Objective To promote rational drug use and assure the drug use in an effective and safe way by developing the monitoring role of clinical pharmacists in the adverse drug reaction .Methods The common reasons for adverse drug reaction were an-alyzed.The clinical pharmacists took advantage of their professional knowledge to deal with adverse drug reactions and reinforce the monitoring of the drug treatment.Results The clinical drug safety was ensured by reducing the adverse drug reaction incidence rate. Conclusion Pharmacy information exchange should be enhanced and the professional knowledge of clinical medical staff should be broadened to promote clinical rational drug use.