Objective To evaluate the efficacy and safety of chitosan in the repair of clinical surgery wounds.Methods The databases of Cochrane Controlled Trials Register (CCTR),Embase database,Medline database,PubMed database,CNKI database,WanFang database,VIP database and Chinese Biomedical Journal Library (CMCC) were retrieved with computer for collecting randomized controlled trials (RCT) about the repair clinical surgery wounds healing.Meta-analysis on all the data are carried out by RevMan 5.0 software.Results There were totally 16 trials and 3414 patients included.The results showed that the wound healing time ofchitosan was significantly shorter than that of the control group [WMD =-0.64,95％CI (-0.69～-0.59),P ＜ 0.000 01],and chitosan can better promote wound healing [RR =1.03,95％CI (1.01～1.04),P =0.0002].In experimental group,postoperativepain were reliever [WMD =-3.49,95％CI (-5.07～-1.91),P ＜ 0.0001],and postoperative infection were reduced [RR =0.49,95％CI (0.33～0.71),P =0.0002].Conclusion The existing evidences indicate that chitosan can shorten postoperative wound healing time,promote wound healing,relieve pain,and reduce infection.However,the study is limited by the quality of included literature,more clinical trials should be done to confirm the effective and safety.

Langerhans-cell histiocytosis (LCH), the most common histiocytic disorder, is a reactive clonal proliferation and accumulation of CD1a+ / CD207+ dendritic cells in inflammatory lesion, characterized by its strong heterogeneity and changeable complexity including apparent inflammation and tumor features, which should be redefined as an inflammatory myeloid neoplasia. Recent research has shown that LCH is the consequence of misguided myeloid differentiation on account of genomic aberrances in the RAS-RAF-MEK-ERK pathway. These gene inhibitors may present more curative effects for the treatment of LCH. With further prospective clinical trial, molecular targeted therapy may combine with or even replace the traditional surgery plus chemotherapy as the first-line regimen in LCH.

Objective To investigate the relationship between personality and social network profile-based information.Methods 438 college students were recruited,and Big five inventory NEO-FFI was applied to all subjects.The participants' Renren web profile information were recorded.Results ①Individuals with higher score of Extraversion had more friends (2.47 ± 0.29,2.34 ± 0.27,F =17.861,P =0.000),shared more (2.51 ± 0.56,2.32 ± 0.57,F =8.617,P =0.004),pasted more photographs (2.30 ± 0.51,2.14 ± 0.56,F =5.523,P =0.02).② There was a U shape correlation (t =2.258,P =0.024,t =2.115,P =0.035) between levels of neuroticism and numbers of blogs (0.66 ± 0.71) and photographs (1.92 ± 0.83).③There was no difference on numbers of friends (2.38 ± 0.31,2.39 ± 0.27,F =0.149,P =0.700) and e-gifts received (1.30 ± 0.52,1.26 ± 0.45,F =0.257,P=0.613) between participants of high and low levels of agreeableness.④ Individuals with higher scores in openness shared more with others(2.46 ± 0.57,2.29 ± 0.58,F =5.248,P =0.023).⑤ Individuals being more conscientious had more blogs(1.08 ±0.49,0.96 ±0.48,F=3.064,P=0.082).Conclusion There are significant differences about profile-based information among college students with different personality.

Objective To investigate the relationship between social network behaviors and personality.Methods Both questionnaires including self-reported Renren questionnaire and the simplified Chinese version of NEO five-factor inventory (NEO-FFI) were completed in university students (n =509).Results (1) Individuals with higher score of Extraversion used Renren applications more frequently,such as using Wall (2.26 ± 0.51,2.10±0.40,t=3.163,P=0.002),Status Update (2.58 ±0.71,2.33 ±0.62,t =3.268,P=0.001),Image (2.05±0.88,1.81 ±0.72,t=2.628,P=0.009),and Photo (2.17 ±0.49,1.96 ±0.33,t=4.409,P＜0.01).(2)Individuals with higher score of Openness of Experience were more likely to use Gift (2.01 ± 0.49,1.83 ± 0.59,t =2.870,P =0.005).(3) Individuals who were willing to use Blacklist (41.93 ± 4.41,43.07 ± 4.72,t =2.207,P =0.028) and who were willing to send private messages (42.23 ± 4.79,43.27 ± 4.55,t =2.476,P =0.014) have higher score of Agreeableness.(4) Individuals who checked messages more often had higher score of Conscientiousness (41.59 ± 6.33,40.72 ± 5.67,37.56 ± 8.33,F =7.170,P =0.001).(5) Individuals with higher score of Neuroticism were more likely to be dependent to Renren (2.91 ± 1.01,2.48 ± 1.02,t =3.815,P ＜0.01).Individuals who were more likely to express their emotions on SNS had higher score of Neuroticism (33.10 ± 6.78,32.19 ± 6.16,31.36 ± 5.77,F=3.594,P =0.010).Conclusion The data suggest that the usage of social networking sites are related to personality factors.Personality can be used to predict university students' social networking behaviors.

