China ; History, 20th Century ; Humans ; Integrative Medicine ; history ; Medical Oncology ; history ; Physicians ; Portraits as Topic

Objective:To compare clinical characteristics of acute and chronic central serous chorioretinopathy (CSC).Methods:41 patients with CSC in the First Affiliated Hospital of Soochow University were studied, according to the course, they were divided into acute central serous chorioretinopathy group (A group, 29 eyes of 29 cases) and chronic central serous chorioretinopathy group (B group, 12 eyes of 12 cases). All patients underwent the best corrected visual acuity (BCVA), subretinal fluid thickness (SRF) and subfoveal choroidal thickness (SFCT) examination. The imaging characteristics of fundus fluorescein angiography (FFA) and optical coherence tomography angiography (OCTA) were compared between the two groups.Results:The BCVA, SRF and SFCT in A group were higher than those in B group ( P<0.05). FFA in group A showed that the leakage of ink diffusion or smoke type fluorescein leakage. FFA in group B showed that the fluorescein leakage was single or multiple in macular area, and atrophy of retinal pigment epithelium (RPE) cells was observed. OCTA of group A showed that the choroidal capillary layer showed high blood flow signal, low blood flow signal around the outside, or coarse granular high signal, and no choroidal neovascularization (CNV) was found. OCTA in group B showed that the image of choroidal capillary layer was similar to that of group A, but in group B, 2 eyes (2/12) had CNV with obvious morphology. Conclusions:Clinical characteristics of acute and chronic central serous chorioretinopathy are different. OCTA has definite application value in follow-up and detection of CNV.

AIM To develop a comparative method for studying on the HPLC/UV/MS fingerprints of triterpene acid in the leaves and the seeds of Lagerstroemia specious L. METHODS Separation was performed on LunaC_ 18 (2.6 mm?250 mm, 5 ?)analytical column, The mobile phase was composed of acetonitrile and 0.1 % formic acid as gradient eluent. The flow rate was 1.0 ml?min -1 . RESULTS Both of corosolic acid and maslinic acid existed in the leaves and the seeds of Lagerstroemia specious L. Ursolic acid existed in the leaves and the oleanolic acid contained in the seeds of Lagerstroemia speciouswere L. CONCLUSION The method can be used for quality control of the leaves and the seeds of Lagerstroemia specious L.

OBJECTIVE To investigate the resistance of Staphylococcus to erythromycin and clindamycin and detect the percentage and gene for inducible resistance in Tai'an.METHODS The susceptibilities of Staphylococcus to erythromycin and clindamycin were examined by Kirby-Bauer disc agar diffusion test and the inducible erythromycin resistance to clindamycin was checked by D-test according to the standards of NCCLS,and the resistance genes msrA,Vgb,sat4,ermA,ermB and ermC were detected by using PCR technology.RESULTS Among the 326 strains,162(44.12%)were all resistant to erythromycin and clindamycin;68(20.86%)were resistant to erythromycin and sensitive to clindamycin but they were positive in D-test;42(12.88%)were resistant to erythromycin and sensitive to clindamycin but they were negative in D-test.The rates of inducible resistance of MRSA,MSSA,MRCNS and MSCNS to clindamycin were 40.00%,56.25%,63.38% and 66.67%,respectively among the Staphylococcus which were resistant to erythromycin and sensitive to clindamycin.The gene ermC was the main one for inducible erythromycin resistance to clindamycin.The percentage of gene ermC was 85.29% and that of ermC and sat4 either was 7.35%;all the others were negative.CONCLUSIONS The rate of inducible erythromycin resistance to clindamycin in our area is relatively high,and D-test in clinical microbiology laboratory should be done so that the physicians can select the reasonable MLSB antimicrobial agents.

OBJECTIVE To investigate the evolution of drug-resistance of Staphylococcus aureus in children in Hubei tertiary level hospitals during four years and provide the evidence for clinically reasonable use of antibiotics.METHODS The summary data of drug sensitivity in clinical isolates of meticillin-resistant S.aureus(MRSA) and meticillin-sensitive S.aureus(MSSA) in children in Hubei tertiary level hospitals from 2004 to 2007 were investigated retrospectively and the results were analyzed statistically.RESULTS The tendency of infections with MRSA upgraded yearly during four years(5.7%→10.7%→40.8%→46.9%);the resistance rates of MRSA to various antibiotics were all higher than that of MSSA.The vancomycin-resistant S.aureus had not been detected.CONCLUSIONS The drug-resistance status of SA in Hubei is still very serious.We should adopt effective measurement to control the occurring and epidemic outbreak in combination with children physiological characteristic.

