Chinese medicine health care industry is in a well developmenting atmosphere, though there are still some problems restricting the development, such as small scale of business assert and sales, lack of new products. These happened mainly due to people’s attitudes, such as thinking highly of treatment than prevention, few policies supporting and not perfect regulations. It is recommended to strengthen innovation at the premise of a combination of government and market leading, and establish appropriate safeguards.

Objective To investigate the Cardioprotective effects of sevoflurane postconditioning on surgery patients undergoing cardiopulmonary bypass with diabetes mellitus ,in order to provide theoretic basic for clinical practic. Methods 180 patients of undergoing cardiopulmonary bypass sugery were divided into 3 groups:A group:64 patients undergoing heart valve replacement with Type II diabetes. B group:64 patients Pa-tients undergoing heart valve replacement without diabetes ,the group A and B were treated by sevoflurane post-conditionging for 10 minutes before the end of cardiopulmonary bypass. C group:60 patients undergoing heart valve replacement without diabetes,no sevoflurane postconditionging;Three groups of patients detect perioperative tro-ponin T and Creatine Kinase Isoenzyme-MB ,observed and following up the occurrence of postoperative com-plications. Results CK-MB and cTnT were compared at 8 and 24 hours after operation:two biochemical indi-cators of group A and C at different time points after operation were significantly higher than those in group B (P < 0.05),With significant statistical difference , The number of patients with heart failure and malignant arrhythmia in group A and C was higher than group B(P < 0.05),Differences in 30 day mortality and other clinical data between the three groups were not statistically significant. Conclusion Sevoflurane postconditionging has significant myocardial protection effect for patients undergoing valve replacement surgery without diabetes , however ,the myocardial protective effect of patients who undergoing valve replacement surgery with diabetes was weakened.

TCM health-care service industry is in a rapid growth phase. It is important to stimulate consumption and boost domestic demand in health-care industry. Although TCM has unique advantages in health-care industry, lack of technical standards, industry standards and related policy have led to market chaos. Limited by inherent concept of TCM health-care services and the existing enterprise scale and level, health-care services cannot get sufficient play. This article analyzed current situation and main problems of TCM health-care service industry, and provided measures and suggestions for management system, industry access, and personnel quality.

Objective To: explore the efficacy and safety of interventional therapy for acute central pulmonary thromboembolism (PTE). Methods: Data of 72 patients with acute central PTE were retrospective analyzed. Interventional therapy of PTE were performed in all patients, then "one-stop" interventional therapy of deep venous thrombi of lower extremity were also performed in 65 patients. Complications during and after therapies were observed. Pulmonary artery pressure and D-dimer level were measured after interventional therapy and compared with those before treatment. The therapeutic effect was evaluated during follow-up. Results: No serious complication occurred. Heart rate arrhythmia and blood pressure rise during operation happened in 7 patients, blood leakage around thrombolytic catheter and subcutaneous ecchymosis at puncture point after operation were observed in 9 and 5 patients, respectively, all relieved after symptomatic treatment. Pulmonary artery pressure decreased significantly after interventional thrombectomy combined with catheter thrombolysis ([30.11±14.50]mmHg vs [40.22±17.58]mmHg, t=3.77, P<0.01), and D-dimer level also decreased significantly ([623.32±267.41]ng/ml vs [3 634.38±1 567.61]ng/ml, t=12.56, P<0.01) compared with those before treatment. The mean follow-up time was (15.92±5.22) months, and the total effective rate of interventional therapy of PTE was 97.22% (70/72). Complete thrombosis clearance or clearance rate of lower extremity higher than or equal to 95% (grade III) were observed in 61 patients (61/65, 93.85%) combined with PTE and deep venous thrombosis of lower extremities, while the rest 4 patients (4/65, 6.15%) had thrombosis clearance rate higher than or equal to 50% but lower than 95% (grade Ⅱ). Conclusion: Interventional therapy is safe and effective in treatment of acute central PTE, especially for patients with lower extremity deep venous thrombosis.

