1.Early intervention of atherosclerosis in type 2 diabetic patients with microalbuminuria
Jian-Ming HOU ; Qing-Ming LIN ; Jian-Wei LI ; Wei-Te ZHUANG ; Gang CHEN ; Chao-Qun ZHANG ; Li-Xiang LIN ;
Chinese Journal of Endocrinology and Metabolism 2000;0(06):-
A total of 160 type 2 diabetic patients were divided into microalbuminuria(42 cases)and normoalbuminuria(118 cases)groups.Multivariate analysis demonstrated that the presence of microalbuminuria was independently associated with brachial-ankle pulse wave velocity(baPWV)and intima-media thickness(both P
2.Gene expression profiling of skeletal muscle in type 2 diabetic rats
Jun-Ping WEN ; Li-Xiang LIN ; Gang CHEN ; Wei-Te ZHUANG ; Lian-Tao LI ; Miao LIN ; Qing-Ming LIN ;
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
Differences in gene expressions were compared by cDNA microarray in skeletal muscle of type 2 diabetic rats and normal rats.In diabetic rats,157 genes were down-regulated and 100 genes up-regulated. Some of these genes were related to insulin resistance,glucose and lipid metabolism.
3.Prevalence and risk factors of peripheral arterial disease in diabetic patients over 50 years old in China.
Heng GUAN ; Yong-Jun LI ; Zhang-Rong XU ; Guang-Wei LI ; Xiao-Hui GUO ; Zhi-Min LIU ; Da-Jin ZOU ; Hui-Li XING ; Wei LIU ; Zheng-Yan SHENG ; Hao-Ming TIAN ; Da-Long ZHU ; De-Min YU ; Wei-Te ZHUANG ; Lu-Lu CHEN ; Jian-Ping WENG
Chinese Medical Sciences Journal 2007;22(2):83-88
OBJECTIVETo investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD.
METHODSIn total 1,397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China.
RESULTSMean patient age was 63.7 +/- 8.2 years and mean duration of diabetes mellitus was 9.39 +/- 7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI < 0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin A1c, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI.
CONCLUSIONSPAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors.
Aged ; China ; epidemiology ; Diabetic Angiopathies ; epidemiology ; Female ; Humans ; Male ; Middle Aged ; Peripheral Vascular Diseases ; epidemiology ; Prevalence ; Risk Factors ; Urban Population ; statistics & numerical data
Result Analysis
Print
Save
E-mail