Objective:To analyze Bufei Huo Xue Tang combined with Western medicine for chronic obstructive pulmonary disease( COPD) and its effect on airway inflammation reduction and lung function improvement. Methods: 100 patients with stable COPD in our department from February 2013 to March 2015 were randomly divided into combination group and control group. The control group received conventional oxygen,salmeterol and fluticasone propionate inhalation powder(1 absorption /times,2 times /day) and expectorant treatment. Combination group were based on the addition of lungs Bufei Huo Xue Tang with a course of 12 weeks. The clinical efficacy and α1-AT and IL-8 levels in two groups of patients were compared. Results:The cough,sputum,difficulty breathing, wheezing,wheezing symptom score in the combined group after treatment was significantly lower than the control group ( P<0. 05 ) . FVC,FEV1 and FEV1 /FVC in the combined group after treatment was significantly lower than those in the control group(P<0. 05).α1-AT and NO in the combination group was significantly higher after treatment. IL-8 and TNF-α was significantly lower than the control group(P<0. 05). BODE scores in the combined group after treatment were significantly lower than the control group(P<0. 05). Conclusion:Bufei Huoxue soup combined with Western medicine for COPD can inhibit inflammation,improve clinical symptoms,lung function and quality of life.