Objective The purpose of this study was to examine the effects of exercise training on cardiac function and automatic nervous activity in patients with coronary artery disease(CAD) following PTCA or intracoronary stent implantation. Methods For this study, 37 CAD patients (28 men and 9 women; aged 56.23 ?11.16 years) participated in a supervised 8-week training program with 35 healthy controls(27 men and 8 women; aged 55.72 ?10.34 years). Cardiac function was assessed with indexes obtained during exercise testing using the standard Bruce protocol (submaximal gradural treadmill exercise) before and after 8 weeks training. Meanwhile, heart rate variability (HRV) was used to value the automatic nervous activity. Results After 8 weeks, the margin between maximal HR and resting HR (△HR=HR max-HR resting) was significantly broader (P

The discipline of nutrition has been developing quickly in the past 30 years in China,and a number of scientific progress has been achieved.Some new discoveries have been unveiled in terms of treatment and prevention of liver carcinoma,colon cancer,and breast cancer by certain nutrients.Besides,the application of nutrition in the prevention and treatlnents of metabolic diseases such as obesity.diabetes mellitus and congenital malfcIrmation has been studied.Furthermore,academic achievements in the treatment of tumor and metabolic diseases by integrating nutritional therapies has also been made.The establishment of relevant organizations and institutes as well as the prosperous performance of nutrition education contribute to the development of discipline of nutrition in China.

Child Nutrition Sciences ; Health Knowledge, Attitudes, Practice ; Humans ; Physicians

It has been reported that the level of antioxidants is lower in obese patients compared with that in normal weight subjects. Important antioxidants, vitamin E and ?-carotene, are lowered in obese adults and children, which may cause lipid super oxidation and are associated with atherosclerosis, coronary heart disease and myocardial infarction. Copper and zinc are trace elements that compose parts of enzymes such as CuZn-superoxide dismutase (CuZn-SOD) which can scavenge free radicals. Plasma copper and zinc levels are lowered in obese individuals, which may lead to abnormality in glucose metabolism.

Objective To explore a simple, effective and stable method for the isolation and purification of Kupffer cells from rat liver, enabling further study on the structure and function of these cells in vitro. Methods After laparotomy, a catheter was inserted into the portal vein and secured with artery clamp. Then, the rat liver was perfused and digested with solution Ⅰ and solution Ⅱ containing 0.05% collagenase Ⅳ respectively. The cell suspension was centrifuged with isopycnic sedimentation in a two-step Percoll gradient to harvest Kupffer cells. The isolated Kupffer cells were purified by selective adherence after 30 min of cultivation, and identified by evaluation of phagocytosis of India ink and peroxidase staining with DAB through light and electron microscopy. Results It was verified that the viability of isolated Kupfffer cells was more than 90% through Trypan blue staining. Those Kupffer cells could attach to plastic quickly and phagocytose ink, and had the appearance of "fried eggs" in positive peroxidase staining with a purity of 95%. Under the light microscopy, the appearance of newly isolated Kupffer cells was round with uniform shape and size. After two days of culture, Kupffer cells appeared to distend with irregular or stellate shape. The typical features were observed in the transmission electron micrographs. There were numerous pseudopods and occasional cup-like indentations in the cell membrane of Kupffer cells. The cytoplasm contained numerous types of lysosomes and other phagocytotic vesicles. Conclusion The method for isolating and culturing Kupffer cells in this study is effective and stable, and the biological characters are preserved in the cultured cells.

Peripherally inserted central catheter(PICC) is now often used in pediatric patients.PICC is easily inserted,safe,and cost-effective.Although it has many benefits,physicians and nurses remain acutely aware of the problem involved with placement of PICC lines.This review is about the research progress of PICC line related problems.

Glutamine(Gln) is the most abundant free amino acid in the circulation. However, Gln depletion is obviously increased in critically ill patients. The liver plays a key role in glutamine metabolism since it can either generate or consume Gln. A number of studies have demonstrated that administration of Gln can protect from liver damage during sepsis or chemotherapy. The mechanism may be that glutamine can be more efficiently transported across cell membranes for glutathione synthesis. Supplement of Gln to PN has been proven to maintain intestinal integrity and reduce bacterial translocation. As a gluconeogenic amino acid, Gln can decrease the portal insulin/glucagon ratio and prevent hepatic steatosis through stimulating glucagon secretion.

L-Carnitine plays an essential role in the transfer of long chain fatty acids from the cytoplasm of a cell into the mitochondrion,where they undergo ?-oxidation.Carnitine deficiency is characterized by plasma and tissue carnitine concentrations below those required for the normal functions of the organism,including cardiomyopathy,myopathy,hypoketonemia,hypoglycemia,hyperammonemia.Studies show that supplement of carnitine could improve the clinical symptoms of some diseases.

Objective To observe the clinical efficacy of intradermal needle therapy in treating chronic pharyngitis.Method Sixty patients with chronic pharyngitis were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by intradermal needle therapy at Lieque (LU 7) and Zhaohai (KI 6), while the control group was by Compound Borax solution plus Cydiodine Buccal tablets. The symptoms were scored before and after treatment, and the clinical efficacies were compared.Result The total effective rate was 93.3% in the treatment group versus 80.0% in the control group, and the difference was statistically significant (P<0.05). The symptom scores were markedly changed after the treatment in both groups (P<0.01). The symptom score of the treatment group was significantly different from that of the control group (P<0.05). Conclusion Intradermal needle therapy is an effective method in treating chronic pharyngitis.

Overnutrition during the early postnatal life,a critical time window for growth and development,may induce metabolic syndrome later in life,including overweight/obesity and insulin resistance.The important target organs of insulin,such as liver,adipose tissue,skeletal muscle,and central nervous systems show insulin resistance.The involved mechanisms include abnormality of insulin signal pathway,increment of free fatty acid and some adipocytokines,oxidative stress,maladjustment of orexigenic and anorexigenic neuron,modifications of the hypothalamic-pituitary-adrenal glucocorticoid axis as well as epigenetic,etc.Hence,overnutrition should be avoided during the early postnatal life,so as to decrease the risk of developing long-term insulin resistance.