol/L. To the extent of he-molysis DOC and GDC were more hemolytic than C-Na and GC-Na. Additionally the erthrocytes from patients with biliary obstruction were also studied. The results suggest that the more hydropho-bicity of bile acid, the more erythrocyte damage. The hydrophobicity was associated with the structure of bile acid molecules.

Objective To test the relationship between interleukin-1 receptor antagonist(IL-1Ra)gene polymorphisms and the incidence of coronary artery disease and the effect of IL-1Ra gene polymorphisms in prediction cardiovascular events.Methods Polymerase chain reaction was used in a series of 220 patients of coronary arterial disease(CAD)and a control group of 100 cases.A prospective 12 months follow-up was conducted in the CAD patients and cardiovascular events were recorded.Serum levels of total cholesterol,triglyceride,low density lipoprotein cholesterol,fibrinogen,hsCRP,and body mass index were measured.Results There was no significant difference between CAD patients and the control subjects in IL-1Ra gene polymorphisms.However,the IL-1Ra gene polymorphism was significantly higher among subjects in CAD patients without cardiovascular events than those with cardiovascular events.Conclusion It suggests that IL-1Ra gene polymorphisms can not predict the incident of coronary heart disease but might possess some protection for the patients of coronary arterial disease from cardiovascular events.

By means of the introarterial-injected preparations with oil dye(in some caseswith neuprene latex),the cerebral arterial circle and vertebral-basilar artery of camel(Bactrianus Camelus)were studied in 15 cases.The results obtained are as follows:1.The cerebral arterial circle is composed of two parts,and is formed by theinternal carotid artery intracranial segments and the caudal communicating arteriesas well as their branches of both sides,respectively.66.7 per cent of the caudalcommunicating arteries originate from the carotid rete,33.3 per cent from the inter-nal carotid artery intracranial segment.Anastomosis was found between these twovessels in 46.7 per cent and 20.0 per cent has no communicating branches.This isdifferent from other mammals.The average diameters of the two vessels are 0.216+0.057 cm and 0.178+0.056 cm,respectively.The circle gives the following vessels:rostral cerebral arteries,middle cerebral arteries,caudal cerebral arteries,and thecaudal segment of basilar artery.2.After receiving the branches of occipital artery,the vertebral artery entersinto the cranial cavity and divides to form the cerebral-spinal circle together withbranches on the opposite side.The circle gives rise to the caudal segment of basilarartery and ventral spinal artery.3.The course of the basilar artery differs in no way from the usual patternfound in other mammals,but it is of interest to note that the calibre of this vesselindicate the flow of the blood away the cerebral arterial circle as well as the cere-bral-spinal circle.The vessels arisen from the basilar artery are rostrol cerebellararteries,caudal cerebellar arteries,postpone branches and medullary branches.

Objective To investigate the irbesartan combined with metoprolol in the treatment of congestive heart failure and effects on serum Brainnatriuretic peptide.Methods 187 patients with chronic congestive heart failure(CHF),were randomly divided into the observation group 94 cases,93 cases of the control group.The control group was given the strong heart,diuresis therapy.The treatment group on the basis of combined with irbesartan,metoprolol.The content of BNP was detected before and after treatment.Results After treatment,the observation group total efficiency is higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the observation group and the control group of BNP were significantly lower,the difference was statistically significant(P＜0.05).Before and after treatment with BNP reduced value comparison between groups,the observation group than in the control group,the difference was statistically significant(P＜0.05).Conclusion The patients with CHF on the basis of routine treatment,combined with irbesartan and metoprolol,can effectively improve the curative effect,decrease the serum level of BNP,improve heart function.

Objective To discuss the effect of correct limb emplacement on the prevention of shoulder pain of patients with cerebral apoplexy. Methods Forty-one patients after cerebral apoplexy with motor dysfunction of upper limbs but with no sensory disability and shoulder pain were randomly divided into the control group (20 cases)and the observation group (21 cases).Both two groups received routine passive activity and massage of limbs.The observation group was given correct limb emplacement based on routine nursing. Then we evaluate the pain of ariticulus humeri when in the full range of anterior flexion movement after two months. Results The incidence of shoulder pain in the control group was 65.0%,which was statistically lower than that of the observation group (19.0%), χ2=8.91,P ＜ 0.01. Conclusion Correct limb emplacement had preventive effect on patients with cerebral apoplexy.

OBJECTIVE:To evaluate the physiochemical characteristics of resin restorative material and its clinical application in repairing dental caries.METHODS:Related papers published between January 1995 and January 2010 were searched using key words of "dental caries,resin,restoration,dental pulp,wear resistance and hardness" both in English and Chinese from databases of Medline and Chinese Journal Full-text Database.RESULTS:As a kind of cosmetology repair material,the color of resin restorative material is similar to the natural teeth,and exhibits strong bonding force to enamel.But,the mechanical features of which is smaller than dental amalgam.The composite resin commonly comprised crystalline quartz and fumed silica,which had advantages of insufficient mechanical strength,poor wear resistance and great polymerization shrinkage.Recently,the research of resin gained breakthrough and newly typed composite resin was developed.Though the mechanical strength has been notably improved,it is still far from the requirement.The polymer-metal nano-resins,such as tantalum oxide nanoparticles and zirconia-based resin,can not only enhance the strength,decrease polymerization shrinkage,but also exhibit good appearance and surface properties,therefore are themost promising materials.CONCLUSION:At present,plenty of resin restorative materials were used in caries fillings with own advantages and disadvantages.Novel composite resin would be widely used in future due to its unique superiority.

OBJECTIVE: Dental implantation is one of effective method to repair defect and dentition. Therefore, it has wide perspective for clinical application. This study was designed to evaluate physicochemical property and clinical application of dental implant materials.METHODS: A computer-based online search was conducted in Medline for English language publications containing the key words of "dental implant, biocompatibility" from January 1999 to November 2009. Relevant data were also searched from CNKI with the same key words in Chinese from January 1999 to November 2009.RESULTS: With the development of medical materials, metal, ceramics, high polymer, composite materials, and nano-materials played important roles in dental implantation. Biochemical function, including biological morphology and correlation with adjacent soft and sclerous tissues, of the implanted teeth becomes a hot topic in modern tooth implantation. Nanometer technique, as a novel technique of living and life materials, becomes a hot research in oral implantology.CONCLUSION: Varying materials have been applied for tooth implantation, while nano-materials are developing for replacing traditional implant materials.