1.The relationship between C-reactive protein and metabolic syndrome in obese children
Chinese Journal of Primary Medicine and Pharmacy 2014;21(12):1804-1806
Objective To investigate the relationship of the C-reactive protein (CRP) and metabolic syndrome.Methods The serum level of CRP was determined in 48 cases of obese children and 36 cases of healthy individuals.All children were 10 years old.The differences between the two groups and whether CRP was associated with metabolic syndrome were analyzed.Results The obese children had significant higher serum insulin,TG,TC,CRP,BMI,SBP and HOMA-IR [for respectively (16.1 ± 3.7) mU/L,(1.38 ± 0.29) mmol/L,(4.79 ± 0.88) mmol/L,(1.83 ± 0.89) mg/L,(28.7 ± 5.3) kg/m2,(129.4-11.3) mmHg,(3.81 ± 0.92)] than those of the normal controls [for respectively(10.4 ±2.8) mU/L,(0.75 ±0.12) mmol/L,(4.12 ± 0.65) mmol/L,(0.78 ± 0.22) mg/L,(22.4 ± 3.9)kg/m2,(117.2 ±8.9) mnHg,(2.37 ±0.78)] (t =7.727,12.260,3.846,6.912,6.012,5.349,7.568,all P <0.05).The results of correlation analysis showed that CRP had a positive correlation with serum insulin,TG,BMI,SBP and HOMA-IR (r=0.693,0.293,0.525,0.212,0.195,all P<0.05),but not TC.Conclusion There are significant increases of serum CRP level in obese children,and the increased CRP was closely related with metabolic syndrome.
2.Clinical study of compound bFGF preparations on patients with recurrent aphthous ulcer
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(03):-
AIM: To observe the recent curative effect of basic fibroblast growth factor(bFGF) to patients with recurrent aphthous ulcer(RAU). METHODS: 60 patients with RAU were treated by locally spraying compound bFGF preparations composing of calculated quantity of bFGF, tinidazole and dicaine on the surface of ulcerations,?other?40?patients?were?treated?by?alternatively smearing Xi Leisan and Smecta on the surface of ulcerations as routine treatment group, tid, for 5 d. RESULTS: The improvement of three indexes including the size, the degree of ache and hyperemia of the ulcerations are greater in compound bFGF treatment group than those in routine treatment group (P
3.Neuroprotective therapy for glaucoma
Chinese Journal of Experimental Ophthalmology 2015;33(3):279-283
Glaucoma is the second leading cause of blindness worldwide.It is mainly caused by glaucomatous optic neuropathy characterized by retinal ganglion cells (RGCs) loss,which leads to visual field loss and blindness.There are many risk factors other than intraocular pressure (IOP) elevation are thought to be responsible for RGCs damage induced by glaucoma,such as neurotrophic factors deprivation,excitotoxicity,oxidative stress and enhanced microglia activity,and these factors are essential for glaucomatous optic neuropathy,especially in normal tension glaucoma (NTG).Up to date,the major attempt of glaucoma therapy is to protect optic nerve function by lowering IOP through surgery and drugs.However,the therapies can not arrest RGCs damage although effectively lowing IOP in a number of patients.Novel study is turning to find and develop some new approaches to solve neuroprotection problem targeting to the pathogenic factors of glaucomatous optic neuropathy out of IOP.This review paper mainly focused on the neuroprotective therapies that are developed in the past few years.
4.Study on relationship between growth hormone, leptin, thyroid hormone in cord blood and fetal growth
Chinese Journal of Primary Medicine and Pharmacy 2014;21(13):1969-1971
Objective To explore the role of growth hormone (GH),leptin (Lep),T3,T4,TSH in cord blood in intrauterine growth.Methods 120 healthy newborns (60 males,60 females) were enrolled in this study.The neonates were divided into AGA,LGA and SGA groups according to the relationship between birth weight and gestation.The head circumference,birth length,birth weight,body mass index,biparietal diameter,and placental weight,the levels of GH,Lep,T3,T4,TSH in the cord blood were measured.Results There were significantly statistical differ ences in growth indexs (all P < 0.05),the levels of GH and TSH were significantly increased [(21.52 ± 2.13) ng/L vs (15.64 ± 1.28) ng/L ; (8.6 ± 0.67) mIU/L vs (3.34 ± 0.29) mIU/L,t =3.042,4.367,all P < 0.05] and Lep,T3,T4 were significantly decreased in LGA group when compared with the AGA group [(7.53 ±0.81) g/L vs (9.55 ± 1.26) g/L; (1.25 ± 0.42) nmol/L vs (1.48 ± 0.37) nmol/L; (69.45 ± 10.07) nmol/L vs (76.68 ± 8.22) nmol/L; t =1.749,1.905,1.783,all P < 0.05],the level of Lep in LGA group was significantly higer than that in AGA group [(14.61 ±2.05) g/L vs (9.55 ±1.26) g/L,t =3.064,P <0.05].And GH,Lep,T3,T4 were positively correlated with head circumference,birth length,birth weight,body mass index,biparietal diameter,and placental weight (all P < 0.05).TSH was negatively correlated with growth indexs.Conclusion The levels of Lep,T3,T4,TSH in cord blood were associated with fetal growth and could be used as indicators of intrauterine growth.