[Objective] Through a meta-analysis to compare the effectiveness and safety of traditional Chinese medicine and western medicine in the treat-ment of chronic atrophic gastritis(CAG) with dysplasia . [Methods] Randomized clinical trials(RCTs) which compared traditional Chinese medicine and western medicine for chronic atrophic gastritis with dysplasia in PubMed, Cochrane library, WanFang and CNKI were searched. The patients which were analyzed were divided into two groups: western medicine and traditional Chinese medicine.Statistical heterogeneity between trials was evaluated by RevMan5.0. Heterogeneity of the included articles was tested and used to select proper effective model for calculation.Publication bias was investigated through visual inspection of funnel plots and Egger's regression model.[Results] 6 RCTs including 632 patients were analyzed. The total odd ratios(OR) of clinical symptoms,gastroscope symptoms,pathological symptoms by traditional Chinese medicine were higher than western medicine, the OR values were 3.40(95%CI:2.18~5.31,P<0.01),4.14(95%CI:2.37~7.20,P<0.01),2.94(95%CI:1.77~4.90,P<0.01),3.71(95%CI:2.29~6.02,P<0.01),4.41(95%CI:2.75~7.07,P<0.01),5.21 (95%CI:3.65~7.43,P<0.01). Inspection of the funnel plots for al outcome measures did not reveal evidence of publication bias( P=0.81, 0.41, 0.29, 0.88, 0.44, 0.82, respectively).[Conclusions] The treatment of chronic atrophic gastritis with dysplasia by traditional Chinese medicine can improve the excel ent response rate, overal response rate of clinical symptoms,gastroscope symptoms,pathological symptoms better than its purely western medicine treatment efficacy.

Objective To understand the Wuxi area index detection of infectious blood donors in the blood situation,in order to take targeted measures to block the blood-borne diseases.Methods From 2005 to 2012,Wuxi area (not including county, district)blood donation blood samples 329 254 (person)copies of the test results were retrospectively analyzed.Results 8 years,Wuxi unpaid donors HBsAg,anti-HCV,anti-HIV,and anti-TP four tested positive rates were 0.587%,0.452%, 0.212% and 0.509%,the total positive rate was 1.76%.Different years of anti-HCV,anti-HIV and anti-TP positive rate difference was statistically significant (χ2= 40.74~138.24,P<0.01).From 2011 to 2012 HBsAg positive rate was signifi-cantly increased,and compared with the previous year,difference was statistically significant (χ2=47.56,52.34,P<0.01), while four the number of positive indicators of infection in different sex,age and occupation with different proportions of dis-tribution.Conclusion The positive rate of most indicators declined year by year,but there was still an upward trend in indi-vidual proj ects.Should further improve the different groups of scientific blood donation advocacy work to ensure blood safe-ty.

The physicochemical properties and functional activities of chitooligosaccharides are more superior than chitin and chitosan, so chitooligosaccharides becomes a new developing kind of functional oligosaccharides worldwide in recent years. Research development of the physiological activities of chitooligosaccharides such as antibacterial activity, antitumor activity, protective effect on bacterial infection in vivo , regulation of plant physiology, proliferation of bifidobacteria and anti-mutagenic activity was reported in China and a-broad, meanwhile, application prospect were forecasted as well in the paper.

Objective To study the relationship between the serum level of cholinesterase (CHE) and patient's clinical characteristics and serum levels of lactic dehydrogenate(LDH) and β2-microglobulin (β2-MG) in non-Hodgkin lymphoma(NHL) patients. Methods The levels of CHE, LDH, β2-MG were detected with rate method and immunoassay respectively in 74 patients, and then these patients were divided into low (38 patients) and high level groups (36 patients) according to the serum CHE levels, compared with clinical characteristics and serum levels of LDH and β2-MG between the two groups. Results There were a significant difference in serum levels of CHE, LDH, β2-MG between the low and the high CHE level group [(3714.2 ±1207.1) U/L, (435.7±364.4) U/L, (4.3±2.9) mg/L; (7898.2± 1550.5) U/L, (247.4±134.8) U/L, (2.7±1.2) mg/L, respectively] (t =10.510, P =0.000; t =2.969, P =0.005; t =3.043, P =0.004, respectively). There were no statically significance in age, pathology type, leukocyte and platelet between the low and high serum CHE level groups (t =0.166, P =0.868; x2 =0.751, P=0.386; t =1.626, P=0.111; t =1.987, P=0.056, respectively). Patients with low CHE level group were mostly in Ann Arbor Ⅲ-Ⅳ period (x2 =9.394, P =0.024) and mostly male patients compared with the high CHE level group patients (x2 =5.432, P =0.020). The quantity of hemoglobin in the low CHE level group(97.6±25.8) g/L were lower than that of the high level group (113.4±15.2) g/L (t = 3.230, P =0.002). Conclusion The low CHE level was not correlated with age, pathology type, leukocyte and platelet, but was related with male, Ann Arbor Ⅲ-Ⅳ period, anemia, and higher expression of LDH, β2-MG.