Objective To investigate the pattern of outpatients traffic,orchestra service resources,and optimize service provision,for a harmonized outpatient service.Methods A baseline survey was made at the outpatient department in 30 days(six hours per day,7:00-11:00,and 13:00-15:00).On such basis,data of the hospital's HIS system within the last five years were called into play for statistics analysis and simulation test,for the purpose of shift scheduling and resources allocation optimization.Results This study discovered each January-February as the valley of clinic visits and each July-August as the peak.52-week data analysis of a year found that the days of daily registrations between 4000-5000 are up to 163 days,those over 5000 are up to 86 days,of which Mondays with over 5000 registrations are up to 35 days.Each Monday is found to be a peak of outpatient visits,with significant drop during Saturdays and Sundays; daily registrations peak between 7:00-10:00 in the morning,while the traffic rises again during 13:00-14:00 in the afternoon,yet up to 26 ％of the morning peak only.Conclusion Statistics analysis of the outpatient service and emergency service at the outpatient department can help identify their patterns of operations,for effective improvement of service provision,alleviation of peak hour workload,shorten patient waiting time and better patient satisfaction.

Objective: To understand relationship between health literacy and health seeking behavior of undergraduate students in Shandong Province. Methods: A total of 1 460 undergraduate students from three universities in Shandong Province were selected through stratified random sampling method and received a questionnaire survey. Data were analyzed by one-way ANOVA, Chi-square test and regression analysis. Results: The proportion of students with basic health literacy was 64.4% (41.37±10.34). The proportion of students with basic knowledge and concept, healthy lifestyle and behavior, and basic skills was 49.6% (16.28±4.58), 70.3% (17.24±4.99) and 83.7% (7.85±1.58), respectively. About 28.1% of undergraduate students reported delay in seeking medical treatment, 71.9% reported prompt in seeking medical treatment, and 24.2% preferred to seek medical treatment in primary medical institutions, 45.5% secondary hospital and 30.3% tertiary hospital. Grade, major, the ability to gather and understand health information was the main factors affecting health literacy. Major and health information screening ability was the main factors affecting health seeking behavior. Grade, major, origin, the awareness and gathering of health information was the main factors affecting the choose of medical institutions(P<0.05). Basic knowledge and concept, basic skills and health literacy was positively correlated with the timing of health seeking behavior, while basic knowledge and concept, healthy lifestyle and behavior, and basic skills might give information on students’ preference on selecting a medical institution. Conclusion Attention should be paid to the cultivation of health information literacy. An integrated health education and health promotion model of "family-community-hospital-university" should be established.

Objective To investigate the preventive therapeutic effect and possible mechanism of single chain variable fragments chimeric protein (SD) of ovalbumin epitopes internalizing receptor DEC-205 antibody on food allergy in mice. Methods Mice were randomly divided to five groups (control, PBS, scFv DEC 100 μg, SD 50 μg, SD 100 μg) and treated for 24 hours before OVA administration. After challenge, the serum level of OVA-specific IgE, IgG1, IgG2a and IL-4 were detected by ELISA. Infiltration of eosinophils and mast cells in the jejunum was observed by HE staining and toluidine blue staining respectively. The bone marrow of tibia and femur was isolated and cultured to obtain immature dendritic cells(BMDCs), which were further treated with LPS (10 ng/mL), TSLP (50 ng/mL), scFv DEC protein (1000 ng/mL) and SD protein (10,100,1000)ng/mL for 24 hours, and the IL-10 level of supernatant was assayed by ELISA. Results Compared with PBS group, the number of SD-treated mice with diarrhea was markedly reduced. The difference in rectal temperature and the levels of serum OVA-specific IgE, IgG1, IgG2a and IL-4 decreased significantly after prophylactic administration of SD; The number of eosinophils and mast cells in jejunum also decreased significantly while the IL-10 level in the supernatant of BMDCs increased significantly after SD intervention. Conclusion SD mitigates experimental FA response by fosters the immune tolerance property of dendritic cells.
Mice ; Animals ; Ovalbumin ; Interleukin-10 ; Single-Chain Antibodies/genetics* ; Immunoglobulin E ; Epitopes/therapeutic use* ; Interleukin-4 ; Food Hypersensitivity/prevention & control* ; Immunoglobulin G ; Recombinant Fusion Proteins/genetics* ; Mice, Inbred BALB C ; Disease Models, Animal

