Objective To analysis clinical significance of joint detection of serum Cys C,Hcy and mAlb in HDCP patients. Methods Selected 92 cases of HDCP patients in Guangji hosipital of Hezhou from Jun 2011 to Jun 2014 as observation group.They were divided into three groups (43 patients of gestational hypertension as group A,32 patients with mild pre-eclampsia as group B,17 patients of severe preeclampsia as group C)and chose 50 cases of healthy maternal the same period in the hospital as control group.Enhanced turbidimetric method for the determination of serum Cys C,Hcy,immune scatter-ing method for urinary mAlb,the results were analyzed.Results Observation group with the level of serum Cys C,Hcy and urinary mAlb was rise with the damage degree aggravating,group C rise significantly (F =4.567,P <0.001).Observation group serum Cys C,Hcy and abnormal detection rate of urinary mAlb level was rise at the same time renal damage degree aggravating,group C rise significantly (χ2 = 12.842,P <0.001).Three joint detection indices abnormal detection rate was significantly higher than that of single detection (χ2 =5.869,P <0.001),the detection sensitivity of 95.70% has significant advantage (χ2 =15.992,P <0.001).Conclusion The joint detection of renal function of serum Cys C,Hcy and mAlb in HDCP patients was better than the single detection,which is helpful for the early detection of HDCP patients with renal damage,it’s worthy clinical promotion.