Objective In order to explore the localization of NGB mRNA in adult rat brain. Methods In the present study,the localization of NGB mRNA in brain of the adult rat was examined by in situ hybridization histochemistry using digoxigenin labelled cRNA probes. Results Transcripts of NGB mRNA were showed to be widely distributed throughout the adult rat brain,including cerebral cortex,hippocampus,thalamus,hypothalamus,cerebellum and olfactory bulb.Conclusion\ Our result suggested that NGB gene might play an important role in the central nervous system,possibly related to the oxygen supply of the neuron.
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