5.Analysis of teaching difficulties in "metal materials and heat treatment technology" and solution strategies
Chinese Journal of Rehabilitation Theory and Practice 2011;17(5):498-499
“金属材料与热处理技术”是首都医科大学假肢矫形工程专业本科生必修的专业基础课程。金属的晶体结构与滑移系的概念以及铁碳合金相图是“金属材料与热处理技术”教学中比较复杂的知识点。本文对此进行探讨,并提出一些解决方法。
7.Spinal cord morphology research of nursing intervention on motor function repair after spinal cord injury in rats
Journal of Regional Anatomy and Operative Surgery 2015;(1):18-22
Objective To explore the morphology changes of spinal cord after nursing intervention on motor function repair spinal cord injuried rats. Methods 60 adult SD rats were randomly divided into normal control group, experimental control group, and experimental group ( n=20 for each group) . Each group were divided into four time phase points, that is 1 day, 7 days, 30 days and 60 days after spinal cord injury (n=5). The model of L4 plane with full transection of spinal cord were made in the rats in experimental control group and exper-imental group. Normal control group were of untreated normal rats, experimental control group were given routine nursing such as urination and defecation after spinal cord injury, and experimental group were given passive movement practices and muscle massage training twice a day (10 min each time) besides regular nursing. HE staining and immunohistochemistry method were applied to observe the morphology changes of spinal cord. Results In experimental control group and experimental group there was no significant changes in HE staning and NF-200 and GFAP immunohistchemistry staning in spinal cord section of rat at each time phase points, but compared to the normal control group, it was of significant difference. Conclusion There is no apparent change in morphology in injured spinal area after nursing intervention.
8.Effect of nursing intervention on motor function recovery after spinal cord injury in rats
Journal of Regional Anatomy and Operative Surgery 2014;(3):238-241
Objective To explore the effect of nursing intervention on degree of motor function recovery after spinal cord injury in rats. Methods 60 rats were randomly divided into three groups with 20 rats in each group. Group A was the control group,group B was the rou-tine nursing group,and group C was the nursing intervention group which was given nursing intervention such as muscle pressure,joint passive movement,and skin care. The ethology was evaluated by BBB score and inclined-plane score at different time points after spinal cord injury. Myoelectricity and wet weight of gastrocnemius muscle were observed at different time points after spinal cord injury through multi-channel physiological signal acquisition system and electronic weighing scales. Results BBB score and inclined-plane score were basically the same. Compared with group B,hind limb function of group C was significantly improved,but it was obviously lower than the control group. Amplitude of gastrocnemius myoelectrical fibrillation in group C was higher than that in group B and gastrocnemius muscle wet weight decrease in group C was lower than that in group B. Conclusion Nursing intervention can delay the speed of gastrocnemius muscle atrophy,improve motor function,and promote the recovery of partial function after the spinal cord injury in rats.
9.Application of resonance frequency analysis in measuring the stability of implants
International Journal of Biomedical Engineering 2006;0(02):-
Resonance frequency analysis(RFA) has been successfully applied to measure the stability of implants, and proved to an objective method. Domestic and international scholars in the field of organ implantation have paid great attention on RFA in recent years. The present paper systematically introduces principles and applications of RFA in buccal medicine. The advantages and insufficiencies of RFA are discussed too.
10.Research progress in angiogenesis mechanism and management of pterygium
Chinese Journal of Experimental Ophthalmology 2012;30(2):172-175
Pterygium is a common ocular surface disorder,which causes lowing of vision even blindness once invading into cornea.The pathogenesis of pterygium is still incompletely clear.Recently studies showed that the interaction of a lot of factors lead to the proliferation of pterygium,and angiogenesis may play an important role in the formation and progression of pterygium.The therapies of pterygium focus on surgical resection with autologous conjunctival transplantation,amniontransplantation or transplantation of limbal stem cells,but a high recurrence rate of pterygium is worth studying.The angiogenesis of pterygium is a key problem.This article summarized the research outcomes in regulation and treatment about angionesis in pterygium.