OBJECTIVE:To evaluate the perioperative utilization of antibacterial drugs in patients undergoing modified radical mastectomy. METHODS: In this retrospective study, the perioperative utilization of antibacterial drugs in patients who underwent modified radical mastectomy during 2006 and 2006 were analyzed statistically. RESULTS: 100% of the patients received antibacterial drugs preventively. The problems involved in the preventive use of antibacterials manifested as medication without indications, irrational application of broad-spectrum antibacterials, frequent change of drugs, blind drug combination, inappropriate time of initial administration and prolonged drug use etc. CONCLUSION: The perioperative use of antibacterial drugs in patients undergoing modified radical mastectomy in our hospital is far from rational. The Clinicians' medication behavior should be standardized and supervision on rational drug use should be strengthened.

OBJECTIVE: To discuss the clinical characteristics and the patterns of allergic reaction(ADR) caused by aminoglycosides.METHODS: 98 ADR cases induced by aminoglycosides were retrieved from domestic journals reported from Jan.1990 to June 2007 for a statistical analysis.RESULTS: The ADR of aminoglycosides was closely related to route of administration,unreasonable application,allergic history,etc.CONCLUSION: The ADR of aminoglycosides and rational use of aminoglycosides should be strengthened further in the clinical practice.

Objective To study the CT and MRI findings of ganglioneuroma and compare with pathology . Methods Clinical data of 12 patients with ganglioneuroma confirmed by surgical pathology were retrospectively ana -lyzed.All patients underwent CT and MRI , and the results were compared with pathological results .Results The average size of the lesion was (4.7 ±1.2)cm,CT scan was uneven or uniform density.In MRI plain scan,T1WI showed heterogeneous low signal ,T2 WI showed uneven contour signal ,the middle part of the strip of low signal .12 cases received enhanced MRI scan ,there were four cases of non-enhanced,mild enhancement in 3 cases,uniformity progres-sive strength enhanced with two cases ,uneven progressive enhancement in 3 cases,there was 1 patient with edge of the annular reinforcing ,in accordance with CT scan results .Conclusion When CT and MRI used as the detection means of ganglioneuroma ,its performance has a certain characteristic ,and that reflects in large part the tumor shape ,size and tis-sue composition .And pathological tumor is rich in a lot of mucus matrix has a certain relationship .

Objective To investigate the prevention effect of Ezetimibe with loaded dose on hematologic parameters and re-infarction in patients undergoing PCI.Methods 240 cases of patients with non ST segment elevation myocardial infarction performed PCI from October 2012 to October 2014 were selected and randomly divided into two groups,the control group received conventional dose Ezetimibe 10 mg every time,qd,the study group received loading dose ezetimibe 20 mg every time, qd, both two groups treatment 30 days.The inflammatory factors, myocardial injury and vascular endothelial function were compared before, 24 h and 30 d after the operation, and patients were followed up for two years,record adverse reactions. Results Compared with before treatment,levels of serum inflammatory factor,myocardial injury and vascular endothelial function index in different time points had differences by single factor analysis of variance(P<0.05),and compared with the control group, levels of serum hs-CRP,TNF-α,IFN-γand IL-6 in the study group were lower, levels of serum CK-MB,cTnI and BNP were lower,the contents of ET in serum were lower,and the contents of NO were higher(P<0.05).The improvement degree in the study group of myocardial microcirculation perfusion after treatment was higher(P<0.05).No case shedding phenomenon occurred during the two year follow-up, and there was no statistical significance in the incidence of cardiovascular events between two groups.Conclusion Loading dose of ezetimibe can protect myocardium,and it can inhibit the inflammatory reaction and vascular endothelial injury caused by operation,it also can improve myocardial microcirculation.

