MicroRNA (miRNAs) are endogenous,small and noncoding regulatory RNAs,which widely exist in eukaryotes.MiRNAs regulate the expression of target gene by translating inhibition or mRNA destabilization.MiRNAs have been recognized as a major regulatory fashion of post-transcriptional gene expression and play important roles in many cellular biological processes,including cellular proliferation,diffcrentiation,cell death.Alteration of expression and/or dysregulation of miRNAs are related to a wide variety of severe fundus diseases,such as diabetic retinopathy,age-related macular degeneration and retinoblastoma.This review aimed to provide a summary of the recent progress in the effect of miRNAs on fundus diseases.

Pain is one of important topics in Bioethics.Pain,which looks like a simple physical symptom,involves the crucial ethical value.In Western bioethics,pain has been discussed for some decades.However,pain still hasn't been emphasized as an important topic in Chinese Bioethics world.Therefore,from bioethical perspectives,this article attempts to study pain under four subtitles: the notion of pain;some bioethical debates about pain;narrative of pain and illness,and pain: a way to go further for Bioethics studies.

In modern world,bioethics has become an international social movement since its inception during the mid-twentieth century.In the practices of clinical bioethics,methodology is the most crucial issue concerned by western scholars.Briefly,the article introduces and analyzes the empirical approach in contemporary European world,as well as explains the interaction between bioethics and naturalism.Based on current development of mainstream ethics,the article also tries to answer the question about "is and ought" in the background of clinical practice.The research aims at providing the ideas and experiences for the development of Chinese clinical bioethics.

The actuality of natural medicines in China,Europe,America,and Korea were explained, and analyzing existing problems of research and development of the natural medicines in China combing development trend of natural medicines,research trend,future direction,thought and methods for research of natural medicines were put forward in the paper.

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

Acrylonitrile ; toxicity ; Animals ; Male ; Mice ; Mice, Inbred Strains ; Testis ; drug effects ; pathology

Adaptor Proteins, Signal Transducing ; genetics ; Bone Marrow Diseases ; genetics ; pathology ; DNA Mutational Analysis ; DNA-Binding Proteins ; genetics ; Exocrine Pancreatic Insufficiency ; genetics ; pathology ; Glucose-6-Phosphatase ; genetics ; Humans ; Leukocyte Elastase ; genetics ; Lipomatosis ; genetics ; pathology ; Mutation ; Neutropenia ; congenital ; genetics ; Proteins ; genetics ; Transcription Factors ; genetics

Objective:To analyze the causes and countermeasures for the inefficiency of implementing the contract community health service policy.Methods:Based on the authority and regulation of organization,it innovatively used the French organization theory,build an analysis framework of organizational actors adapting to the general organization.On the above basis combined with the characteristics of contract health service,it constructed a new organizational structure of contract health service and analyzed the low efficiency of policy implementation from the three relations among the actors,the power and the rule.Results and Conclusion:It needed to focus on authority and rule to rationally division the authorities of actors,optimize the organizational structure,adjust the benefit relationship of actors;play the regulation role,implement the incentive and constraint mechanism to improve the execution efficiency of contract health service policy.

In this paper, 172 non-public hospitals have been investigated covering east, central and western regions with structured and semi-structured questionnaire and group interviews. We found that the health insurance policies were the most concerned policies by non-public hospitals, accounting for 26.5% of the total. We also found that non-public hospitals from different areas, levels profit nature have different policy expectations, for example Eastern regional institutions wanted to make a breakthrough of the planning policies, the central region wanted to change the health personnel policy, while the western region is considered to be limited by land policy. Tertiary hospitals were more concerned about research projects and land policy, and secondary hospitals were more concerned about access policy. There were 44.8% of the surveyed institutions considered that regulatory policywasmore stringent public hospitals and public hospitals, and there were no difference between profit and non-profit hospitals. According to the survey results, this paper puts forward suggestion that we should implement more targeted policies, purchasing more services from non-public hospitals and enhanced supervision. Considering the survey results research team puts forward sensitive advice as: provide preferential policies in according with different kinds of institutions reinforce purchasing service and enhance non-public hospitals supervision.