Objective:To compare the clinical factors and physical parameters between 3-fields and 4-field 3-dimensional con-formal radiotherapy(3DCRT)for mid-thoracic or upper-thoracic esophageal carcinoma.Methods:Patients with mid-thoracic or upper-thoracic esophageal carcinoma were chosen at random and treated with 3DCRT.Contouring and treatment planning were performed with VARIAN Eclipse treatment planning system(TPS).The target volume was determined according to guidelines from ICRU Report No.50.The three-beams treating plan and the four-beams treating plan were performed and a 8mm isotropic mar-gin was added for the planning target volume(PTV)in beam setting.The different plans were evaluated with dose volume histograms(DVH)in terms of dose coverage of PTV and protection of organs at risk(OAR).The prescribed dose was 60 Gy/30 F to the PTV.Results:There was no significant difference in the dose coverage to PTV and the explored dose to spinal cord with the two model of 3DCRT.When the three-beams treating plan was compared with four-beams treating plan,lungs V20 and V30 were significantly better,and at the same time lungs V5 was higher.Conclusions:3-fields 3DCRT is better than 4-fields 3DCRT with lower lungs V20 and V30 so as to prevent acute radial injury of lungs in radiotherapy of mid-thoracic or upper-thoracic esophageal carcinoma.

Objective To study the effects of laparoscopic radical gastrectomy for gastric cancer on serum inflammatory cytokines and intestinal barrier function in patients.Methods Retrospective analysis was used to investigate a total of one hundred and forty gastric cancer patients in Ezhou Central Hospital from January 2014 to September 2016,including 66 cases with laparoscopic radical gastrectomy (laparoscopic group) and 74 cases with traditional open radical gastrectomy (traditional group),the perioperative indexes,inflammatory factors and intestinal barrier function of the two groups were compared.Results In the laparoscopic group,the amount of bleeding loss in the laparoscopic group ((86.8 ± 15.2) ml),the incision length ((6.2 ± 1.4) cm),the first anal exhaust time ((3.0 ± 0.6) d),the fluid diet time ((4.6 ± 0.9) d),the postoperative hospitalization ((8.8 ± 1.7) d) were all lower than those in the traditional group ((158.2±25.0) ml,(16.3±2.7) cm,(3.6±0.7) d,(5.1±0.8) d,(10.3±2.5) d),the differences were statistically significant (P=0.000,0.000,0.000,0.014,0.001);the operation time of the traditional group was (196.5±27.8) min,the number of lymph nodes was (21.6±2.8),compared with those in the laparoscopic group ((192.5±30.3) min,(22.0±3.1),P=0.421,0.137).The levels of WBC,IL-6,CRP,TNF-ɑ,COR,plasma D-lactic acid and diamine oxidase in the laparoscopic group were lower than those in the traditional group (P=0.000).Conclusion The effect of laparoscopic radical gastrectomy on serum inflammatory cytokines and intestinal barrier function in patients is not obvious.

The diagnosis of the hip diseases and the judgment of the treatment are based on the measurement parameters with X-rays that mainly defined as anterposterior pelvis radiographs of the hip joint.The data of the measurement changes in different ages due to the growth and development of children's bodies.There are varies of parameters attempt to improve the evaluation of the hip joint.The review focuses on the Chinese and English literature since 1930s,and summarizes the introduction of the history and current condition,modified progress of methods and data analysis of measuring results.

Drug treatment is one of the most important parts in t he therapeutics of periodontal disease. This review discusses the purpose, signifi cance、pharmacological mechanisms, administration methods and announcements of c linic medication in periodontal disease and summarized clinical commonused drug as well as the reseach progress in drug therapeutics of periodontal disease.

Objective: To evaluate the effectiveness of minocycline at subantimicrobial dosage in the treatment of experimentally induced periodontitis in rats.Methods: Periodontitis was induced by silk ligature technique on 4 second molars in each of 16 adult male Sprague-Dawley rats and the animals were fed with 100 g/L sucrose drink. The rats were divided into 2 groups: (1)periodontitis group without treatment;(2)treatment group, the rats with periodontitis were treated by systemic administration of minocycline at 5 mg/(kg?d).Another 8 normal rats were used as the controls. Assessment was carried out at day 28 and 56 using a number of different visual, histological and ultrastructure approaches.Visual assessment included tooth mobility(TM), gingival index(GI), and alveolar bone loss. Histological examination included monocyte effusion,resorption lacunae with osteoclasts and percentage of the periodontal collagen.The collected data were statistically analyzed using variance test.Results: Systemic administration of minocycline at subantimicrobial dosage can significantly reduce GI, TM, resorption lacunae with osteoclasts and alveolar bone loss either at day 28 or at day 56; significantly inhibited monocyte effusion and the collagen degradation in the periodontium at day 56 in rats with periodontitis. Conclusion: Minocycline at subantimicrobial dosage may decrease alveolar bone loss and osteoclasts formation in periodontium with periodontitis.

B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders. In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).

Cerebral Cortex ; growth & development ; physiology ; Evoked Potentials, Visual ; physiology ; Humans ; Infant, Newborn ; Infant, Premature ; growth & development ; Sensory Thresholds ; physiology ; Vision, Ocular ; physiology ; Visual Acuity ; physiology ; Visual Perception ; physiology

Adult ; Ear Canal ; pathology ; Ear Neoplasms ; Female ; Humans ; Neurofibromatoses

Objective:To investigate the preventive effect of nalmefene on sufentanil-induced cough in the patients with general anesthesia. Methods:Eighty patients with general anesthesia were randomly divided into the control group and the nalmefene group. The nalmefene group was intravenously given 0. 25μg·kg-1 hydrochloric acid natrium nalmefene 5 minutes before the induction, and physiological saline with the same capacity was given in the control group. Cough number and intensity in one minute after the injection of nalmefene were observed, and the changes of hemodynamic indices such as the blood pressure, heart rate and pulse oxygen satura-tion before the anesthesia induction (T0), 1min after sufentanil injection (T1) and after the intubation (T2) were observed and com-pared between the groups. Results:The incidence rate of cough was 37. 5% in the control group and 0% in the nalmefene group, and the incidence rate and strength of cough in nalmefene group were both lower than those in the control group (P<0. 05). The hemody-namic parameters at T1 showed notable changes when compared with those at T0 in the control group (P<0. 05), and had significant differences when compared with those in the nalmefene group (P<0. 05), and at T2, all the parameters recovered to the levels at T0. The parameters in the nalmefene group were much more steady than those in the control group (P>0. 05). Conclusion:Pretreatment with hydrochloric acid natrium nalmefene can prevent sufentanil-induced cough response during the induction of anesthesia without weakening the inhibitory effect of sufentanil on intubation response.

The source, super-antioxidant activity, biological safety and application in medicine, health food and animal feed industry of natural astaxanthin are reviewed in present paper. The industrialization prospect of astaxanthin in China is also proposed.