0.05). It could protect the survival nephrons. No obvious toxic and side effects were found. It is indicated that Niaoduling capsule is safe and effective for CRF.

OBJECTIVE:To provide reference for rational use of antiviral drugs for hepatitis B viral (HBV) in the clinic. METHODS:The application of antiviral drugs for HBV in a hospital during 2010-2014 was analyzed statistically in respects of con-sumption sum,DDDs,serial number ratio(B/A),etc. RESULTS:Total consumption sum of antiviral drugs for HBV in a hospital increased from 5 698 200 yuan to 20 115 600 yuan during 2010-2014,and annual average rate of growth (AARG) of entecavir 76.37%. The consumption sum of ordinary interferon decreased year by year,with AARG of -20.30%. Besides DDDs of ordinary interferon declined year by year,DDDs of all antiviral drugs for HBV showed a trend of increased year by year,among which the increase of entecavir was the most obvious,being 1 366.30%from 2010 to 2014. The B/A value of lamivudine,telbivudine and or-dinary interferon were equal to or close to 1 for consecutive 5 years,and the number of patients was well synchronized with con-sumption sum. CONCLUSIONS:Nucleoside (acid) analogues has become an important method of HBV antiviral treatment,and the drugs should be selected reasonably according to the specific condition of patients in clinical treatment,in order to improve the safety,effectiveness and economy of treatment.

0.05); diaphragmatic tonicity were increased in FG groups ( P 0.05 ) . [ Conclusion ] FG has a protective effect on anoxic fatigued diaphragm.

Objective To investigate the intervention effect of Feikang Granules (FG) on airway remodeling and D-xylose excretory rate in pulmonosplenic asthenia rats with chronic obstructive pulmonary disease (COPD). Methods SPF SD rats were equally randomized into four groups:normal control group,COPD model control group,high-dose FG group,and low-dose FG group. The pulmonosplenic asthenia rats models with COPD were established by the way of smoking with cigarettes,repeated infusion of lipopolysaccharide in the airway and feeding with decoction of Folium Sennae.The general health state of rats was observed,and pathological changes of lung tissue were examined by the optical microscope. The wall thickness of small airway in rats was measured and the excretory rate of D-xylose was detected by bromoaniline method. Results Compared with the model control group,weight was increased,the pathological changes of pulmonary alveoli andbronchiole were relieved,small airway wall thickness became thin,and D-xylose excretory rate increased in high-dose and low-dose FG groups and the normal control group,the difference being significant (P