Objective To test the scientificity, practicability, feasibility, intelligibility, and acceptability of the Primary-Level Personnel Guiding Handbook for Schistosomiasis Control(probationary edition). Methods Twenty-seven county and village doctors were selected randomly from two schistosomiasis transmission uncontrolled counties in Jiangxi Province as pretest objects. The pretest was carried out with the focus group discussion. Results The proportions of pretest objects who considered handbook had scientificity, practicability, feasibility, intelligibility and acceptability were 59.26%, 85.19%,55.56%,51.85% and 92.59%, respectively, and the pretest objects had proposals and suggestions for modification. Conclusion According to the suggestion and proposal from the pretest objects, the handbook can be modified and published.

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.
Base Sequence ; DNA ; DNA Copy Number Variations ; DNA Replication ; DNA Replication Timing ; Genome* ; Genome, Human ; Genomic Instability ; Humans ; Mutagenesis ; Recombination, Genetic

The expression and activity of NF-κB in the synovium of collagen-induced arthritis (CIA)rats was detected in order to investigate the possible therapeutic effects of triptolide on rheumatoid arthritis (RA). The experimental Wistar rat model of CIA was set up by intradermal injection of emulsion of bovine collagen Ⅱ and the successful rate of setting-up models was evaluated by arthritis index (AI). Rats were grouped randomly into three groups: normal, model and treatment group.The expression of TNF-α and IL-6 in synovial fluid was detected by ELISA, and the expression and activity of NF-κB in synovium by immunohistochemistry method and by electrophoretic mobility shift assay (EMSA) respectively. As compared with normal group, the expression of TNF-α and IL-6 in synovia (P＜0.05), and the expression and activity of NF-κB (P＜0.05) in synovium were increased in model group. There was statistical difference in above-mentioned indexes between model group and treatment group. Triptolide may play a protective role in RA via downregulating the expression and activity of NF-κB in synovium.

Taking the fourth census of resources of traditional Chinese medicine (TCM) as the background,this paper was aimed to study the local wild Chinese herbal medicine resources,to promote the cultivation development of local TCM industry.Related data was acquired through the survey of sample area,quadrat fixed-point investigation,and in combination with the field survey Ta-Zha way.The results showed that through the survey of Baishan city of medicinal plants,and visiting survey of TCM materials planting technology.This paper recorded 158 species of Chinese medicinal herbs which are common in Baishan area,belonging to 62 families.And many wild Chinese medicinal resources are widely exploited.It was concluded that this study provided important theoretical basis for the development and utilization of medicinal resources of Baishan and practice cultivation experience for reference.

