Neck lumbar traction bed is through the computer control motor and hydraulic transmission device, implementation of traditional Chinese medicine traction, Angle rotation and manual reduction action of a device, etc. Saving time and effort can well meet the needs of the treatment on lumbar disease. Based on the failure phenomenon of traction bed hydraulic transmission device, the composition and working principle analysis of the hydraulic system, concluded that failure of the hydraulic transmission device is due to the pressure gauge damaged or blocked between the tubing and the overflow valve, which allows users to quickly troubleshoot.

With the improvement of living standard, the requirement of artificial joint material is ever increasing. The development of meted artificial joint, high polymer artificial joint and ceramic-made artificial joint, which are widely used in joint replacement, are introduced. Advantages and disadvantages of these materials are discussed, as well as the required improvement to these three materials. Development on metal-to-metal hip resurfacing arthroplasty and its clinical application is introduced. Now that no material with good biocompatibility, good biomechanical compatibility, good biological aasociativity and satisfied life-span has yet been found, compound material artificial joint may be the focus of the research in future.

Schistosome is covered by a living syncytium, called tegument, which plays important role in nutrient uptake and immune evasion.Recently, tegumental proteomic research identified lots of proteins, of which there may be potential targets for diagnosis, drugs and vaccines.

Intraperitoneal. injection of the essential oils of Asarum himalaicum and A. heterotropides var. mand shuricum can inhibit the proliferation of granuloma induced by implantation of cotton pellets in rats, and change the distribution of Copper and Zinc,the two necessary trace elements for rats,in rat serum and liver.They reduce concentration of Zinc but increase that of Copper in the serum,while elevate the concentration of Zinc but reduce that of Copper in liver. The oil of A. himalaicum collected from Ningxia Region showed even stronger effects.

Being a part of the microcirculatoty system,retinal microvasculature may have similar morphology change as cardio-and cerebro-microvasculature under the pathological conditions.Although no study has proved that there exists causal relationship between retinal microvasculature change and cardiovascular diseases (CVD) , realizing their connection is extremely vital for ophthalmologists to evaluate the status of the systemic microcirculation, predict the occurrence of CVD, and proceed primary prevention by visible information of retinal microvascular alteration.In addition,for the patients suffering from retinal vascular occlusion,especially those with undiagnosed systemic diseases like CVD,ignoring systemic examinations may delay proper treatment and lead to the consequences of ill health.In conclusion, ophthalmologists should recognize the association of retinal microvasculature changes with systemic vascular diseases and provide useful information for primary prevention and early diagnosis and treatment of systemic vascular diseases.

Objective To explore the dynamic variation of inhibin B(INHB)in patients with polycystic ovary syndrome(PCOS)in the course of controlled ovarian stimulation(COS).To analyze the correlation between the increment of serum INHB and the dosage of Gn and the number of oocytes in PCOS.Methods Immunohistochemistry was performed to assess the level of INHB in 90 patients with PCOS and 20 normal childbearing period women in the course of COS.We collected the blood samples of all the patients on the third day of the menstrual(day 3),the day start to administrate exogenous gonadotropin(Gn day),five days later of the Gn day(Gn5 day)and the day of HCG injection(HCG day),respectively.Results Compared with the control group,the serum level of INHB was higher in the PCOS group,regardless day3,Gn day,Gn5 day and HCG day,the difference was statistically significant(P <0.01).In the course of COS,the level of serum INHB in the tow groups was increased.In the PCOS group,the greater the ΔINHB(the growth of the serum level of INHB on Gn5 day),the less of the Gn dosage,and the more number of oocytes retrieved.Conclusion In the process of COS,the serum level of INHB has obvious change.The serum levels of INHB reduce after pituitary down -regulation,then increase after COS.

BACKGROUND:Effects of pedicle screw placement on fracture reduction or stability of mechanics are influenced by various factors. Pedicle screw fixation failure is mainly due to fracture, loosening and fatigue. The main influential factors for biomechanical stability of pedicle screw are length and diameter. The research on the depth is less. OBJECTIVE:To analyze the relationship between pedicle screw placement depth of vertebral body and the fixed stability based on the biomechanics. METHODS: A model of single vertebral compression fractures was made in 15 pigs aged 5 months on L2 vertebral specimen. According to the length of anteroposterior diameter, vertebral pedicle screws were inserted in different depths (80%, 90% and 100% of anteroposterior diameter). After fixation, specimens were loaded 10 000 times at the frequency of 0.5 Hz (340±125) N on a WDT-10KN type universal material testing machine. Ranges of motion at anteflexion, backward extension, left bending and right bending and the maximum axial pulout force were measured in each group, and the difference of intergroup data was compared. RESULTS AND CONCLUSION:(1) Ranges of motion at anteflexion, backward extension, left bending and right bending in each group were significantly smaler in the 100% and 90% groups than in the 80% group (P < 0.05), and above parameters were smaler in the 100% group than in the 90% group (P< 0.05). (2) After fatigue test, the maximum axial pulout force was significantly larger in the 100% and 90% groups than in the 80% group (P< 0.05), and above data were significantly larger in the 100% group than in the 90% group (P < 0.05). (3) Results indicate that the depth into the vertebral body was significantly associated with its fixed stability. The deeper the depth into the vertebral body, the stronger the vertebral stability was: 100% group > 90% group > 80% group.

