OBJECTIVE:To provide reference for the evolvement of the current drug marketing license system in China. METHODS: The registry classification, the drug registration procedure and the combination of marketing license and production license both at home and abroad were analyzed comparatively. In addition, the necessity and feasibility of the drug marketing license system in China were analyzed. RESULTS & CONCLUSIONS: The current drug marketing license system that centered on license No. goes against the investigation of legal ability, drug administration mode, medicine technology transfer system and original equipment manufacture thus remains be reformed. There is still difficulty for the enforcement of drug marketing licensor system, yet it should be carried out step by step until its establishment.

OBJECTIVE To investigate the clinical characteristics and the present condition of infective diabetic foot. METHODS A total of 100 cases with infective diabetic foot were classified into the wet gangrene and composite gangrene, and treated by the systemic and local modality in combination. RESULTS The cure rate of the wet gangrene and composite gangrene was 29.5% and 18.2%, respectively and the effective rate was 83.3% and 68.2%, respectively. CONCLUSIONS The combined therapy is effective for the treatment of diabetic foot.

Objective To investigate the clinical characteristics and treatment of senile patients with lumbar disc protrusion . Methods The clinical data of 56 cases of senile lumbar disc protrusion from 1990 to 2000 were reviewed retrospectively. Results 48 patients had been followed for 6 months to 7.5 years with average 4 years. Excellent and good results were 41 cases (85.4%).Conclusions There was atypical symptom in the senile patients with lumbar disc protrusion. CT was an important methods for diagnosis. The after concomitant diseases were controlled, resecting half vertebral lamina and enlarging fenestration were performed. The therapeutic results were satisfactory.

The high-intensity interval training often consisted of groups of interval high-intensity exercise of exhaustion or above 90%maximal oxygen consumption, which can be applied to improve aerobic capacity. Adaption of skeletal muscles might be resulted from high-intensity interval training, including recruitment, glucose metabolism and activity of mitochondrial oxidase, etc., and improve maxi-mum oxygen uptake. It has been used for physical fitness, such as weight reduction, rehabilitation of heart diseases and diabetes mellitus, etc.

Rheumatoid arthritis ( RA) was a common autoimmune disease characterized with main clinical manifestations of chronic inflammation in joints.Anti-carbamylated proteins(anti-CarP)antibody, as a promising bio-marker, played a crucial role in the diagnosis of RA patients and the screening of pre-RA patients .In this article , recent progress on the study of anti-CarP antibody and RA related diseases has been reviewed , which was expected to provide new references for the diagnosis and treatment of related clinical diseases .

Objective To investigate the clinical efficacy of mind- and qi-regulating acupuncture in treating postoperative gastroplegia.Methods Thirty-six patients with postoperative gastroplegia were randomly allocated to treatment and control groups, 18 cases each. The control group received conventional acupuncture and the treatment group, acupuncture at points for regulating mind and qi (Baihui, Sishencong and Yindang) in addition. Pre- and post-treatment Hamilton Depression Rating Scale (HAMD) scores and gastric drainage volumes, and the number of treatments and the recovery rate were recorded in the patients. Comparisons of them were made between the two groups.Results There was a statistically significant pre-/post-treatment difference in the HAMD score in the two groups (P<0.01). There was a statistically significant post-treatment difference in the HAMD score between the treatment and control groups (P<0.05). There was a statistically significant pre-/post-treatment difference in gastric drainage volume in the two groups (P<0.01). There were statistically significant differences in the number of treatments and the recovery and marked efficacy rate between the treatment and control groups (P<0.05).Conclusions Mind- and qi-regulating acupuncture helps recovery and can also reduce the number of treatments in gastroplegia patients.

Drugs, Chinese Herbal ; therapeutic use ; Histiocytic Necrotizing Lymphadenitis ; drug therapy ; Humans

Animals ; Catalysis ; Cell Adhesion ; drug effects ; radiation effects ; Humans ; Hydrophobic and Hydrophilic Interactions ; Osseointegration ; drug effects ; radiation effects ; Osteoblasts ; cytology ; drug effects ; radiation effects ; Osteogenesis ; drug effects ; radiation effects ; Photochemical Processes ; Surface Properties ; radiation effects ; Time Factors ; Titanium ; chemistry ; pharmacology ; radiation effects ; Ultraviolet Rays

Sarcopenia is a series of syndromes featured by the steady and involuntary loss of skeletal muscle mass and function with aging.It can lower the quality of life and increase the risk of disability and mortality.Deficiency in some nutrients such as amino acids and proteins and accordingly the decreased in the synthesis of muscle protein and changes in muscle tissues may contribute to the development of sarcopenia.Therefore,nutritional interventions may play a role in the prevention and treatment of sarcopenia.

Objective To Study the effect of long-term triptolide use on the content of the normal rat plasma ACTH.Methods 20 male SD rats were divided into 2 groups randomly,and gavaged for 7 weeks.The control group was 10 with 2%propylene glycol 2ml/kg,bid;the group of Triptolide was 10 with 2% the mixture of propylene glycol and Triptolide 20?g/kg,bid.We used radioimmunoassay to detecet the content of ACTH in rat's plasma and immunocytochemistry to detecet the expression of ACTH in pituitary. Results The content of ACTH in the group of the Triptolide had significant difference as compared with control group.The expression of ACTH in the group of the Triptolide was higher than that of control group. Conclusion These results suggested that one of the possible mechanism of the Triptolide in the HPAA might be exciting pituitary ACTH neurons,thus causing the content of ACTH increasing.