It is an important content for breaking the mechanism ofdrug-supplement-medicine that the com-pensation system of drug zero price rate should be improved in public hospitals. In this paper, we collect random sampling survey data of the implementation of zero-difference drug sales before and after which is performed in People's hospital and Traditional Chinese Medicine hospital in five counties( districts) of Chongqing city. Based on the data, the status and effects of pharmaceutical service Fee policy on the county-level public hospitals in Chongqing was evaluated by combining quantitative description with qualitative analysis in the research methods. The study shows that the compensation policy design of pharmaceutical service fee is reasonable in Chongqing city and its posi-tive effect is obvious. It has also an obvious effect on the reduction of the average outpatient and hospitalization drug expense;but it's not conducive to arouse the enthusiasm of public hospital deepening reform of the initiative because the actual compensation rate of pharmaceutical service fee is low, and the public hospital comprehensive compensa-tion mechanism and operation mechanism reform are lagging behind.

The mean plasma ANF level in 48 patients with diabetes mellitus was higher than that in normal subjects (875.2 ? 50.0vs542.5 ? 23.8ng/L). And ANF levels were positively correlated with serum insulin and the dimension ofleft atria. There was some relationship between ANF and cardiac autonomic function score, but it's not statistically significant. No significant correlation was observed between plasma ANF and the duration of diabetes, urine sodium, blood glucose or HbA1C levels. The levels of plasma ANF in 9 patients with cardiac complication and 6 patients with diabetic nephro-pathy were both higher than that in patients without any obvious complication. The decrease of plasma ANF in OGTT was due to a fall of extracellular volume, and had little relation with the changes of serum insulin.

The paper analyzes the operation of the public health administration system under normal circumstances and the dilemmas the system faces in case of a crisis, sums up the new features presented by e-mergent public health crises under the new circumstances: rapid spread, multiplier amplification and superimposed resonance, and discusses issues related to the establishment of an emergency response system. It argues that in order to meet the universal demands in preventing and controlling modern crises, it is imperative for the existing public health administration system to transform into the structurally differentiated and greatly enlarged emergency response system; and it is also imperative to establish the three subsystems of emergency decision-making, emergency mobilization and operations, and control and correction so as to improve and strengthen the functions of the original system.

Knowledge management, a completely new way of thinking and mode of management in the knowledge economy era, is of great practical significance to modern hospital management. Knowledge management in modern hospitals ought to be conducted in accordance with the demands for organizational knowledge and knowledge-based organizations, with sound combination of hardware and software and harmony between people and their surroundings. Efforts ought to be made in achieving innovations and breakthroughs in the three major aspects of knowledge environment, knowledge system and knowledge organization so as to meet in a calm manner the opportunities and challenges that come with knowledge economy.

Starting from the definition of public health, the paper analyzes the general properties of public health products as public products and the special properties of public health products as health products and discusses the structures and features of public health products in both supply and demand models. It also puts forward some suggestions for realizing balance between the supply and demand of public health products: ①establishing a parallel operational mechanism; ②creating “complete information” linking supply and demand; and ③ bringing about “entire rationale” to public behavior.

Purpose: This study is to observe the therapeutic effect of puncturing acupoints Dazhui (GV 14), Fengchi (GB 20), Jiaji (Ex-B 2), Waiguan (TE 5), Qiuxu (GB 40) and Zhaohai (KI 6) on vascular headache. Methods: 68 cases of vascular headache were divided into treatment group including 38 cases and control group including 30 cases. The patients in treatment group were treated by puncturing Dazhui (GV 14), Fengchi (GB 20), Jiaji C26 (Ex-B 2),Waiguan (TE 5), Qiuxu (GB 40) through Zhaohai (KI 6) and patients in control group were asked to take Pizotifen orally. Results: After 2 courses of treatments, 35 cases got effect in treatment group, and 22 cases got effect in control group, the therapeutic effect in treatment group was superior to that in control group (P＜ 0.05). Conclusions: Puncturing Dazhui (GV 14), Fengchi (GB 20), Jiaji C26(Ex-B 2), Waiguan (TE 5), Qiuxu (GB 40) and Zhaohai (KI 6)is effective for the vascular headache.

Great improvement has been made in the 5-year survival of patients with osteosarcoma due to application of novel chemo-agent and progression in surgical techniques. However, the treatment outcome of osteosarcoma was bottlenecked by drug resistance and immuno-escape mechanism. Recent studies showed that some osteosarcoma cells possess the characteristic of tumor stem cells: capable of self-renewal and extensive proliferation. Meanwhile, SP cells, isolated from osteosarcoma cells, have high expression of ABCG2 and can form tumor in NOD/SCID mice, indicating that the drug resistance of osteosarcoma cells might be related to SP cells. Studies on the biomarkers of tumor stem cells and decrease of ABCG2 expression may contribute to the treatment outcome of osteosarcoma. Moreover, research on active and passive immunotherapy and Src protein tyrosine-kinase targeted therapy may provide new pathways for treatment of osteosarcoma.

OBJECTIVE:To discuss the causes and related treatment strategies of artificially high drug prices. METHODS:The causes of artificially high drug prices were analyzed from drug price formation,distribution and trading,drug use in medical institutions and other aspects,in order to sort out the overall plan and treatment strategies of artificially high drug prices. RESULTS& CONCLUSIONS:Artificially high drug prices are resulted from not sound pricing mechanism,numerous circulation links,im-perfect procurement system,“drug maintaining medicine”mechanism of medical institutions and other factors. It is suggested to solve artificially high drug prices from perfecting drug market price formation mechanism,promoting circulation reform,improving centralized purchasing trading mechanism;at the same time,accelerating the reform of medicare payment system,deepening the re-form of public medical institutions operating mechanism and perfecting supervision laws and regulations so as to gradually improve the drug price administration system and realize reasonable drug pricing.

The article introduced and stressed laryngeal mask airway(LMA)'s invention and development,structure and classification,history and current situation of the applications of LMA in neonatal resuscitation,placement methods,recommendation of international guidelines for neonatal resuscitation on LMA,advantage and disadvantage when LMA versus bag-mask and endotracheal intubation ventilation for neonatal resuscitation,LMA extensions of research in neonate,and significance and prospects of its application in China.