Objective To observe the influence of low epidural anesthesia on heart rate variability (HRV) and blood pressure,heart rate in elderly hypertensive patients.Methods 125 patients who were adopted routine selective pelvic cavity operation or lower limb operation were divided into the two groups,the observation group(56 cases) complicate with hypertension,control group (69 cases)with normal blood pressure.The heart rate,blood pressure and low frequency,high frequency of HRV before and 5min,15min,45min after anesthesia were monitored and compared.Results Before operation and 5,15,45 min after anesthesia,the systolic blood pressure were (150.2 ±12.4)mmHg,(142.6 ±12.9)mmHg,(127.6 ±12.9)mmHg,(123.7 ±11.3)mmHg,diastolic blood pressure were(84.2 ±12.3)mmHg,(75.3 ±10.4)mmHg,(73.7 ±8.61)mmHg,(71.7 ±7.3)mmHg,heart rates were (88.4 ±11.3)times/min,(82.3 ±9.1)times/min,(78.4 ±10.5)times/min,(77.5 ±10.5)times/min,low frequency ofHRV were (87.5 ±23.7)Hz,(76.4 ±22.2)Hz,(55.4 ±22.1)Hz,(62.4 ±21.3)Hz,high frequency of HRV were(50.2 ±22.2)Hz,(32.3 ±16.7)Hz,(29.5 ±18.3)Hz,(26.3 ±18.4)Hz in the observation group;The systolicblood pressure were (133.6 ±11.4)mmHg,(123.1 ±9.5)mmHg,(121.6 ±10.1)mmHg,(120.3 ±16.3)mmHg,diastolic blood pressure were (77.3 ±11.8)mmHg,(71.4 ±10.5)mmHg,(70.4 ±10.2)mmHg,(71.2 ±8.6)mmHg,heart rate were (85.8 ±10.7 )times/min,(85.8 ±10.7 )times/min,(84.3 ±11.4)times/min,(84.5 ±11.9)times/min,low frequency of HRV were (69.1 ±20.7)Hz,(59.6 ±22.1)Hz,(45.7 ±26.8)Hz,(56.3 ±17.4)Hz,high frequency of HRV were (39.5 ±20.3)Hz,(34.6 ±18.9)Hz,(40.6 ±21.7)Hz,(41.1 ±18.1)Hzin the control group;The systolic blood pressure and diastolic blood pressure in the observation group after anesthesiawere lower than those before operation(systolic blood pressure:t =4.622,5.361,5.732,all P <0.05;diastolic bloodpressure:t =4.778,5.246,5.835,all P <0.05),The systolic blood pressure and diastolic blood pressure in the control group after anesthesia were lower than those before operation(systolic blood pressure:t =3.135,3.526,3.778,allP <0.05;diastolic blood pressure:t =3.636,3.578,3.467,all P <0.05),The systolic blood pressure and diastolicblood pressure in the observation group declined by a larger margin than those in the control group(t =3.782,3.825,3.562,all P <0.05),the heart rate after anesthesia were lower than those before operation both groups(observationgroup:t =4.613,5.724,6.146,all P <0.05;control group:t =3.143,3.672,3.572,all P <0.05),the heart rate inthe observation group declined by a larger margin than those in the control group(t =3.052,3.462,3.782,all P <0.05),low frequency of HRV and high frequency of HRV in the observation group after anesthesia were lower thanthose before operation(low frequency of HRV:t =4.144,5.156,4.714,all P <0.05;high frequency of HRV:t =4.614,4.352,4.667,all P <0.05),low frequency of HRV and high frequency of HRV in the control group after anesthesia were lower than those before operation(low frequency of HRV:t =2.625,3.622,3.725,all P <0.05;highfrequency of HRV:t =3.273,3.605,3.726,all P <0.05),low frequency of HRV and high frequency of HRV in theobservation group declined by a larger margin than those in the control group(low frequency of HRV:t =3.578,3.061,3.136,all P <0.05;high frequency of HRV:t =3.851,3.414,3.684,all P <0.05).Conclusion Low epidural anesthesia would exert huge impact to the autonomic nervous system of elderly hypertensive patients.