Objective To study the clinical effect of serum calcitonin in the treatment of pediatric respiratory tract infections.Methods A retrospective analysis of our hospital in the patient's medical records from April 2015 to April 2016 were 80 cases of pediatric respiratory tract infection, were randomly divided into control group and observation group, 40 cases of respiratory tract infection were treated with standard antibiotic therapy in the control group, the observation group was treated with antibiotics in the treatment of serum calcitonin under the guidance of the comparative analysis of two groups of children with clinical efficacy, clinical symptoms disappear time, antibiotic use and hospital economy.Results The effective rate of control group was 70%, and the observation group was 90%.The clinical efficiency of the observation group was relatively higher than control group ( P <0.05).Compared with the control group, the clinical symptoms of the patients in the observation group were significantly lower than that of the control group(P<0.05).Patients in the observation group used antibiotics was 16 cases(40%), the antibiotic use rate was, 32 cases(80%) in the control group, the average usage time of antibiotics and the average cost of observation group was significantly lower than control group(P<0.05)..The time of hospitalization and the hospitalization expenses of,observation group were lower than control group(P<0.05).Conclusion The treatment of pediatric respiratory infection in serum calcitonin can help improve the clinical efficacy, reduce the use of antibiotics in children with high economic.

Objective To compare the clinical outcome of procedure for prolapse and hemorrhoids (PPH) and PPH + selective Milligan-Morgan hemorrhoidectomy(MMH) in surgical treatment of Ⅲ ～ Ⅳ stage hemorrhoids and research the best surgical procedures.Methods Retrospective analysis was made on the clinical data of 125 cases with Ⅲ ～ Ⅳ stage mixed hemorrhoids,they were non-randomized-controlled divided into PPH group (group 1) and PPH + selective MMH group(group 2),comparing the data of recurrence,complication and symptoms relief including anal prolapse,bleeding,anus fall feeling,wet anus and pruritus ani.Results While observing 3 years after operation,group 1 and group 2 both relieved symptoms of anal prolapse,bleeding,anus fall feeling,wet anus and pruritus ani.The relief rate of these symptoms in the two group were all high than 92%.There was one cases relapsed in the group 2 (the recurrence rate of 2%) was better than the group 1 (the recurrence rate of 13%) which were 8 case,there was a significant statistical significance (x2 =4.629,P ＜ 0.05) in the recurrence and clinical outcome.Conclusion Radical choose of PPH and selective MMH to treat Ⅲ ～ Ⅳ stage mixed hemorrhoids patients,which could relieve postoperative symptoms and acquire better long-term clinic outcomes.

Objective To investigate the effect of focal cerebral ischemic preconditioning (IPC) on brain edema and the expression of nuclear factor-?B( NF-?B) and its target gene MMP-9. Methods Forty-five SD rats were divided into 3 groups in which control group received sham surgery only, and the other two groups received 2 hours of middle cerebral artery occlusion (MCAO) followed by 22 hours of reperfusion with or without 10 minutes of IPC 3 days before. Brain water content, expression of NF-?B and MMP-9 mRNA were evaluated in each group by wet-dry weight method, immunohistochemistry staining and RT-PCR. Results Compared with the SS group, there was a lower NF-?B immunoreactivity and MMP-9 mRNA level (16 098.2?1 265.3 vs 23 565.8?1 978.4,50.7% vs 84.1%, P

Studies have found that depression is closely related to the hyperactivity of the hypothalamo–pituitary–adrenal (HPA) axis, which is manifested in increases in HPA axis-related hormones CRH, ACTH and CORT contents. Traditional Chinese medical acupuncture can down-regulate HPA axis levels to produce a marked antidepressant effect. However, at present there is no HPA axis mechanism analysis of the antidepressant effect of acupuncture. From two aspects: the relationship between depression and HPA axis, and clinical and animal mechanism studies of the antidepressant effect of acupuncture by regulating the HPA axis, an analysis has been made to provide a more powerful scientific basis and the idea of further in-depth study for clinical acupuncture treatment of depression.

Decompression, Surgical ; Gout ; Humans ; Lumbar Vertebrae ; Spinal Stenosis

The precise relationship between the degree of pain and the degree of inflammation in the individual remains debated. A quantitative analysis simultaneously applied to the immediate and prolonged painful consequences of inflammation has not yet been done. Thus, the correlations between edema, nociception and hypersensitivity following an inflammatory insult were assessed in rodents. To better understand the therapeutic value of modifying specific aspects of inflammation, the effects of an anti-inflammatory drug were compared to the results. Inbred strains of mice and outbred rats received an intraplantar injection of honeybee venom and the between-group and within-group correlations were calculated for spontaneous nociceptive measures, thermal and mechanical hypersensitivity, and edema and temperature. The effect of indomethacin on the pain and inflammation measures was examined. Edema correlated with spontaneous flinching, licking and lifting of the injected paw (P< or =0.003), and not with thermal or mechanical hypersensitivity. Indomethacin affected edema and spontaneous nociception dose-dependently, and affected hypersensitivity only at the highest dose tested (P< 0.05). These results suggest that edema may contribute only to immediate spontaneous nociceptive responses to an inflammatory insult, and not to the more clinically relevant prolonged hypersensitivity. This analysis represents a method for determining which inflammatory processes are the most promising therapeutic targets against the multiple painful consequences of inflammation.
Animals ; Anti-Inflammatory Agents, Non-Steroidal ; pharmacology ; Bee Venoms ; Edema ; chemically induced ; complications ; Indomethacin ; pharmacology ; Inflammation ; chemically induced ; complications ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Nociceptors ; physiology ; Pain ; etiology ; physiopathology ; Pain Measurement ; Rats ; Rats, Sprague-Dawley

In the original publication of the article, the representative EEG of female rat pups with FS in Figure 1 C and D was incorrectly intercepted from that of male rat pups. This correction does not affect the conclusions of the paper. Figure 1 has been corrected on the online PDF version and displayed below.