1.Bone metabolism in postmenopausal women and effect of calcium intake on their fracture risk
Chinese Journal of Clinical Nutrition 2011;19(4):263-268
The rate of bone turnover in postmenopausal women accelerates and the newly formed osteoid is poorly mineralized, resulting in the loss of bone mineral content. Meanwhile, the requirement for calcium increases as more bone matrix needs to be mineralized. On the other hand, the reduction of serum estrogen level impairs the absorption of calcium in intestinal tract and the reabsorption in kidney, resulting in the decreased absorption and increased excretion of calcium. Therefore, sufficient calcium intake is critical for maintaining the bone structure in postmenopausal women. The reference intake of calcium differs greatly among different countries. In 2000, China established the adequate intake of calcium for Chinese women aged 50 years and older as 1000 mg/d. Diets provide the optimal source of calcium to prevent osteoporosis. Although calcium supplements have been demonstrated to be beneficial for the bone mineral density in postmenopausal women, its impact on fracture risk and cardiovascular diseases remains controversial. Available evidences suggest that calcium supplements combined with vitamin D are unlikely to increase the risk of cardiovascular diseases.
2.Therapeutic effect of urapidil and nitroglycerin in elderly female non-valvular heart failure patients
Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2014;(10):1032-1034
Objective To assess whether urapidil (anα1 receptor blocker)is more effective than ni-troglycerin in treatment of non-valvular heart failure accompanying hypertension and diabetes mellitus (DM ) in elderly female patients .Methods Fourty-six elderly female patients with non-valvular heart failure accompanying hypertension and DM were randomly divided into urapidil treatment group (n= 24) and nitroglycerin treatment group (n= 22) .Patients in urapidil treat-ment group were treated with urapidil (50 -300 μg/min) and those in nitroglycerin treatment group were treated with nitroglycerin (5 -20 μg/min) for 48 -140 h according to their blood pressure (BP) and cardiac function .Their BP ,HR ,and metabolic activity were observed before and on days 1 ,2 ,3 and 7 after treatment .Results The effect of urapidil was significantly lower than that of nitroglycerin on SBP on day 7 after treatment (P<0 .05) .The serum NT-proBNP level was significantly lower in nitroglycerin treatment group than in control group (P<0 .01) . Conclusion The effect of urapidil is better than that of nitroglycerin on reducing and stabilizing SBP ,attenuating cardiac afterload ,and improving cardiac function in elderly female patients .Ura-pidil can thus be used as one of the first choiced drugs in treatment of elderly female patients with non-valvular heart failure accompanying hypertension and DM .
3.Application of personal digital assistant in rehabilitation assessment
Chinese Journal of Tissue Engineering Research 2007;0(30):-
With the rapid development of information technology at present, application of personal digital assistant (PDA) is becoming more and more popular. It not only can be seen everywhere in daily life, but also infiltrates into the insurance, medicine, finance, public security, aviation, and so on. Along with the construction of the digital hospital and introduction of software, such as "Military I" project, picture archiving and communication systems (PACS), Hospital information System (HIS), as well as the popularity of management software of medical equipments, the hospital puts forward higher requirements for medical work information management. PDA was used for rehabilitation assessment in this hospital from March 2007 to March 2009, which had a good result. Application of PDA in rehabilitation assessment greatly optimized workflow, which is the core objective of rehabilitation medicine. PDA is the necessary way for rehabilitation assessment to the "digital rehabilitation ".
4.Relationship between Injury Time and Expressions of EPO and Its Receptors in Rats Brain after Cerebral Injury
Journal of Forensic Medicine 2016;32(2):90-93
Objective To explore the relationship betw een injury age and expressions of erythropoietin (EPO ) and its receptor EPO R in the brain tissue of rats after cerebral injury. Methods Seventy-tw o rats w ere random ly divided into control group (36 rats) and cerebral injury group (36 rats). The rats w ere sac-rificed at 1, 2, 4, 8, 12, 24 h after cerebral injury (6 rats at each tim e point) and the brain tissues w ere extracted. The expressions of m RNA and protein of EPO and EPO R at different tim e points w ere de-tected by real-tim e fluorescent quantitative PC R and W estern bloting. Results The expressions of EPO and EPO R increased w ithin 24 h after injury. The expressions of m RNA and protein of EPO w ere relat-ed to the injury age, and the correlations w ere 0.875, 0.911, respectively (P<0.05). The expressions of m RNA and protein of EPO R w ere related to the injury age, and the correlation coefficients w ere 0.936, 0.905, respectively (P<0.05). Conclusion The expressions of EPO and EPO R increase gradually in the early stage of the rat’s cerebral injury, w hich are associated w ith the injury age and could be a useful value for estim ating injury age.
5.Influencing factors and interpretation of the clinical laboratory assay result of acute kidney injury
Chinese Journal of Laboratory Medicine 2016;39(12):879-884
[Abstrct] More and more laboratory indicators including serum creatinine , serum cystatin C , urinary microalbumin, N-acetyl-beta-D-Glucosaminidase (NAG), kidney injury molecule 1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18) and L type fatty acid binding protein (L-FABP) are used to diagnose and monitor acute kidney injury (AKI).However, the clinical applicability and limitations of these indicators , as well as the detection effect factors and biological variation on the diagnosis and monitoring of AKI are very important , especially how to combine the detection effect factors and biological variation to interpret test result is attached great importance by the laboratory personnel .
6.Progress in embolic stroke of undetermined source
Chinese Journal of General Practitioners 2016;15(3):225-227
Embolic stroke of undetermined source ( ESUS ) refers to non-lacunar brain infarcts without definite proximal arterialstenosis or major cardioembolic sources.Paroxysmal atrial fibrillation may be the most important cause of ESUS, thus anticoagulation may be more effective than antiplatelet therapy for secondary stroke prevention to this group of patients.This paper reviews the latest progress on the definition, epidemiology, diagnostic approach, relation to atrial fibrillation and management of ESUS.
8.Dural arteriovenous fistulas misdiagnosed as 1 case of thoracic stenosis
Chinese Journal of Primary Medicine and Pharmacy 2016;23(11):1746-1747,后插4
@@
9.Advance of research on ultrasound combined with microbubble contrast agent used in treatment of tumors
Journal of Medical Postgraduates 2003;0(11):-
In recent years,the effects of ultrasound combined with microbubble contrast agent in treatment of tumors has been become a new research hot point,which may have great potential in tumor treatment.Low-power ultrasound radiating microbubble embolization angiogenesis therapeutics has been widely used in tumor treatment.Among them the following foundation research aspects can make great breakthrough,such as : target drug delivery,target gene therapy,increasing high-intensity focused ultrosound therapy efficiency etc.
10.Research advances in NLRP3 inflammasome
Basic & Clinical Medicine 2015;(1):117-121
Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress -asso-ciated endogenous molecules and play an important role in innate immune system .Inflammasomes cause inflamma-tion response by inducing maturation of inflammatory cytokines interleukin ( IL)-1βand IL-18 through activation of caspase-1 ,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome , is-chemia-reperfusion injury and atherosclerosis .