China ; epidemiology ; Diagnostic Techniques and Procedures ; Epidemiologic Studies ; Hematologic Diseases ; diagnosis ; epidemiology ; Humans ; Incidence ; Meta-Analysis as Topic ; Multicenter Studies as Topic ; Prevalence ; Randomized Controlled Trials as Topic

Congenital anorectal malformation(CAM) is one of the most common colorectal diseases in children. Anoplasty has been the only treatment. Because of the fact that anorectal malformation is constantly complicated with congenital defect in the nerve and musculature, postoperative difficulty in defecation is common. Poor long-term quality of life of these affected children is a burden to the children, family, and society. With the advance of modern medicine, emphasizing the functional recovery after anatomical reconstruction of anorectum and conduction of individualized biofeedback training program to improve the defecatory function and long-term quality of life are the new treatment concepts and important progress. Novel methods for the prevention and treatment of CAM are still under exploration.
Anorectal Malformations ; Anus, Imperforate ; surgery ; Child ; China ; Digestive System Surgical Procedures ; Fecal Incontinence ; surgery ; Humans

Encouraging voluntary donation of citizens' organ is the best institutional solution for the severe shortage of organ transplantation.The policy incentives should allow donors to rescind their donation of their organ anytime before the organ is removed from their body.As long as the donor does not commit subjective offence,he/she shall be released from any legal responsibilities.This arrangement is highly significant legally and practically.

Objective To explore the relationship betw een injury age and expressions of erythropoietin (EPO ) and its receptor EPO R in the brain tissue of rats after cerebral injury. Methods Seventy-tw o rats w ere random ly divided into control group (36 rats) and cerebral injury group (36 rats). The rats w ere sac-rificed at 1, 2, 4, 8, 12, 24 h after cerebral injury (6 rats at each tim e point) and the brain tissues w ere extracted. The expressions of m RNA and protein of EPO and EPO R at different tim e points w ere de-tected by real-tim e fluorescent quantitative PC R and W estern bloting. Results The expressions of EPO and EPO R increased w ithin 24 h after injury. The expressions of m RNA and protein of EPO w ere relat-ed to the injury age, and the correlations w ere 0.875, 0.911, respectively (P<0.05). The expressions of m RNA and protein of EPO R w ere related to the injury age, and the correlation coefficients w ere 0.936, 0.905, respectively (P<0.05). Conclusion The expressions of EPO and EPO R increase gradually in the early stage of the rat’s cerebral injury, w hich are associated w ith the injury age and could be a useful value for estim ating injury age.

AIM: To investigate the infection of huma n embryo fibroblasts (HF) with CMV as well as the effect of CMV on ?-actin and mi crofilaments. METHODS: RT-PCR assay was used to detect the mRNA expression of CMV immediate early (IE) gene, ?-actin and GAPDH genes in HF cells infected wit h CMV. The morphological changes and microfilaments in infected cells were obser ved with transmission electron microscopy. RESULTS: The morphology of HF cells infected with CMV changed si gnificantly from fusiform shape to round shape. The mRNA expression of CMV immed iate early gene was detected. The increase in mRNA level of IE gene was parallel with the infected titer of CMV. However, t he expression level of ?-actin mRNA in HF cells infected with CMV was decreased compared with the uninfected cells, while the expression of GAPDH mRNA did not change. CMV particles were observed in the cells by electron microscope. Microfi laments were found ruptured and shortened after the infection of CMV. CONCLUSIONS: CMV was able to infect human embryo fibroblasts and replicated in the cells. Also the CMV infection affected the expressi on of ?-actin mRNA and the microfilaments.

Objective To study the results of blood coagulation test,including PT,APTT,FG and TT of pregnant women in different stage,and to discuss its clinical significance.Methods Blood coagulation monitor(STA-GO-ArT4,French)was used in this study.The experiment samples were divided into four grroups:group intermediate stage gestation(30 persons),group advanced stage gestation(26 persons),group in labor(30 persons)and group normal of none-gestation(37 persons).The prothrombin time(PT),activated partiat thromboplastin time(APTT).fibrinogen(FG)and thrombin time(TT)of these persons were detected.At last,the data of the test was analysised.Results The PT,FG and TT of the group advanced stage gestation and group in labor were higher compared with the group normal of none-gestation(P＜0.05).Conclusion The blood coagulation function of pregnant women in different stage is different from the none-pregnant women,and it is important to know the PT,APTT,FG and TT promptly.