Objective To investigate the effects of compound danshen dripping pill (CDDP) on carotid intima￣media thickness (CIMT) and cardiac function in patients newly diagnosed as hypothyroidism. Methods The total of 40 subclinical hypothyroidism patients and 40 hypothyroidism cases was enrolled.The clinical hypothyroidism patients were treated with L￣T4 as the conventional treatment, and comprehensive CDDP plus levothyroxine (L￣T4 ) as treated groups (CDDP group) for 6 months. The therapeutic effect was evaluated by combining with data of thyroid function, blood lipid profile and ultrasound.The 40 healthy subjects were chosen as normal control group. Results Compared with normal control group, the levels of TC and LDL￣C were higher (P<0.05) in subclinical hypothyroidism group, which were more obvious in the clinical hypothyroidism group (P<0.01), CIMT increased markedly (P<0.05), the left ventricular systolic functions (ejection fraction) and diastolic functions (mitral flow velocity E and A wave ratio) were markedly decreased (P<0.05) in the clinical hypothyroidism group.Upon treatment, the blood￣lipids were improved (P<0.05), CIMT were reduced (P<0.05), the left ventricular functions were restored to near normal with the attainment of euthyroidism in both groups of clinical hypothyroidism;the reduction of CIMT and the improvement of the left ventricular functions were faster in CDDP group than that in the conventional treatment group (P<0.05). Conclusion Disturbance of blood lipid in hypothyroidism patients, CIMT growth and impaired left ventricular function objectively indicate the existence of cardiac and cerebral vascular risk, while CDDP helps improving lipid metabolism, reversing CIMT and cardiac function, reducing cardiovascular risk, blocking or delaying cardiovascular event chains.

Objective To investigate the role of c-Jun N-terminal kinase (JNK) signaling pathway in hyperoxia-induced expression of connective tissue growth factor (CTGF) in A549 cells.Methods The cultured A549 cells were seeded in 6-well culture plates at a density of 1 × 105 cells/ml (0.5 ml/well,24 wells in total) and were randomly divided into 4 groups (n =6 each) using a random number table:control group (group C);95％ oxygen group (group 95％ O2);room air plus SP600125 (JNK inhibitor) group (group C+SP);95％ oxygen plus SP600125 group (group 95％ O2+SP).SP600125 5 μmol/L was added to each well in C+SP and 95％ O2+SP groups.The A549 cells were incubated for 48 h in an incubator filled with room air (C and C+SP groups) or 95％ oxygen (95％ O2 and 95％ O2+SP groups).The expression of phosphorylated JNK (p-JNK) and CTGF mRNA was determined using Western blot and realtime reverse transcriptase polymerase chain reaction,respectively.Results Compared with group C,no significant change was found in the expression of p-JNK and CTGF mRNA in group C+SP (P＞0.05),and the expression of p-JNK and CTGF mRNA was significantly up-regulated in group 95％ O2 (P＜ 0.05).Compared with group 95％ O2,the expression of p-JNK and CTGF mRNA was significantly down-regulated in group 95％ O2+SP (P＜0.05).Conclusion JNK signaling pathway activation is involved in up-regulation of hyperoxia-induced CTGF mRNA expression in A549 cells.

It is important to analyze the epidermal growth factor receptor ( EGFR) mutation before makingstrategyonnon-small cell lung cancer ( NSCLC) patients scheduled to EGFR tyrosine kinase inhibitor ( TKI) therapy .Digital PCR is a new generation of molecular diagnostic technique that provides ultra-highersensitive, specific and absolute nucleic acid quantification based on its unique principle.The application of digital PCR indetecting circulate tumor DNA can be the truly tumorliquid biopsy, helps to acquire the accurate EGFR mutation status from peripheral blood and screen out the most appropriate patients for TKI therapy.This breakthrough technology will also contribute to tumor surveillance and drug resistance monitoring.