Objective:To explore the effects of dietary phosphate restriction education on serum phosphorus level, dietary phosphate intake and the knowledge of hyperphosphatemia in maintenance hemodialysis (MHD) patients.Methods:This study was a retrospective cohort study. A total of 116 hemodialysis patients in Huashan Hospital, Huadong Hospital and Tongji Hospital from October 2019 to December 2020 were enrolled in this study. They were divided into short-term group (84 cases) and long-term group (32 cases). The short-term group did not receive education or received education≤60 minutes. Meanwhile, the long-term group received education>60 minutes. Serum phosphorus level, dietary phosphate intake and knowledge of hyperphosphatemia were compared between the two groups after 4 weeks.Results:At baseline, age [64(56, 69) years old vs 65(60, 73) years old, Z=-1.493, P=0.136], the proportion of males [58.3%(49/84) vs 56.3%(18/32), χ2=0.041, P=0.839], dialysis age [55(26, 130) months vs 53(20, 132) months, Z=-0.062, P=0.951], body mass index, diabetes history, single-pool Kt/V, proportion of calctriol used, blood calcium, blood phosphorus, intact parathyroid hormone and dietary protein, dietary phosphorus and dietary phosphorus protein ratio had no statistical significance between short-term group and long-term group (all P>0.05). Adequate dietary phosphate restriction education reduced dietary phosphate intake [777.98(653.81, 943.16) mg/d vs 896.56(801.51, 1 015.51) mg/d, Z=-2.903, P=0.004], phosphate/protein ratio [13.16(11.52, 14.21) mg/g vs 15.27(13.31, 17.48) mg/g, Z=-3.929, P<0.001] and serum phosphorus level [(1.42±0.37) mmol/L vs (1.85±0.44) mmol/L, t=4.984, P<0.001]. Meanwhile, such education significantly improved achievement rate of serum phosphorus (62.5% vs 41.7%, χ2=4.034, P=0.045). In addition, patients in long-term group answered more questions correctly (completely correct plus partially correct) about the causes (93.8% vs 72.6%, χ2=6.120, P=0.013), poor prognosis (78.1% vs 52.4%, χ2=6.372, P=0.012) of hyperphosphatemia as well as the types of food with high phosphate (65.6% vs 52.4%, χ2=1.650, P=0.199). Conclusion:Adequate dietary phosphate restriction education reduces serum phosphorus level and dietary phosphate intake, and improves the knowledge of hyperphosphatemia in MHD patients.

Objective:To explore the risk factors of hypocalcemia and the correlation between calcium supplementation and clinical parameters after parathyroidectomy (PTX) in maintenance hemodialysis patients with secondary hyperparathyroidism (SHPT), and to analyze the effect of calcium supplementation after PTX on the long-term prognosis of patients.Methods:This study was a single-center retrospective study. The patients who underwent PTX in maintenance hemodialysis patients with SHPT in the Huashan Hospital affiliated to Fudan University from October 2014 to March 2021 were retrospectively enrolled. Total PTX with auto transplantation or total PTX alone were the surgical procedures. According to the postoperative requirement of calcium in the first week, the patients were divided into two groups: high calcium supplement (>16.05 g/week) group and low calcium supplement group (≤16.05 g/week). According to the average serum calcium level in the first week after operation, the patients were divided into hypocalcemia group (≤2.1 mmol/L) and non-hypocalcemia group (>2.1 mmol/L) and the differences of clinical parameters between the two groups were compared. The correlation between clinical parameters and the postoperative calcium requirement was examined through Pearson or Spearman correlation analysis. The influencing factors for hypocalcemia after PTX were examined through logistic regression analysis. The survival curve was made by Kaplan-Meier method, and the difference of cumulative survival rate between the two groups was compared by log-rank test.Results:A total of 98 maintenance hemodialysis patients with SHPT were enrolled. The levels of serum calcium, phosphorus, and intact parathyroid hormone (iPTH) after the operation decreased significantly than those of preoperation (all P<0.05). Multiple linear regression analysis showed age ( β=-0.160, P=0.030), iPTH ( β=0.004, P=0.025) and C-reactive protein ( β=0.186, P=0.011) were correlated with postoperative calcium requirement. Preoperative alkaline phosphatase ( OR=1.002, 95% CI 1.000-1.004, P=0.018) and hemoglobin ( OR=0.977, 95% CI 0.954-1.000, P=0.048) independently predicted the occurrence risk of postoperative hypocalcemia through multivariate logistic regression analysis. The recurrence rate of high calcium supplement group was higher than that of low calcium supplement group (10.26% vs 0, P=0.023) and there was no significant difference in all-cause mortality between the two groups (17.95% vs 5.08%, P=0.086). The recurrence rate between the hypocalcemia group and non-hypocalcemia group was no significantly different (8.3% vs 1.8%, P=0.451) and there was no significant difference in all cause mortality between the two groups (12.5% vs 12.7%, P=1.000). Kaplan-Meier survival curve showed that the cumulative survival rate between the two groups was no significantly different (log-rank test χ2=0.147, P=0.702). Conclusions:PTX is a safe and effective therapeutic method to reduce the level of iPTH and improve the metabolism of calcium and phosphorus in SHPT patients. Age, iPTH and C-reactive protein are correlated with the postoperative requirement of calcium in the first week. Preoperative alkaline phosphatase and hemoglobin are independent risk factors for postoperative hypocalcemia. Correcting preoperative electrolyte disorder, improving infection and anemia can reduce the incidence of hypocalcemia after PTX.