As the P2X receptor family has become a research hotspot in recent years, the study on P2X₇ receptor has also received extensive attention. P2X₇ receptor (P2X₇R) is a dual-transmembrane cation-channel receptor, which is gated in vivo by adenosine triphosphate (ATP) and can be activated. Activated P2X₇ receptor can produce such effects as cationic channel opening, signal pathway activation, inflammatory mediator release and cell apoptosis. It plays an important role in the development of various tumors and inflammatory diseases. Studies have shown that the abnormal expression of P2X₇ receptor affects the occurrence and development of breast cancer by activating a series of signaling pathways, which is expected to become a new target for designing anti-breast cancer drugs. Other studies have shown that multiple microRNAs can promote the occurrence and development of breast cancer by regulating the expression of P2X₇ receptor gene. In this review, we reviewed the recent research advances of P2X₇ receptor and the relationship between breast cancer and its abnormal expression.

Objective To evaluate long term effect and related factors in patients with menorrhagia treated by microwave endometrial ablation(MEA).Methods Total of 334 women with menorrhagla were treated hy MEA,the range of age was from 29 to 59 years old.Among them,59 cases were complicated by adenomyosis.All the patients were followed up on the change of menstrual cycle.the amount of flow,improvement of anaemia and complication.Fifty-three women underwent outpatient diagnostic hysteroscopy,the biopsy tissue was taken from the endometrium for histopathological examination.The mean duration of follow-up was 64.7 months (3-96 months).Results The overall curative rate wag 91.3%(305/334),of which amenorrhea rate was 49.7%(166/334),menstruation reduction rate was 41.6%(139/334):71.1%(140/197) of the cases who previously had dysmenorrhea had relieved their pelvic pain and the satisfactory rate was 91.9%(307/334).Among patients＞40 years,92.9%(196/211) of operation effective rate,93.8% (198/211) of satisfactory rate and 64.9% (137/211) of amenorrhea rate were obtained.while patients≤40 years,88.6%(109/123) of operation effective rate,88.6%(109/123) of satisfactory rate and 23.6%(29/123) of amenorrhea rate were obtained.There was significant difierence in rate of operation effectiveness,satisfaction and amenorrhea (P＜0.05).Forty-two cases required subsequent treatment due to recurrence,of which 9 cases were given by secondary MEA and 33 cases (9.9%、33/334) underwent hysterectomy indicated by frequent menorrhagla,adenomyosis or leiomyoma.A completely destroyed endometrium was observed by hysteroscopy after MEA,pathologic characteristics of MEA showed two zones of necrotic tissue:the inner zone was coagulation necrosis and the outer zone of necrosis was hypocellular hyalinized myometrium.Conclusions MEA is the safe and efficacious management to treat menorrhagia.Incomplete removal of endometrium was the major reason resulting in postoperative recurrence.Young age and complicated with adenomysis were the main factors influencing long term clinical effect of MEA.

Objective To explore the epidemiologic and clinical features of hand, foot and mouth disease (HFMD) caused by Coxsackie virus A16 (CA16) in Suzhou from 2010 to 2014, and analyze the relationship between the SNPs of oligoadenylate synthetase 1 (OAS1) and HFMD caused by CA16 infection.MethodsThe clinical data of children diagnosed with HFMD caused by CA16 during 2010 and 2014 were collected. The epidemiological characteristics were analyzed. Among them, 167 cases were selected to make comparison of the clinical features with 166 cases of HFMD caused by EV71 infection in the same period. The genotyping ofOAS1 rs10774671 was detected by TaqMan probe technique in 167 cases of CA16 infection children, 166 cases of EV71 infection children with HFMD and 163 healthy children. The relationship between polymorphism of gene and infection of CA 16 was analyzed.ResultsA total of 9 016 children with HFMD were included. CA16 nucleic acid detected to be positive in 762 cases. The detection rate was 8.45%. CA16 infection was most commonly in summer. Children under 5 years old accounted for 94.62% infected. Compared with EV71 infected children, CA16 infected children had shorter fever time, severer oral herpes, ulcer, and rash in hand, foot and hip, lesser nervous system involvement, fewer cases of high lactate dehydrogenase, high C reactive protein, high IgM or IgG, and signiifcant changes in the percentage of CD3+, CD3+CD4+, CD3+CD8+ and CD3-CD19+ (P all?